A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of UCB0022 in Study Participants With Advanced Parkinson's Disease
Completed · Phase 2 · NCT06055985
Conditions: Parkinson Disease
At a glance
- Research payments reported, 2025
- $2.4M
- U.S. investigators named
- 65
- Sites paid
- 64
- Planned or actual enrollment
- 207
About the trial
- Sponsor
- UCB Biopharma SRL
- Tested
- Placebo (other), UCB0022 (drug)
- Dates
- Started 2023-11-17; completion 2025-04-11
- Results posted
- Not yet
The primary purpose of this study is to demonstrate the superiority of UCB0022 as an adjunctive treatment to stable dose of standard-of-care (SoC) (including at least levodopa therapy) over placebo with regard to motor fluctuations time spent in the OFF state (OFF time) in study participants with advanced Parkinson's Disease (PD).
From ClinicalTrials.gov, last updated 2026-04-06. Full record, eligibility and contacts (opens in a new tab)
Industry funding
UCB SA reported $2.4M in research payments for this study in 2025 (68 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Rohit Dhall, MD Neurology · Phoenix, AZ
- Stephen S. Flitman, M.D. Neurology · Phoenix, AZ
- Nida K. Laurin, M.D. Neurology · Scottsdale, AZ
- Perminder Bhatia, MD Neurology · Fresno, CA
- Khashayar Dashtipour, M.D. Neurology · Loma Linda, CA
- Danielle M. Feigenbaum, M.D. Neurology · Los Angeles, CA
- M. L. Purino, M.D. Neurology · Arcadia, CA
- Daniel D. Truong, M.D. Neurology · Fountain Valley, CA
- Rajeev Kumar, MD Neurology · Englewood, CO
- Amar Patel, M.D. Neurology · New Haven, CT
- Justin P. Martello, M.D. Neurology · Newark, DE
- Adalberto Aguilera, MD General Practice · Orlando, FL
- Emelina A. Arocha, M.D. Psychiatry · Miami, FL
- Alicia V. Cabrera, MD Neurology · Altamonte Springs, FL
- Raul E. Carballosa, M.D. Neurology · Boca Raton, FL
- Ramses Fernandez Melo, MD Neurology · Fort Myers, FL
- Eric M. Folkens, MD Family Medicine · Bradenton, FL
- Rekha Gandhi, MD Neurology · Winter Park, FL
- John M. Hill, MD Family Medicine · Deland, FL
- Stuart H. Isaacson, MD Neurology · Boca Raton, FL
- Israt Jahan Neurology · Tampa, FL
- William A. Justiz, MD Neurology · Naples, FL
- Andrew M. Lerman, M.D. Neurology · Miami, FL
- Juvenal E. Martinez, MD Family Medicine · Miami, FL
- Anette Nieves, MD Neurology · Ocala, FL
- Julie B. Schwartzbard, MD Neurology · Aventura, FL
- Stuart J. Shafer, MD Neurology · Vero Beach, FL
- Susan J. Steen, M.D. Neurology · Tampa, FL
- John C. Morgan, MD Neurology · Augusta, GA
- Marshall L. Nash, M.D. Neurology · Decatur, GA
- Nandakumar Narayanan, M.D. Neurology · Iowa City, IA
- Kristi K. George, MD Neurology · Indianapolis, IN
- Rajesh Pahwa, M.D. Neurology · Kansas City, KS
- Peter Hedera, MD Neurology · Louisville, KY
- John T. Slevin, MD Neurology · Lexington, KY
- Samuel A. Frank, M.D. Neurology · Boston, MA
- Marie-helene Saint-hilaire, M.D. Neurology · Boston, MA
- John L. Goudreau, D.O. Neurology · East Lansing, MI
- Shana S. Krstevska, M.D. Neurology · Troy, MI
- Danette C. Taylor, D.O. Neurology · Grand Rapids, MI
- Kara J. Wyant, MD Neurology · Ann Arbor, MI
- Bradley J. Robottom, MD Neurology · Durham, NC
- Odinachi N. Oguh, M.D Neurology · Las Vegas, NV
- Harini Sarva, M.D. Neurology · New York, NY
- Winona Tse, M.D. Neurology · New York, NY
- Lawrence W. Elmer, M.D. Neurology · Toledo, OH
- Megan L. Mackenzie, D.O. Neurology · Centerville, OH
- Ariane Park, M.D. Neurology · Gahanna, OH
- Umar A. Shuaib, MD Neurology · Cleveland, OH
- Joel Vandersluis, M.D. Neurology · Dayton, OH
