A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have
Active, not recruiting · Phase 2 · NCT05831176
Conditions: Eosinophilic Gastritis (EoG), Eosinophilic Duodenitis (EoD), Eosinophilic Gastrointestinal Disease (EGID), Eosinophilic Gastroenteritis
At a glance
- Research payments reported, 2025
- $1.2M
- U.S. investigators named
- 38
- Sites paid
- 38
- Planned or actual enrollment
- 22
About the trial
- Sponsor
- Regeneron Pharmaceuticals (with Sanofi)
- Tested
- Dupilumab (drug)
- Dates
- Started 2023-05-03; completion 2026-11-25
- Results posted
- Not yet
This study is researching an experimental drug called dupilumab. The study is focused on participants with active eosinophilic gastritis (EoG) with or without eosinophilic duodenitis (EoD). Participants with EoD only are not eligible for enrollment. EoG and EoD are uncommon, persistent, allergic/immune diseases in which eosinophils (a type of white blood cell) gather in large numbers in the stomach and small intestine and cause inflammation and damage. The aim of the study is to evaluate the effect of dupilumab on relieving EoG (with or without EoD) symptoms and reducing inflammation in the stomach and, if applicable, small intestine in adults and adolescents aged 12 years and older after…
From ClinicalTrials.gov, last updated 2026-07-01. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Regeneron Pharmaceuticals, Inc. reported $1.2M in research payments for this study in 2025 (374 payments).
Products named: Dupixent
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Shauna Schroeder, MD Pediatric Gastroenterology · Phoenix, AZ
- Colby Sharlin, MD Pediatric Gastroenterology · Phoenix, AZ
- John J. Hong, MD Gastroenterology · Fallbrook, CA
- Nicholas Karyotakis, MD Gastroenterology · Los Angeles, CA
- Fouad J. Moawad, M.D. Internal Medicine · La Jolla, CA
- Jatinder S. Pruthi, M.D. Gastroenterology · Lancaster, CA
- Anisa Shaker, M.D. Gastroenterology · Los Angeles, CA
- Laura J. Wozniak, M.D. Pediatric Gastroenterology · Los Angeles, CA
- Houman Rezaizadeh, M.D. Gastroenterology · Farmington, CT
- Salam F. Zakko, MD Gastroenterology · Bristol, CT
- Ali Moghani Lankarani, MD Gastroenterology · Jacksonville, FL
- Yamen Smadi, M.D Pediatric Gastroenterology · Orlando, FL
- Rami G. El Abiad, M.D. Gastroenterology · Iowa City, IA
- Nirmala Gonsalves, MD Gastroenterology · Chicago, IL
- Salih Samo, M.D. Hospitalist · Chicago, IL
- John J. Lee, M.D. Allergy & Immunology · Boston, MA
- Trisha Pasricha, MD Gastroenterology · Boston, MA
- Navneet K. Virk Hundal, M.D. Pediatric Gastroenterology · Boston, MA
- Joan W. Chen, MD Gastroenterology · Ann Arbor, MI
- Benjamin L. Mitlyng, M.D. Student in an Organized Health Care Education/Training Program · Minneapolis, MN
- Thanai Pongdee, MD Allergy & Immunology · Rochester, MN
- Evan S. Dellon, M.D., M.P.H. Gastroenterology · Chapel Hill, NC
- David A. Leiman, MD Student in an Organized Health Care Education/Training Program · Durham, NC
- Jason A. Wilson, M.D. Gastroenterology · Charlotte, NC
- Andrew S. Huang-pacheco, M.D. Pediatric Gastroenterology · Omaha, NE
- Michael A. Curley, MD, FRCPC Gastroenterology · Lebanon, NH
- Sumodh C. Kalathil, M.D Gastroenterology · Reno, NV
- Guy A. Weiss, M.D. Gastroenterology · Buffalo, NY
- Subhankar Chakraborty, M.D. Gastroenterology · Columbus, OH
- Martha M. Tarpay, MD Allergy & Immunology · Oklahoma City, OK
- Phillip K. Kiyasu, MD Gastroenterology · Portland, OR
- Kristle L. Lynch Gastroenterology · Philadelphia, PA
- Jonathan M. Spergel, M.D. Pediatrics · Philadelphia, PA
- Rishi D. Naik, M.D. Gastroenterology · Nashville, TN
- Bankole O. Osuntokun, MD Pediatric Gastroenterology · Fort Worth, TX
- Kathryn A. Peterson, MD Gastroenterology · Salt Lake City, UT
- Michael K. Pickens, D.O. Pediatric Gastroenterology · Seattle, WA
- Patrick P. Sanvanson, MD Gastroenterology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- The University of North Carolina at Chapel Hill $203,362
- Cincinnati Children's Hospital Medical Center, OH $186,546
- Northwestern University $138,476
- Hospital of Univ of Pennsylvania, PA $103,894
- University of Michigan Health System, MI $63,624
- Duke University $59,059
- Mayo Clinic $45,104
- Boston Children's Hospital, MA $44,050
- Scripps Mercy Hospital, CA $37,656
- Cedars-Sinai Medical Center, CA $31,910
- University of Utah Hospital and Clinics, UT $30,594
- Resnick Neuropsychiatric Hospital at UCLA, CA $28,555
- Orlando Health, FL $23,520
- Beth Israel Deaconess Medical Center, MA $20,282
- Gastrointestinal Biosciences Clinical Trials LLC $19,570
- The Ohio State University $18,443
- United Medical Doctors $16,816
- University of Kansas Medical Center Research Institute Inc $16,030
- Advanced Research Inc $14,532
- University of Connecticut Health Center $13,945
- University of Iowa Hospital & Clinics, IA $13,717
- The Medical College of Wisconsin Inc $12,250
- Connecticut Clinical Research Institute LLC $12,016
- University of Southern California $7,626
- Encore Borland Groover Clinical Research LLC $7,500
- Seattle Children's Hospital, WA $6,486
- Children's Hospital of Philadelphia, PA $6,213
- $5,093
- Massachusetts General Hospital, MA $3,878
- Unehealth $3,764
- Vanderbilt University Medical Center, TN $3,500
- The Oregon Clinic PC $3,125
- Dartmouth Hitchcock Clinic $3,060
- Martha M Tarpay MD $2,533
- Phoenix Children's Hospital, AZ $1,900
- Charlotte Gastroenterology & Hepatology PLLC $1,500
- Om Research LLC $1,500
- Cook Childrens Health Care System $1,500
- Minnesota Gastroenterology PA $1,128
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.