Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
Recruiting · Phase 3 · NCT05943535
Conditions: Progressive Pulmonary Fibrosis, Interstitial Lung Disease
At a glance
- Research payments reported, 2025
- $3.2M
- U.S. investigators named
- 67
- Sites paid
- 63
- Planned or actual enrollment
- 698
About the trial
- Sponsor
- United Therapeutics
- Tested
- Placebo (drug), Inhaled Treprostinil (drug), Treprostinil Ultrasonic Nebulizer (device)
- Dates
- Started 2023-10-30; completion 2027-11
- Results posted
- Not yet
Study RIN-PF-305 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with progressive pulmonary fibrosis (PPF) over a 52-week period.
From ClinicalTrials.gov, last updated 2026-07-13. Full record, eligibility and contacts (opens in a new tab)
Industry funding
United Therapeutics Corporation reported $3.2M in research payments for this study in 2025 (798 payments).
Products named: Tyvaso
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Tejaswini Kulkarni Pulmonology · Birmingham, AL
- Shehabaldin Alqalyoobi, M.D. Critical Care Medicine · Scottsdale, AZ
- Rajat Walia, MD Pulmonology · Phoenix, AZ
- Daniel S. Jones, M.D. Internal Medicine · La Jolla, CA
- Ryan M. Klein, MD Internal Medicine · Newport Beach, CA
- Rafael Lupercio, M.D. Critical Care Medicine · Redding, CA
- Rishi Raj, M.D. Critical Care Medicine · Stanford, CA
- Namita Sood, M.D. Pulmonology · Sacramento, CA
- Stephen S. Weigt, MD Pulmonology · Los Angeles, CA
- Bassam Yaghmour, M.D. Critical Care Medicine · Orange, CA
- Cristina Reichner Critical Care Medicine · Washington, DC
- Debabrata Bandyopadhyay, MD Critical Care Medicine · Orlando, FL
- Jose D. Herazo-maya, M.D Pulmonology · Naples, FL
- Augustine Lee, MD Pulmonology · Jacksonville, FL
- Akram M. Shibani, MD Pulmonology · Jacksonville, FL
- Amy H. Case, MD Pulmonology · Austell, GA
- Srihari Veeraraghavan, M.D. Pulmonology · Atlanta, GA
- Bradford Bemiss, MD Pulmonology · Maywood, IL
- Daniel Dilling, MD Critical Care Medicine · Maywood, IL
- Dustin R. Fraidenburg, M.D. Pulmonology · Chicago, IL
- Mark Yoder, M.D. Pulmonology · Chicago, IL
- Sahil M. Pandya, M.D. Pulmonology · Kansas City, KS
- Girish Nair, MD Pulmonology · Lexington, KY
- Mohamed Saad, MD Pulmonology · Louisville, KY
- Parijat Sen, M.D. Pulmonology · Lexington, KY
- Joseph Lasky, MD Pulmonology · New Orleans, LA
- Leo C. Ginns, MD Pulmonology · Boston, MA
- Curtis J. Mello, MD Pulmonology · North Dartmouth, MA
- Jonathan B. Cohen, M.D. Internal Medicine · Rockville, MD
- Matthew Lammi, MD Pulmonology · Baltimore, MD
- Enrique Calvo Ayala, M.D. Pulmonology · Royal Oak, MI
- Hyun Joo Kim, MD Pulmonology · Minneapolis, MN
- Teng Moua, M.D. Pulmonology · Rochester, MN
- Neil Ettinger, MD Pulmonology · Chesterfield, MO
- Tonya D. Russell, MD Pulmonology · Saint Louis, MO
- Mark B. Yagan, M.D. Pulmonology · Kansas City, MO
- Benjamin J. Bregman, M.D. Critical Care Medicine · Winston Salem, NC
- Veeranna Maddipati, M.D.,M.BB.S Pulmonology · Greenville, NC
- Lake D. Morrison, MD Pulmonology · Durham, NC
- Murali Ramaswamy, MD FAAFP Pulmonology · Greensboro, NC
- Nour A. Ass'ad, M.D. Internal Medicine · Albuquerque, NM
- Alpa G. Desai, M.D. Pulmonology · Stony Brook, NY
- Ali Mansour, MD Internal Medicine · Bronx, NY
- Anna Podolanczuk, M.D. Critical Care Medicine · New York, NY
- Arunabh Talwar, MD Pulmonology · New Hyde Park, NY
- Nitin Y. Bhatt, MD Pulmonology · Columbus, OH
- Nishant Gupta, M.D. Pulmonology · Cincinnati, OH
- Vinod Khatri, M.D. Internal Medicine · Toledo, OH
- Michaela R. Anderson, M.D. Pulmonology · Philadelphia, PA
- Rebecca Bascom, M.D. Pulmonology · Hershey, PA
- Parth M. Rali, MD Pulmonology · Philadelphia, PA
- Abhinav Gupta, M.D. Critical Care Medicine · Columbia, SC
