A Study of Orforglipron (LY3502970) in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone
Completed · Phase 3 · NCT05971940
Conditions: Type 2 Diabetes
At a glance
- Research payments reported, 2025
- $1.1M
- U.S. investigators named
- 48
- Sites paid
- 48
- Planned or actual enrollment
- 559
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- Orforglipron (drug), Placebo (drug)
- Dates
- Started 2023-08-09; completion 2025-04-03
- Results posted
- Yes
The main purpose of this study is to determine safety and efficacy of orforglipron compared with placebo in adult participants with type 2 diabetes and inadequate glycemic control with diet and exercise alone. The study will last approximately 54 weeks.
From ClinicalTrials.gov, last updated 2026-09-03. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $1.1M in research payments for this study in 2025 (89 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Aaron W. Karr, D.O. Family Medicine · Sheffield, AL
- Jitendra Sharma, M.B.B.S Neurology · Birmingham, AL
- Rachel Greatwood, D.O. Family Medicine · Mesa, AZ
- Walter S. Patton JR., MD OB-GYN (Obstetrics & Gynecology) · Tucson, AZ
- David L. Guzman, D.P.M. Podiatrists · Napa, CA
- Stanley Hsia, M.D. Endocrinology & Diabetes · Los Angeles, CA
- John H. Kim, M.D. OB-GYN (Obstetrics & Gynecology) · Union City, CA
- Peter N. Mattar, MD Family Medicine · Fontana, CA
- Martha G. Navarro, MD Family Medicine · Redondo Beach, CA
- James Schultz, M.D Family Medicine · Escondido, CA
- Yshay Shlesinger, M.D. Internal Medicine · San Ramon, CA
- Charles B. Montano, MD Internal Medicine · Cromwell, CT
- John M. Hill, MD Family Medicine · Deland, FL
- Jose M. Mandry, M.D. Endocrinology & Diabetes · Ocoee, FL
- Neel R. Patel, M.D. Cardiology · Maitland, FL
- Maray Rocher, M.D Internal Medicine · Miami, FL
- Juan Zapata, M.D. Internal Medicine · Wellington, FL
- Dwight D. Blake, MD Internal Medicine · Union City, GA
- Jon P. Finley, M.D. Sports Medicine · Stockbridge, GA
- Flint R. Packer, D.O. Family Medicine · Idaho Falls, ID
- Jonathan D. Condit, DO Family Medicine · Muncie, IN
- Brandon W. Alleman, MD Family Medicine · Wichita, KS
- Abdulhassan Saad, M.D. Internal Medicine · Dearborn, MI
- Henry J. Youga, MD Family Medicine · Manistee, MI
- Lauren E. Kleess, M.D. Endocrinology & Diabetes · Billings, MT
- Awawu E. Igbinadolor, M.D. Adolescent Medicine · Monroe, NC
- Robert J. Noveck, MD Clinical Pharmacology · Durham, NC
- Claire Presswood Internal Medicine · Morehead City, NC
- Trent L. Wei, MD Interventional Cardiology · Greensboro, NC
- Jorge Serje, M.D. Internal Medicine · Brooklyn, NY
- Jon C. Stringer, M.D. Internal Medicine · Manlius, NY
- Robert E. Dunn, MD Cardiac Electrophysiology · Cleveland, OH
- Medhat Farwati, MD Student in an Organized Health Care Education/Training Program · Cleveland, OH
- Lisa B. Connery, M.D. Family Medicine · Norman, OK
- Patricia S. Hopson, DO Endocrinology & Diabetes · Corvallis, OR
- Daniel Austin, D.O. Family Medicine · Pittsburgh, PA
- Paul Hartley, M.D. Internal Medicine · Uniontown, PA
- Elham S. Ghorbani, MD General Practice · Dorado, PR
- Orvil Martinez, MD General Practice · Utuado, PR
- Harlicia Farley, MD Family Medicine · Greenville, SC
- Amrendra Kumar, MD Family Medicine · Lancaster, SC
- Zackary D. Goff, M.D. Cardiology · Nashville, TN
- Kellie L. Wallace-wilding, MD Family Medicine · Jackson, TN
- Amer Al-karadsheh, M.D. Endocrinology & Diabetes · Houston, TX
- Amir A. Hassan, M.D. P.A. Endocrinology & Diabetes · Houston, TX
- Dan Lender, MD Endocrinology & Diabetes · Rockwall, TX
- Damaris Vega, MD Endocrinology & Diabetes · Houston, TX
- Nashwa W. Gabra, M.D. Internal Medicine · Burke, VA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- C and S Health Center $112,432
- Corvallis Clinic PC $60,887
- Ark Clinical Research LLC $59,136
- Mdfirst Research LLC $56,406
- Family First Medical Center $55,166
- K2 Medical Research LLC $50,358
- Syed Research Consultants LLC $45,177
- Preferred Primary Care Physicians Inc $43,802
- Hillcrest Medical Research $43,660
- Velocity Clinical Research Inc $43,563
- Invictus Clinical Research Group LLC $33,395
- Infinity Clinical Research $32,431
- Juno Research LLC $31,982
- Biopharma Informatic Inc Research Center $29,824
- The Research Center of the Upstate $29,468
- Puerto Rico Health and Wellness Institute $27,477
- Revival Research Institute LLC $25,466
- Alliance for Multispecialty Research Lls $25,118
- Cleveland Clinic, OH $24,890
- Monroe Biomedical Research $24,198
- Neighborhood Healthcare $23,840
- Epic Medical Research $23,326
- Yshay Shlesinger MD $22,837
- Sky Clinical Research Network Group $22,692
- Clinical Research Atlanta $22,516
- Cr Services Acquisition US LLC $22,441
- Elligo Health Research Inc $22,167
- Jackson Clinic PA $17,423
- West Orange Endocrinology PA $17,422
- American Health Network of in LLC $13,304
- Burke Internal Medicine Inc, DBA Manassas Clinical Research Cent $11,728
- Total Medical Care $10,124
- University Clinical Investigators Inc $7,729
- Quality of Life Medical and Research $6,732
- Lucas Research Inc $6,500
- Endocrine Ips PLLC $6,284
- Billings Clinic Hospital, MT $5,910
- Andrew J Lewin Med DBA National Rsrch Institute $520
- Atlanta Cardiology Associates LLC $400
- Puerto Rico Health Institute LLC $360
- Diabetes and Endocrinology Consultants $360
- Tekton Research Inc $331
- Central New York Medical Research $325
- Pharmacology Research Institute $260
- Intend Research LLC $260
- Columbus Clinical Research Inc $260
- Connecticut Clinical Research Institute LLC $260
- Advance Medical Research Center LLC $65
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.