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A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults

Active, not recruiting · Phase 3 · NCT06047444

Conditions: Chronic Migraine

At a glance

Research payments reported, 2025
$3.3M
U.S. investigators named
69
Sites paid
90
Planned or actual enrollment
759

About the trial

Sponsor
Ipsen
Tested
Botulinum toxin type A (biological), Botulinum toxin type A (biological), Placebo (other), Botulinum toxin type A (biological), Botulinum toxin type A (biological)
Dates
Started 2023-10-12; completion 2026-11-12
Results posted
Not yet

The purpose of this study is to understand the safety and effectiveness of the study drug, Dysport® when compared with placebo in preventing chronic migraine. A migraine is a headache with severe throbbing pain or a pulsating sensation, usually on one side of the head, and is often accompanied by feeling or being sick and a sensitivity to bright lights and sound. Chronic migraine is defined as having at least 15 days of headache a month with at least 8 of those days being migraine headache days. Migraines are caused by a series of events which cause the brain to get stimulated/activated, which results in the release of chemicals that cause pain. Dysport® is a formulation of Botulinum toxi…

From ClinicalTrials.gov, last updated 2026-09-04. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Ipsen Innovation reported $3.3M in research payments for this study in 2025 (3,581 payments).

Products named: Dysport

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Alliance Clinical Network $701,757
  • Ki Health PArtners, Llc $362,310
  • Frontier Clinical Research, Llc $115,526
  • Axiom Research, Llc $115,304
  • Qcare Site Services Inc $115,176
  • Clinical Neuroscience Solutions, Inc $106,746
  • Helios Clinical Research $99,724
  • Accel Research Sites $94,762
  • Aga Clinical Trials $93,956
  • Quantum Clinical Trials $83,772
  • Neurology Center of New England, PC $76,326
  • J Lewis Research, Inc $74,484
  • Metrodora Institute $66,377
  • M3 Wake Research $66,240
  • Orthoneuro $63,050
  • Community Neuroscience Services $60,960
  • University of South Florida Health $59,223
  • Minneapolis Clinic of Neurology, Ltd $56,080
  • Flourish Research $53,483
  • Cedar Crosse Research Center $51,828
  • Neurology Clinic, PC $51,359
  • Neurology Center of North Orange County $47,283
  • Conquest Research, Llc $38,094
  • Thomas Jefferson University $37,116
  • Headache Center of Hope $31,480
  • Velocity Clinical Research $30,698
  • Central Alabama Research $30,236
  • Boston Clinical Trials and Medical Research, Inc $28,926
  • University of Colorado School of Medicine $27,817
  • $26,139
  • Neurology Center of New England $23,667
  • Indiana University Health, IN $22,987
  • Center for Neurological Disorders Bcn Research, Llc $21,980
  • Clinical Trial Network, Llc $20,578
  • Neostart Corporation $20,498
  • Research Your Health $19,971
  • Cognitive Clinical Trials $19,598
  • Zenos Clinical Research $18,998
  • Coastal Carolina Research Center $17,571
  • Honor Health John C. Lincoln Medical Center, AZ $16,675
  • Yale Univ $16,370
  • Board of Trustees of the Leland Stanford $15,764
  • Texas Neurology $15,586
  • Chicago Headache Center and Research Institute $15,418
  • Visionary Investigators Network $14,184
  • Las Vegas Medical Research Center $13,115
  • Conquest Research LLC $12,845
  • Inova Loudoun Hospital, VA $12,064
  • Sds Clinical Trials $12,030
  • Cenexel Iresearch Atlanta $9,750
  • Quest Research Institute $9,613
  • Thomas Jefferson University Research and Development $8,672
  • Clinical Research Professionals $8,385
  • Rochester Clinical Research $7,749
  • Medstar Health Research Institute $7,278
  • University of Miami School of Medicine $6,979
  • Alliance Clinical West Hills $6,330
  • Infinity Clinical Research $5,205
  • Spri Clinical Trials of Brooklyn $4,382
  • New England Institute for Neurology and Headache $4,260
  • Lone Star Neurology $3,990
  • Clinical Research Center of Nevada $3,180
  • Dent Neurosciences Research Center $3,150
  • Cct Research PApillion Research Center $3,120
  • Yale University School of Medicine $3,120
  • The Board of Trustees of the Leland Stanford Junior University $2,884
  • Guardian Angel Research Center $2,487
  • Fullerton Neurology and Headache Center $2,450
  • Kca Neurology $2,410
  • Nuvance Health $2,319
  • Healthpoint Health and Wellness $2,170
  • Duke University $2,000
  • Medstar Georgetown University Hospital Department of Neurology $1,968
  • Neuroscience Group $1,789
  • Usf Carol and Frank Morsani Center for Advanced Healthcare $1,710
  • New England Regional Headache Center, Inc $1,608
  • Iu Health Neurology Fort Wayne $1,590
  • Clinical Research Solutions $1,560
  • Alliance for Multispecialty Research $1,500
  • Bnl Health, Inc $1,260
  • Hasbani Neurology $1,260
  • Beth Israel Deaconess Medical Center $1,260
  • Velocity Clinical Research Hallandale Beach $1,170
  • Stanford University Medical Center $1,170
  • Cns Healthcare $1,170
  • Comprehensive Neurology Services, PA $848
  • University of Miami Dermatology $330
  • Wake Research Associates $315
  • Beth Israel Deaconess Medical Center, MA $143
  • Usf Health Byrd Alzheimers Institute $90

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.