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A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

Completed · Phase 3 · NCT06045221

Conditions: Type 2 Diabetes

At a glance

Research payments reported, 2025
$3.3M
U.S. investigators named
80
Sites paid
75
Planned or actual enrollment
1,698

About the trial

Sponsor
Eli Lilly and Company
Tested
Orforglipron (drug), Semaglutide (drug)
Dates
Started 2023-09-22; completion 2025-08-22
Results posted
Yes

The main purpose of this study is to assess efficacy and safety of orforglipron compared with oral semaglutide in participants with Type 2 diabetes and inadequate glycemic control with metformin.The study will last around 61 weeks.

From ClinicalTrials.gov, last updated 2026-09-15. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $3.3M in research payments for this study in 2025 (155 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Miami Dade Medical Research Institute LLC $168,833
  • Mgcendo LLC $126,310
  • San Fernando Valley Health Institute LLC $123,882
  • American Health Network of in LLC $115,221
  • Tri State Medical Group Inc $115,171
  • Yshay Shlesinger MD $114,899
  • Encompass Clinical Research $108,004
  • Velocity Clinical Research Inc $106,582
  • Texas Valley Clinical Research LLC $106,189
  • Infinity Clinical Research $104,527
  • Lucas Research Inc $94,365
  • Corvallis Clinic PC $89,647
  • Kansas City Research Institute $88,351
  • Cr Services Acquisition US LLC $84,702
  • Biopharma Informatic Inc Research Center $78,843
  • Fisher Scientific Co LLC $74,980
  • Eastside Research Associates LLC $74,329
  • Family First Medical Center $73,387
  • Optumcare Clinical Trials LLC $64,485
  • Clinical Research of West Florida Inc $61,555
  • Forty Third Medical Associates $61,496
  • Latin Clinical Trial Center Inc $60,808
  • Tekton Research Inc $54,877
  • Elligo Health Research Inc $51,292
  • Diabetes and Thyroid Center $50,093
  • Rainier Clinical Research Center $49,181
  • Alliance for Multispecialty Research Lls $47,226
  • South Florida Wellness and Clinical Resear $43,658
  • Total Medical Care $43,168
  • Latin Clinical Trial Center Florida $42,057
  • Southern Endocrinology Associates PA $41,401
  • Valley Clinical Trials Inc $40,898
  • Sky Clinical Research Network Group $39,894
  • Northwest Clinical Trials Inc $39,108
  • North Georgia Clinical Research $38,471
  • The Research Center of the Upstate $38,163
  • West Orange Endocrinology PA $37,992
  • Metabolic Research Institute Inc $37,374
  • Wr-Crcn LLC $34,888
  • Premier Research Inc $33,251
  • Research and Cardiovascular $30,997
  • Juno Research LLC $30,250
  • Pharmquest Life Sciences LLC $29,328
  • Revival Research Institute LLC $28,151
  • Neighborhood Healthcare $27,315
  • Preferred Primary Care Physicians Inc $26,499
  • Endocrine Ips PLLC $26,344
  • University Clinical Investigators Inc $26,251
  • Clinical Neuroscience Solutions DBA Cns Hlthcare $23,396
  • Logan Health Medical Center, MT $23,224
  • Piedmont Medical Research Associates Inc $18,524
  • Albany Medical College $14,381
  • New Phase Research & Development LLC $14,204
  • Clinical Research Atlanta $13,784
  • New West Physicians Inc $13,719
  • Delricht LLC $12,986
  • Wake Forest University Health Sciences $12,756
  • Cotton Oneil Msd of Stormont Vail Healthcare $10,431
  • Biopharma Informatic Inc $10,129
  • Great Lakes Medical Research LLC $6,894
  • Intend Research LLC $2,582
  • Cleveland Clinic, OH $2,514
  • Diabetes and Endocrinology Consultants $1,768
  • $1,712
  • Mehrdad Kevin Ariani MD $1,476
  • Columbus Clinical Research Inc $1,372
  • Advanced Medical Research Inc $1,135
  • Andrew J Lewin Med DBA National Rsrch Institute $977
  • Radiant Research Inc $969
  • Connecticut Clinical Research Institute LLC $942
  • Pharmquest LLC $749
  • Rheumatology Center of Houston $465
  • Cedars-Sinai Medical Center, CA $242
  • Hospital Metropolitano $195
  • Rainier Clinical Research Center Inc $165
  • Dallas Diabetes and Endo Research Center PA $105

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.