A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
Completed · Phase 3 · NCT05929079
Conditions: Type 2 Diabetes, Obesity, Overweight, Obstructive Sleep Apnea
At a glance
- Research payments reported, 2025
- $5.5M
- U.S. investigators named
- 50
- Sites paid
- 48
- Planned or actual enrollment
- 1,152
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- Retatrutide (drug), Placebo (drug)
- Dates
- Started 2023-07-11; completion 2026-06-16
- Results posted
- Not yet
The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have obesity or overweight (J1I-MC-GZBK master protocol) including a subset of participants who have obstructive sleep apnea (OSA) (J1I-MC-GSA2). The study will last about 89 weeks and will include up to 24 visits.
From ClinicalTrials.gov, last updated 2026-07-30. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $5.5M in research payments for this study in 2025 (105 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Almena Free, M.D. Internal Medicine · Anniston, AL
- Randall L. Quinn, MD Family Medicine · Cullman, AL
- Jitendra Sharma, M.B.B.S Neurology · Birmingham, AL
- Paul E. Wylie, M.D. Psychiatry · Little Rock, AR
- Francisco L. Badar III, MD Family Medicine · Cerritos, CA
- Christopher G. Chow, MD Internal Medicine · Northridge, CA
- David L. Guzman, D.P.M. Podiatrists · Napa, CA
- David Guzman, M.D. Internal Medicine · Los Angeles, CA
- Jeffrey S. Overcash, MD Emergency Medicine · Chula Vista, CA
- Helen L. Stacey, MD Internal Medicine · Walnut Creek, CA
- Jenna E. Langello, PA-C Physician Assistants · Waterbury, CT
- George P. Azar JR., M.D., PA Critical Care Medicine · Ft Lauderdale, FL
- Mira Baron, MD, CPI Internal Medicine · West Palm Beach, FL
- Alfonso Gonzalez-rodriguez, MD Internal Medicine · Orlando, FL
- Raj G. Karunakara, M.D. Pulmonology · Ocala, FL
- Howard S. Koch, MD Internal Medicine · Sunrise, FL
- Ryan A. Lamarca, M.D. Nephrology (Kidney) · Fort Lauderdale, FL
- Daniel G. Lorch, M.D. Pulmonology · Brandon, FL
- Mark J. Rosenthal, D.O. Family Medicine · Homestead, FL
- Mitchell S. Rothstein, MD Pulmonology · Jacksonville, FL
- Rasha R. Youssef, M.D. Family Medicine · Boynton Beach, FL
- Dennis M. Lacey, MD Neurology · Atlanta, GA
- Maria C. Mascolo, MD Pulmonology · Rincon, GA
- Cindy H. Pau, MD Endocrinology & Diabetes · Honolulu, HI
- Blair Brengle, MD Family Medicine · Indianapolis, IN
- James P. Maynard, M.D. Neurology · Fort Thomas, KY
- David J. Dibenedetto, M.D. Pain Medicine · Waltham, MA
- Timothy R. Smith, M.D. Internal Medicine · Saint Peters, MO
- Awawu E. Igbinadolor, M.D. Adolescent Medicine · Monroe, NC
- Mary K. Lawrence, MD Endocrinology & Diabetes · Morehead City, NC
- Michael J. Lillestol, M.D. Internal Medicine · Fargo, ND
- Cornell V. Calinescu, MD Emergency Medicine · Las Vegas, NV
- Sashi K. Makam, MD Internal Medicine · New Windsor, NY
- Andrew N. Abboud Student in an Organized Health Care Education/Training Program · Cleveland, OH
- Agam Bansal, MD Internal Medicine · Cleveland, OH
- Vincent Chen, MD Cardiology · Cleveland, OH
- Bruce C. Corser, MD Pulmonology · Cincinnati, OH
- Alejandro Duran Crane, MD Internal Medicine · Cleveland, OH
- Medhat Farwati, MD Student in an Organized Health Care Education/Training Program · Cleveland, OH
- Paul Hartley, M.D. Internal Medicine · Uniontown, PA
- Samuel Kelly, MD Cardiology · Philadelphia, PA
- Bryce Palchick, M.D. Family Medicine · Pittsburgh, PA
- Christopher M. Davis, DO Family Medicine · Greenville, SC
- Donald Eagerton, M.D. Endocrinology & Diabetes · Myrtle Beach, SC
- Ronald K. Mayfield, M.D. Endocrinology & Diabetes · Spartanburg, SC
- John D. Hudson, M.D. Sleep Medicine · Austin, TX
- Julio Rosenstock, M.D. Endocrinology & Diabetes · Dallas, TX
- Michael D. Woolman, MD Family Medicine · Ogden, UT
- Gaylon Kipp, MD Family Medicine · Bellevue, WA
- Nazia H. Rahman, M.D. Pediatrics · Bellevue, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Clinical Research of Broward County DBA Clinical Research Center of Florida $425,787
- Valley Clinical Trials Inc $326,928
- Renstar Inc $306,370
- Velocity Clinical Research Inc $282,114
- Teradan Clinical Trials LLC $251,728
- Lillestol Research LLC $247,200
- Sociedad Espanola De Medicina De La Adolescencia $228,938
- Palm Beach Research Center $215,346
- Cti Holdings Inc DBA Community Research Management Associates Inc $215,167
- Studymetrix Research LLC $207,799
- Quantum Clinical of Dade County, DBA Quantum Clinical Trials $199,358
- Compass Point Research Inc $188,050
- Futuresearch Trials of Neurology LP $180,017
- Las Vegas Medical Research LLC $177,830
- Tribe Clinical Research LLC $165,119
- Northwest Clinical Research Center $154,073
- Advanced Research Inc $144,163
- Clinical Site PArtners LLC $134,781
- Therafirst Medical Centers Inc $132,046
- Medvadis Research Corp LLC $118,175
- Cr Services Acquisition US LLC $117,414
- David Fitzpatrick MD DBA E West Med Rsrch $108,311
- Chase Medical Research LLC $106,226
- Preferred Primary Care Physicians Inc $103,128
- Carteret Medical Group LLC $102,760
- Wrightsville Family Practice $95,187
- Pinnacle Research Group LLC $88,211
- Jacksonville Center for Clinical Research $69,974
- Intrepid Research LLC $65,559
- Flourish Research Acquisition LLC $50,886
- Mid Hudson Medical Research PLLC $46,398
- Baptist Health $44,886
- Dr Dennis M Lacey $41,492
- Monroe Biomedical Research $35,306
- Francisco Badar MD Inc $31,075
- Cullman Clinical Trials $26,755
- $3,799
- Dallas Diabetes and Endo Research Center PA $2,406
- Mehrdad Kevin Ariani MD $1,811
- Cleveland Clinic, OH $1,768
- Clinical Research Center of Florida $1,285
- Advanced Research Institute $1,148
- Mountain View Clinical Research Inc $1,103
- Columbus Clinical Research Inc $752
- Future Search Trials of Dallas LP $570
- Excel Medical Clinical Trials, LLC $500
- Care Access Research LLC $341
- Andrew J Lewin Med DBA National Rsrch Institute $105
- Cti-Crc $15
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.