- Rachana Krishna, M.D. Pulmonology · Charleston, SC
- Justin C. Hewlett, MD Pulmonology · Nashville, TN
- Aaron Milstone, MD Pulmonology · Franklin, TN
- Eric M. Weaver, MD Pulmonology · Knoxville, TN
- Rodeo A. Abrencillo, M.D. Critical Care Medicine · Houston, TX
- Alfredo R. Arauco Brown, M.D. Pulmonology · Weslaco, TX
- Shahrukh A. Kureishy, MD Pulmonology · Mckinney, TX
- Margaret A. Kypreos, M.D. Pulmonology · Dallas, TX
- Sandeep Sahay, MD Pulmonology · Houston, TX
- Yosafe Wakwaya, M.D. Pulmonology · Dallas, TX
- Peter F. Crossno, MD Critical Care Medicine · Murray, UT
- Shilpa Johri, MD Pulmonology · Richmond, VA
- Christopher S. King, MD Critical Care Medicine · Falls Church, VA
- Mark Barash, D.O. Pulmonology · Milwaukee, WI
- Stephen J. Halliday, M.D., MSCI Pulmonology · Madison, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Kumc Research Institute Inc $172,698
- A and A Research Consultants LLC $172,138
- Medical University of South Carolina $147,077
- Mayo Clinic $127,303
- The Methodist Hospital Research Institute $111,887
- The Johns Hopkins University $109,335
- Intermountain Health Utah Valley Hospital, UT $97,610
- Beaumont Hospital - Grosse Pointe, MI $88,145
- Massachusetts General Hospital, MA $85,104
- The Washington University $82,460
- Pulmonary Assoc of Richmond Inc $82,194
- Mayo Clinic Jacksonville $81,532
- Biomedical Research Alliance of New York LLC $81,059
- The University of South Florida $80,108
- University of California Davis Medical Center, CA $74,091
- Hospital of Univ of Pennsylvania, PA $73,485
- Inova Loudoun Hospital, VA $69,729
- Newportnativemd Inc $66,999
- Paradigm Clinical Rsrch Centers Inc $64,064
- University of Alabama Hospital, AL $63,817
- University of Cincinnati $63,813
- The Administrators of the Tulane Educational Fund $63,232
- Mayo Clinic Hospital, AZ $60,162
- Medical College of Wisconsin Inc $58,465
- Center for Biomedical Research $53,798
- Southeastern Research Center LLC $50,468
- Northwestern University $50,177
- Weill Medical College of Cornell University $49,535
- The Board of Trustees of the Leland Stanford Junior University $45,938
- Baylor Research Institute $45,315
- Duke University Department of Medicine $44,463
- Loyola University of Chicago $44,342
- Temple University of the Commonwealth System of Higher Education $41,313
- The Ohio State University $40,375
- Pulmonix, LLC $38,839
- Pennsylvania State University $37,600
- The University of Texas Health $33,944
- St Josephs Hospital and Medical Center, AZ $32,006
- University of Wisconsin and Visual Sciences $31,636
- University of New Mexico Hsc $30,972
- St Vincents Health System Inc $30,836
- St Lukes Hospital of Kansas City, MO $28,200
- Ronald Reagan UCLA Medical Center, CA $27,825
- University of Illinois Hospital and Clinics, IL $26,489
- Ut MD Anderson Cancer Center $26,361
- The Research Foundation Suny $25,966
- Clinical Trials Center of Middle Tennessee $25,567
- Adventist Healthcare Inc $25,191
- University of Louisville Research Foundation Inc $23,706
- Prisma Health Richland Hospital, SC $18,608
- Metroplex Pulmonary and Sleep Center $17,520
- Piedmont Healthcare, Inc. $16,720
- University of Kentucky Research $14,999
- Rush University Medical Center, IL $13,928
- The Lung Research Center LLC $12,680
- Infinity Medical Research Inc. $11,595
- Emory University Hospital, GA $10,992
- Vanderbilt University Medical Center, TN $10,600
- East Carolina University $9,624
- Bon Secours Mercy Health Inc $9,092
- Georgetown University $8,450
- Regents of the University of Minnesota $1,840
- $1,516
- The University of Texas Southwestern Medical Center $1,500
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.