- Kevin J. Klos, MD Neurosurgery · Tulsa, OK
- Howard Mandell, M.D. Neurology · Rock Hill, SC
- Thomas L. Davis, M.D. Neurology · Nashville, TN
- Aashoo P. Mentreddi, M.D. Neurology · Dallas, TX
- Elizabeth L. Peckham, D.O. Neurology · Round Rock, TX
- Eleni O. Vaou, M.D. Neurology · San Antonio, TX
- Paolo M. Moretti, MD Neurology · Salt Lake City, UT
- Leslie J. Cloud, MD Neurology · Richmond, VA
- Renzo Figari Jordan, M.D. Neurology · Charlottesville, VA
- Karen M. Thomas, DO Neurology · Virginia Beach, VA
- Jason L. Aldred, M.D. Neurology · Spokane, WA
- Arun Arora, M.D. Psychiatry · Bellevue, WA
- Jill K. Baird, M.D. Neurology · Vancouver, WA
- Daniel J. Burdick, MD Neurology · Kirkland, WA
- Barry K. Vaught, M.D. Neurology · Crab Orchard, WV
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Med-Care Research Corp $200,977
- Northwest Clinical Research Center $166,920
- Imaging Endpoints II LLC $122,628
- Hillcrest Medical Research, Llc $107,268
- Michigan State Univeristy $103,289
- Cleveland Clinic, OH $99,631
- University of Michigan Health System, MI $94,587
- Weill Medical College of Cornell University $90,924
- Premier Clinical Research Institute Inc $88,177
- Loma Linda University Health $73,943
- Visionary Investigators Network $72,656
- University of Utah Hospital and Clinics, UT $69,584
- University of Toledo $67,804
- First Excellent Research Group LLC $65,619
- The Medici Medical Research $64,327
- Ghsu Research Institute, Inc. $62,264
- Bradenton Research Center Inc $59,111
- Theia Clinical Research LLC $55,455
- Renstar LLC $54,010
- University of Texas Health Science Center at San Antonio $50,812
- Parkinsons Dis and Movement Disorder Institute Inc $44,512
- St. Joseph Mercy Oakland dba Saint Joseph Mercy,health System $44,141
- Virginia Commonwealth University $33,372
- Josephson Wallack Munshower Neurology P.c $28,275
- Velocity Clinical Research $25,547
- West Haven VA Medical Center $24,999
- The Ohio State University $24,763
- University of Southern California $24,420
- Vanderbilt University Medical Center, TN $22,546
- Pediatric Neurology PA $21,153
- Neurology of Central Florida $19,962
- University of Iowa Hospital & Clinics, IA $18,743
- Neuro PAin Medical Center Inc $18,220
- Legacy Emanuel Medical Center, OR $17,495
- Mayo Clinic Arizona $16,808
- Board of the Leland Stanford $13,400
- Anchor Medical Research, Llc $13,323
- Inland Northwest Research LLC $12,445
- Neurology Consultants of Dallas, PA $12,300
- Beth Israel Deaconess Medical Center West Campus $11,759
- Elligo Health Research Inc $10,729
- Central Texas Neurology $9,918
- Djl Clinical Research PLLC $9,325
- University of Virginia Medical Center, VA $9,200
- Cenexel Rocky Mountain $9,108
- Axiom Brain Health $9,051
- University of Kentucky Research Foundation $8,551
- Ku Infectious Disease $8,370
- Sentara Norfolk General Hospital, VA $8,050
- Boston Medical Center, MA $7,552
- Neurology Diagnostics, Inc $7,085
- Beth Israel Deaconess Medical Center, MA $6,850
- Christiana Hospital, DE $6,550
- Aqualane Clinical Research LLC $5,962
- Sandhill Research LLC $5,750
- The Movement Disorder Clinic of Oklahoma PLLC $5,500
- University of Arkansas Medical Sciences, AR $5,018
- Conquest Research, Llc $4,900
- Xenoscience Inc $4,326
- Parkinson's Disease and Movement Disorders Center of Boca Raton $4,300
- Geodyssey Research, Llc $4,300
- University of Louisville Research Foundation Inc $4,000
- Michigan Center of Medical Research $1,200
- Dayton Center for Neurological Disorders $380
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.