A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Recruiting · Phase 3 · NCT06064877
Conditions: Metastatic Head-and-neck Squamous-cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
At a glance
- Research payments reported, 2025
- $2.8M
- U.S. investigators named
- 27
- Sites paid
- 27
- Planned or actual enrollment
- 410
About the trial
- Sponsor
- AVEO Pharmaceuticals, Inc.
- Tested
- Ficlatuzumab (biological), Cetuximab (biological), Placebo (other)
- Dates
- Started 2024-01-11; completion 2027-11
- Results posted
- Not yet
The purpose of this study is to compare the efficacy and safety of ficlatuzumab plus cetuximab compared to placebo plus cetuximab in participants with recurrent/metastatic (R/M) HPV-negative Head and Neck Cancer. The primary hypothesis is that ficlatuzumab combined with cetuximab is superior to cetuximab alone in terms of progression-free survival and/or overall survival.
From ClinicalTrials.gov, last updated 2026-04-09. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Aveo Pharmaceuticals, Inc. reported $2.8M in research payments for this study in 2025 (259 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Ricklie A. Julian, M.D. Hematology & Oncology · Tucson, AZ
- Jiaxin Niu, MD Hematology & Oncology · Gilbert, AZ
- Deborah J. Wong, M.D., PH.D. Hematology & Oncology · Los Angeles, CA
- Aarti K. Bhatia, M.B.B.S. Medical Oncology · New Haven, CT
- Julie E. Bauman, M.D. MPH Hematology & Oncology · Washington, DC
- Christine H. Chung, MD Medical Oncology · Tampa, FL
- Tarek M. Mekhail, M.D. Hematology & Oncology · Orlando, FL
- Nabil F. Saba, M.D. Medical Oncology · Atlanta, GA
- Lawrence E. Feldman Hematology & Oncology · Chicago, IL
- Prakash Neupane, M.D. Hematology & Oncology · Westwood, KS
- Victor T. Lin, MD, PHD Hematology & Oncology · Baton Rouge, LA
- Enrico Castellucci Student in an Organized Health Care Education/Training Program · Boston, MA
- Robert I. Haddad, MD Medical Oncology · Boston, MA
- Ranee Mehra, M.D. Medical Oncology · Baltimore, MD
- Dan P. Zandberg, MD Hematology & Oncology · Baltimore, MD
- Vatche Tchekmedyian, M.D. Medical Oncology · South Portland, ME
- Douglas R. Adkins, MD Medical Oncology · Saint Louis, MO
- Nagashree Seetharamu, MD Internal Medicine · New Hyde Park, NY
- Marcelo R. Bonomi, MD Medical Oncology · Columbus, OH
- Jessica R. Bauman, M.D. Medical Oncology · Philadelphia, PA
- Christopher Lemmon, M.D. Hematology & Oncology · Pittsburgh, PA
- John M. Kaczmar, MD Medical Oncology · Charleston, SC
- Neal S. Akhave, MD Hematology & Oncology · Houston, TX
- Julio A. Peguero, M.D Medical Oncology · Corpus Christi, TX
- Ameen A. Salahudeen, M.D. Hematology · Dallas, TX
- Erin R. Alesi, MD Hematology & Oncology · Richmond, VA
- Stuart Wong, MD Medical Oncology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Ut MD Anderson Cancer Center $482,005
- Dana Farber Cancer Institute $370,835
- Institute for Cancer Research $260,951
- Banner Casa Grande Medical Center $196,127
- Emory University Hospital, GA $166,365
- University of Kansas Medical Center Research Institute Inc $151,796
- Moffitt Cancer Center $122,616
- Ronald Reagan UCLA Medical Center, CA $118,596
- University of Arizona $106,795
- Ohio State University $93,670
- Mary Bird Perkins Cancer Center $92,024
- Adventhealth Orlando, FL $87,546
- Virginia Commonwealth University School of Medicine $76,729
- Oncology Consultants PA $75,793
- Unv of Pittsburgh Cancer Institute $70,744
- Medical University of South Carolina $44,221
- The Feinstein Institute for Medical Research $40,202
- State of Maryland $38,545
- University of Cincinnati $36,763
- Biomedical Research Alliance of New York LLC $34,974
- Yale University School of Medicine $30,304
- Chicago Association of Research and Education in Science $30,000
- University of Illinois Hospital and Clinics, IL $28,266
- The George Washington University Medical Center $27,837
- Washington University $20,142
- The Medical College of Wisconsin $15,743
- Mainehealth Maine Medical Center, ME $3,035
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.