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A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

Active, not recruiting · Phase 3 · NCT05889182

Conditions: Hidradenitis Suppurativa

At a glance

Research payments reported, 2025
$3.3M
U.S. investigators named
84
Sites paid
80
Planned or actual enrollment
1,328

About the trial

Sponsor
AbbVie
Tested
Upadacitinib (drug), Placebo (drug)
Dates
Started 2023-06-21; completion 2028-09
Results posted
Not yet

Hidradenitis suppurativa (HS) is an inflammatory skin disease that causes painful lesions in the axilla (underarm), inguinal (groin) and anogenital (anal/genital) regions. This study will assess how safe and effective upadacitinib is in treating adult and adolescent participants with moderate to severe HS who have failed to respond to or are intolerant of anti-tumor necrosis factor (TNF) therapy. Adverse events and change in disease activity will be assessed. Upadacitinib is an approved drug for ulcerative colitis, atopic dermatitis, rheumatoid arthritis, psoriatic arthritis, and axial spondylarthritis and is being developed for the treatment of HS. This study is "double-blinded", meaning…

From ClinicalTrials.gov, last updated 2026-08-20. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $3.3M in research payments for this study in 2025 (616 payments).

Products named: Rinvoq

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Integrative Skin Science $192,708
  • Skin Care Research Inc $160,215
  • Dermatology and Skin Cancer $148,205
  • Southwest Skin Specialists LLC $123,800
  • Clinohio Research Services $109,410
  • Cr Services Acquisition US LLC $108,826
  • University of Utah Hospital and Clinics, UT $108,816
  • Clinical Trials Research Institute $85,568
  • Equity Medical LLC $76,372
  • T Joseph Raoof MD Inc $73,863
  • University of Connecticut $69,834
  • Dermatologists of Southwest Ohio $69,368
  • Texas Dermatology Research Center $68,740
  • Las Vegas Dermatology $67,798
  • Mayo Clinic Hospital, AZ $66,811
  • Clinical Research Philadelphia LLC $65,216
  • St Louis University $55,799
  • Dr Samuel Sanchez Psc $54,589
  • Denova Research $54,313
  • Cahaba Derm & Skin Health Ctr LLC $54,113
  • Treasure Valley Medical Research $53,815
  • Apex Clinical Research Center LLC $53,612
  • The University of Arizona $52,547
  • Duke University $51,888
  • Cory J Rubin MD PC $51,215
  • The Feinstein Institute for Medical Research $49,493
  • Fife Dermatology PC $46,848
  • Bellaire Dermatology Associates $45,917
  • Modern Research Associates PLLC $45,038
  • University of Massachusetts $44,361
  • Mountain West Derm-Blackhart PLLC $43,259
  • Center for Clinical Studies LTD LLP $42,796
  • Ohsu Hospital and Clinics, OR $42,257
  • Florida Academic Centers $40,844
  • North Sound Dermatology $40,125
  • Pflugerville Dermatology Clinical $39,312
  • Norcal Clinical Research $38,928
  • Yale University $38,234
  • Washington University $36,489
  • Corazon USA LLC $35,927
  • Dawes Fretzin Clinical Research $35,594
  • Alma M Cruz-Santana $33,240
  • Qcare Site Services Inc $33,000
  • Medisearch Clinical Trials $31,644
  • Clinical Trials Institute Of $29,947
  • Virginia Clinical Research Inc $29,519
  • Randall Dermatology $26,256
  • Medical University South Carolina $26,226
  • Pennsylvania State University $24,445
  • Burke Pharmaceutical Research $23,613
  • Derm Institute of West Michigan $23,299
  • Northwestern University $22,732
  • Arkansas Research Trials LLC $21,955
  • Michigan Center for Research $19,144
  • Massachusetts General Hospital, MA $17,588
  • Hrmd Research $17,377
  • Advanced Clinical Research Institute $16,776
  • Lynn Health Science Institute $16,058
  • Onsite Clinical Solutions LLC $15,414
  • Medderm Corporation $14,564
  • Northshore University Healthsystem - Evanston Hospital, IL $14,438
  • Beacon Clinical Research LLC $12,054
  • Peak Dermatology Aesthetics and Wellness Fountain Hills $11,868
  • Apex Clinical Trials $11,340
  • Dermatology Assoc of Knoxville $11,070
  • Marvel Clinical Research 002 LLC $10,683
  • Interspond LLC $9,832
  • Northwest Arkansas Clinical $9,263
  • Cleaver Dermatology PC $8,283
  • Bobby Buka MD Professional $8,133
  • Schweiger Dermatology PC $6,872
  • University of Virginia Medical Center, VA $6,592
  • University of California Davis Medical Center, CA $6,275
  • Arlington Research Center Inc $5,689
  • Iltefat Hamzavi $5,102
  • Arano PLLC $4,631
  • Dermatology Research Associates Inc $3,896
  • Avita Clinical Research LLC $3,750
  • Dallas Fort Worth Clinical Research $3,625
  • Dermatology Treatment And $3,597

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.