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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Recruiting · Phase 3 · NCT05980949

Conditions: Psychosis Associated With Alzheimer's Disease

At a glance

Research payments reported, 2025
$10.4M
U.S. investigators named
90
Sites paid
82
Planned or actual enrollment
1,000

About the trial

Sponsor
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Tested
KarXT (drug)
Dates
Started 2023-07-11; completion 2027-09-07
Results posted
Not yet

This is a Phase 3 global, multicenter, 52-week, open-label extension (OLE) rollover study for subjects completing study CN012-0026, CN012-0027 or CN012-0056. Subjects (randomized or non-randomized) who complete the 38-week CN012-0026 study, 14-week CN012-0027 study or 14-week CN012-0056 study will be eligible to enroll in CN012-0028. The primary objective of the study is to assess the long-term safety and tolerability of KarXT in subjects with psychosis associated with Alzheimer's Disease.

From ClinicalTrials.gov, last updated 2026-10-16. Full record, eligibility and contacts (opens in a new tab)

Industry funding

E.r. Squibb & Sons, L.l.c. reported $10.4M in research payments for this study in 2025 (107 payments).

Products named: Cobenfy

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Elias Research Associates Llc $3.6M
  • Clinitiative Health Research $733,152
  • Integrity Clinical Research $639,493
  • Mplusm Consulting Llc $614,025
  • Future Care Solution, Llc $599,495
  • Medone Clinical Research $538,136
  • Allied Biomedical Research Institute $317,836
  • Pharmaseek $302,140
  • Betancourt Research Services $245,460
  • Homestead Associates in Research, Inc $180,487
  • Floridian Neuroscience Institute $180,034
  • Ocean Blue Medical Research Center, Incorporated $157,477
  • Guardian Angel Research Center $145,339
  • Coral Clinic Research $141,994
  • Premier Clinical Research Institute $140,266
  • Horizon Clinical Research Group $131,517
  • Meridian International Research, Inc $119,971
  • On Health Research $110,651
  • Imic Research $95,300
  • Novel Clinical Research Center, Llc $78,486
  • San Marcus Research Clinic, Inc $66,023
  • Galiz Research, Llc $62,358
  • Direct Helpers Research Center $55,709
  • Erg Holding Company Llc $55,070
  • Reliant Medical Research $54,967
  • Las Mercedes Medical Research - 4440 West 16th Avenue $54,179
  • Sc3 Research Group, Inc $53,709
  • K2 Medical Research - Maitland $51,859
  • Ccm Clinical Research Group $49,251
  • Noir Research Collective Llc $48,839
  • New Gen Health and Research Group $42,538
  • Superior Associates in Research Llc $34,965
  • $33,039
  • Ohio State University Resear Fo $33,024
  • Revival Research Institute, Inc $33,000
  • Us Associates in Research, Llc $28,068
  • High Quality Research $27,692
  • Sunwise Clinical Research $27,278
  • Clinical Trial Network, Llc $26,485
  • Angels Clinical Research Institute Tampa - PAlm Springs - Ppds $25,499
  • Envision Trials, Llc $25,108
  • Long Beach Research Institute $25,044
  • Banner Casa Grande Medical Center, AZ $24,100
  • Advanced Research Center $22,767
  • Nexus Clinical Research Center- Nrc $22,755
  • K2 Medical Research - Winter Garden $21,599
  • Conquest Research, Llc $20,923
  • Rhode Island Hospital, RI $20,500
  • The Feinstein Institute for Medical Research $19,760
  • Arrow Clinical Trials $19,076
  • Five Towns Neurology, PC $18,755
  • Barbara Diaz Hernandez, MD Research, Inc $18,488
  • Alzheimers Memory Center Flourish Research $18,381
  • Prospective Research Innovations, Inc $15,000
  • Premiere Research Institute $15,000
  • Recinto De Ciencias Medical $14,500
  • Mclean Hospital Corporation, MA $14,450
  • The Ima Group $14,000
  • Chandler Clinical Research Trials $14,000
  • Aim Trials $13,657
  • Clincloud Llc $13,341
  • Interspond, Llc $13,050
  • Agile Clinical Research Trials $11,500
  • California Neuroscience Research Medical Group, Inc $11,344
  • Usc Norris Cancer Hospital $10,500
  • M3 Wake Research $6,600
  • Georgia Health Sciences University $6,500
  • Mdfirst Research $6,100
  • University Clinical Research - Deland, Llc $3,095
  • Health Synergy Clinical Research $1,180
  • Vanderbilt Psychiatric Hospital $486
  • Aqualane Clinical Research $337
  • Cordova Research Institute $336
  • Elixia Health - Springfield - Elixia - Ppds $277
  • Tufts Medical Center - 800 Washington St - Ppds $236
  • Precise Research Center $204
  • Conquest Research - Arlington $182
  • Usc - the Memory and Aging Center (mac) - Alzheimer Disease Research Center (adrc) $182
  • Boston Neuro Research Center $164
  • Sensible Healthcare, Llc $139
  • Rivus Wellness and Research Institute $125
  • Advanced Memory Research Institute of New Jersey $51
  • Cdt Grupo Medico San PAblo $39

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.