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A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19

Completed · Phase 3 · NCT05815498

Conditions: COVID-19

At a glance

Research payments reported, 2025
$10.2M
U.S. investigators named
151
Sites paid
76
Planned or actual enrollment
13,553

About the trial

Sponsor
ModernaTX, Inc.
Tested
mRNA-1283.222 (biological), mRNA-1273.222 (biological), mRNA-1283.815 (biological), mRNA-1273.815 (biological)
Dates
Started 2023-03-28; completion 2025-04-12
Results posted
Yes

The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-1283.222 versus mRNA-1273.222 (Part 1) and mRNA-1283.815 versus mRNA-1273.815 (Part 2).

From ClinicalTrials.gov, last updated 2026-05-01. Full record, eligibility and contacts (opens in a new tab)

Industry funding

ModernaTX, Inc. reported $10.2M in research payments for this study in 2025 (2,422 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Delricht Research $1.6M
  • Velocity Clinical Research Inc $1.6M
  • Qcare Site Services Inc $545,755
  • Marvel Clinical Research 002 LLC $303,774
  • Dynamed Clinical Research LP $289,183
  • Precision Clinical Research LLC $277,390
  • Sundance Clinical Research LLC $276,173
  • Noble Clinical Research LLC $238,570
  • Pines Care Research Center LLC $232,727
  • Suncoast Research Associates LLC DBA Sra Trials $218,723
  • Tekton Research LLC $210,810
  • Sandhill Research LLC $208,006
  • Monroe Biomedical Research $205,403
  • Hillcrest Medical Research LLC $202,628
  • Chicago Clinical Research Institute Inc $200,235
  • Las Vegas Clinical Trials LLC $174,531
  • Global Health Research Center $172,492
  • Clinical Research Associates Inc $165,053
  • Headlands Horizons LLC $157,608
  • Alliance for Multispecialty Research LLC $149,668
  • Panamerican Clinical Research LLC $145,431
  • Spartanburg Medical Research LLC $143,492
  • Cognitive Clinical Trials LLC $127,864
  • Peninsula Headlands LLC $122,770
  • J Lewis Research Inc $116,993
  • Lynn Health Science Institute Inc $115,348
  • Chandler Clinical Trials LLC $103,943
  • Health Awareness LLC $103,474
  • Chemidox Advance Clinical Trials LLC $95,447
  • Clinical Site PArtners Inc $93,991
  • Johnson County Clintrials LLC $93,703
  • Del Sol Research Management LLC $86,477
  • Jacksonville Center for Clinical Research $83,383
  • Long Beach Clinical Trials Services Inc $80,762
  • Coastal Carolina Research Center Inc $78,749
  • Cra Headlands LLC $75,280
  • Ima Evaluations LLC DBA Ima Clinical Research $62,616
  • Suncoast Research Group LLC $60,751
  • Dynamed Philadelphia LLC $60,481
  • Helios Cr Inc $55,167
  • Tma Headlands LLC $53,289
  • Clinical Neuroscience Solutions Inc $50,767
  • Centennial Medical Group PA $46,976
  • Trial Management Associates LLC $45,858
  • Nature Coast Clinical Research $44,867
  • Synexus Clinical Research US Inc $42,854
  • Jbr Clinical Research LLC $38,444
  • Community Research Management Associates Inc $33,228
  • Be Well Clinical Studies LLC $31,891
  • Clinical Research PArtners LLC $30,185
  • Innovation Medical Research Center Inc $25,624
  • Great Lakes Clinical Trials LLC $25,589
  • Wr Crcn LLC $24,906
  • University Clinical Research Deland LLC $24,827
  • Elligo Health Research Inc $24,418
  • Texas Center for Drug Development Inc $23,922
  • Artemis Headlands LLC $22,168
  • Research Centers of America LLC $21,594
  • Palm Beach Research Center $21,297
  • Beautiful Minds Clinical Research Center $19,032
  • Achieve Clinical Research LLC $18,524
  • Brigham and Women's Hospital, MA $18,389
  • Phoenix Clinical LLC $14,550
  • Clinical Trials of Texas Inc $13,636
  • Cr Services Acquisition US LLC $12,032
  • Great Lakes Research Institute LLC $8,193
  • Clinical Trials of Texas LLC $8,162
  • Accel Research Sites-Ga LLC $7,992
  • Sweet Hope Research Speciality Inc $6,101
  • Health Research of Hampton Roads Inc $5,800
  • Clinical Innovations Inc $4,000
  • Elias Research Associates LLC $3,285
  • Institute for The Advancement of Clinical Trials LLC $2,918
  • Research Your Health LLC $2,904
  • Clinical Research Institute Inc $2,726
  • Eximia Research LLC $1,790

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.