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A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

Recruiting · Phase 3 · NCT06012240

Conditions: Alopecia Areata

At a glance

Research payments reported, 2025
$1.7M
U.S. investigators named
70
Sites paid
110
Planned or actual enrollment
1,500

About the trial

Sponsor
AbbVie
Tested
Upadacitinib (drug), Placebo (drug)
Dates
Started 2023-10-11; completion 2030-04
Results posted
Not yet

Alopecia areata (AA) is a disease that happens when the immune system attacks hair follicles and causes hair loss. AA usually affects the head and face, but hair loss can happen on any part of the body. The purpose of this study is to assess how safe, effective, and tolerable upadacitinib is in adolescent and adult participants with severe AA. Upadacitinib is an approved drug being investigated for the treatment of AA. In Study 1 and Study 2 and Study 4 Period A, participants are placed in 1 of 3 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 5 chance that participants will be assigned to placebo. In Study 1 and Study 2 and Study 4 Period B, part…

From ClinicalTrials.gov, last updated 2026-10-19. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $1.7M in research payments for this study in 2025 (543 payments).

Products named: Rinvoq

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Integrative Skin Science $150,264
  • First Oc Dermatolgy Research Inc $78,293
  • Uci Health-Orange, CA $70,374
  • Equity Medical LLC $65,997
  • Medical University South Carolina $61,087
  • Arlington Research Center Inc $59,523
  • Skin Care Research Inc $58,315
  • Gcm Medical Group Psc $52,245
  • Oregon Med Research Ctr PC $47,373
  • Dr Samuel Sanchez Psc $44,592
  • Lenus Research & Medical Group $42,250
  • Icahn School of Med at Mt Sinai $39,041
  • Caban Health LLC $38,561
  • Dermatologists of Sw Ohio LLC $37,740
  • Rlb MD PC $37,708
  • Total Skin & Beauty Dermatology Cen $37,633
  • Clinical Trials Research Institute $36,747
  • Johnson Dermatology Clinic $34,867
  • Regents of the Univ of Minnesota $34,357
  • Mindful Medical Research $31,793
  • Cleveland Clinic, OH $31,376
  • Northshore University Healthsystem - Evanston Hospital, IL $28,046
  • Remington-Davis Inc $27,712
  • Alliance Dermatology & Mohs Center $27,124
  • University of California Davis Medical Center, CA $23,302
  • Odrc Enterprises LLC $22,749
  • Henry Ford Health Hospital, MI $21,232
  • Michigan Center for Research $21,192
  • Metro Boston $20,313
  • Mountain West Derm-Blackhart PLLC $20,272
  • Physician Research $19,902
  • Marietta Dermatology Clinical $18,885
  • Dermatology Treatment And $18,492
  • Dermatology Research Associates Inc $18,370
  • The Administrators of the Tulane $18,017
  • Indiana University $17,061
  • Care Access Research LLC $15,635
  • Revival Research Corporation $14,504
  • Apex Clinical Trials LLC $13,452
  • Oliver Street 501 (a) Inc $13,315
  • Raven Clinical Research Inc $13,220
  • International Clinical Research $12,551
  • Cleaver Medical Group $11,906
  • The Skin Center Dermatology Group $11,570
  • Gsi Clinical Research LLC $11,072
  • Sadick Research Group LLC $10,911
  • The Board of Trustees of the Leland $10,519
  • UPMC $10,032
  • Center for Clinical Studies LTD LLP $9,982
  • Modern Research Associates PLLC $8,971
  • Clinical Research Puerto Rico Inc $8,504
  • Corazon USA LLC $8,402
  • Progressive Clinical Research PA $8,020
  • Dermatology and Skin Cancer $7,742
  • Lahey Clinic Inc $7,450
  • Bellaire Dermatology Associates $7,010
  • On-Site Clinical Solutions LLC $6,450
  • Avita Clinical Research LLC $6,361
  • International Clinical Research - $6,062
  • Clinical Research Institute Of $5,139
  • Skin Specialists PC $5,000
  • Cleaver Medical Group Dermatology $4,768
  • Southwest Skin Specialists LLC $3,597
  • Skin Care Research LLC $3,059
  • Florida Academic Centers $3,028
  • Complete Dermatology PLLC $3,000
  • Northwestern University $2,018
  • Probity Med Research Corporation $1,912
  • Medical University of South Carolina $1,529
  • Physicians Research Group II LLC $1,529
  • Physician Research Collaboration $1,529
  • Lenus Research $1,529
  • Oregon Dermatology and Research Center $1,529
  • Marietta Dermatology and the Skin Cancer Center $1,529
  • Total Skin and Beauty Dermatology Center $1,529
  • Raven Clinical Research $1,529
  • Skin Specialist PC $1,529
  • Clinical Research Institute of Michigan LLC $1,529
  • Johnson Dermatology $1,529
  • University of Pittsburgh Physician $1,529
  • Oliver Street Derma Holdings LLC $1,529
  • Mount Sinai School of Medicine $1,529
  • San Juan Med $1,529
  • University of Minnesota Regents $1,529
  • Remintondavis Inc $1,529
  • Florida Academic Dermatology Center $1,529
  • Michigan Center for Research Corporation $1,529
  • Tulane University School of Medicine Office of Academic Affairs $1,529
  • Dermatology Treatment and Research Center $1,529
  • Oregon Medical Research Center $1,529
  • Bellaire Dermatology $1,529
  • Complete Dermatology Inc $1,529
  • Equity Medical $1,529
  • Alliance Dermatology and Mohs Center $1,529
  • Caban Skin Institute $1,529
  • Clinical Research Puerto Rico $1,529
  • Sadick Dermatology Research Group $1,529
  • Dermatologists of Greater Columbus $1,529
  • Mountain West Derm Blackhart PLLC $1,529
  • Integrative Skin Science and Research $1,529

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.