Skip to main content

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

Active, not recruiting · Phase 3 · NCT05843643

Conditions: Systemic Lupus Erythematosus

At a glance

Research payments reported, 2025
$4.5M
U.S. investigators named
125
Sites paid
108
Planned or actual enrollment
1,014

About the trial

Sponsor
AbbVie
Tested
Upadacitinib (drug), Placebo (drug)
Dates
Started 2023-07-25; completion 2027-10
Results posted
Not yet

Systemic Lupus Erythematosus (SLE) is an immune-mediated disease associated with inflammation of multiple organ systems. This study will assess how safe and effective upadacitinib is in treating adult participants with moderately to severely active SLE. Adverse events and change in the disease activity will be assessed. Upadacitinib is an approved drug for rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis and is being developed for the treatment of SLE. This study is "double-blinded", which means that neither the trial participants nor the study doctors will know who will be given upadacitinib and who will be given placebo (does not contain treatment drug) . This study…

From ClinicalTrials.gov, last updated 2026-04-28. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $4.5M in research payments for this study in 2025 (783 payments).

Products named: Rinvoq

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Arizona Arthritis And $237,591
  • Cv Mehta MD Medical Corporation $139,059
  • Advanced Quality Medical Research $130,297
  • Sun Research Institute LLC $126,182
  • Paramount Medical Research $121,506
  • New York University $118,672
  • Caribbean Medical Research Center $111,921
  • Scla Management LLC $111,889
  • Clinical Research of West Florida $100,313
  • Corazon USA LLC $98,418
  • Jps Health Network, TX $97,031
  • Univ of Florida Board of Trustees $91,730
  • Sweet Hope Research Specialty Inc $90,458
  • Arthritis and Rheumatology $87,563
  • Gcm Medical Group Psc $83,862
  • David S Hallegua MD A Prof Corp $80,350
  • Emory University Hospital, GA $78,281
  • Hmd Research LLC $76,974
  • Biopharma Informatic LLC $73,557
  • Mindful Medical Research $72,151
  • Omega Research Debary LLC $67,514
  • Arizona Arthritis & Rheumatology $66,011
  • Harac Research $65,467
  • Regents of the Univ of California $65,059
  • Providence Health System - Southern $60,450
  • Hernandez & Trujillo LLC $59,718
  • Upland Rheumatology Clinical Trials $55,791
  • Deerbrook Medical Associates $55,561
  • Newport Huntington Medical Group $54,767
  • Millennium Research LLC $51,907
  • Norman B Gaylis MD PA $51,588
  • Yale University $50,084
  • Joint and Muscle Research Institute $47,551
  • Epic Medical Research $47,422
  • Clinical Research Investigator $46,936
  • Wallace Rheumatic $46,725
  • Wcg Clinical Inc $45,792
  • Naiara M Alvarez MD PA $43,426
  • Scla Management Inc $43,302
  • Arthritis & Osteo Medical Ctr $41,816
  • Gnp Consultants LLC $40,276
  • University of Cincinnati $39,632
  • Northwestern University $38,735
  • Trinity Universal Research Associat $38,337
  • Next Innovative Clinical Research $37,774
  • Health Group of America LLC $35,760
  • Finlay Medical Research Corp $35,304
  • West Tennessee Research Institute $33,295
  • The University of Chicago $31,542
  • Orthomidwest PLLC $31,425
  • Jacksonville Ctr for Clinical Rsrch $31,133
  • Novamed Research LLC $30,746
  • Rasf Clinical Research Inc $29,607
  • University of Pittsburgh Physicians $27,300
  • Maryland Board of Pharmacy $27,200
  • Providence Medical Foundation $25,525
  • Amal Mehta MD Apmc $24,327
  • St Lawrence Health System Inc $24,152
  • Shelby Research LLC $23,808
  • Aa Mrc LLC $23,598
  • University of Illinois Hospital and Clinics, IL $23,322
  • Rao Research LLC $21,979
  • Advanced Clinical Research Center $21,676
  • Atlanta Research Center for $21,440
  • Arthritis and Rheumatology Centerpc $21,265
  • Millennium Clinical Trials LLC $20,747
  • Willow Rheumatology and Wellness $20,736
  • Accurate Clinical Research Inc $20,731
  • Oklahoma Med Research Foundation $19,972
  • Rheumatology and Pulmonary Clinic $19,916
  • Western Ky Rheumatology PLLC $19,359
  • State of Maryland $19,272
  • Medical College of Wisconsin $18,874
  • Iris Research and Development LLC $18,710
  • Accellacare US Inc $18,666
  • Evolution Research Network LLC $18,655
  • Carilion Medical Center, VA $18,286
  • Clinical Research Institute Of $17,080
  • Baycare Health System Inc $15,692
  • Wake Forest University $15,517
  • R & H Clinical Research Inc $15,338
  • Solace Clinical Research LLC $15,060
  • Djl Clinical Research PLLC $14,950
  • Mdr Core Network Inc $14,500
  • Hillary E Norton MD PC $14,351
  • Christine Hsin-Ying Lee $12,550
  • Urban Health Plan Inc $12,275
  • Dynamed Clinical Research LP $11,849
  • Ezy Medical Research Co $11,000
  • Dartmouth Hitchcock Health $10,891
  • Clinical Trials of Texas LLC $10,562
  • University of Miami $10,409
  • University of Massachusetts $10,321
  • Accurate Clinical Management LLC $10,000
  • $9,600
  • Articularis Healthcare Grp Inc $8,683
  • Thomas Jefferson University $8,500
  • Illinois Bone and Joint $8,100
  • International Medical Research LLC $8,037
  • Honorhealth Scottsdale Osborn Medical Center, AZ $5,000

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.