Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)
Active, not recruiting · Phase 3 · NCT06073821
Conditions: CLL
At a glance
- Research payments reported, 2025
- $26.0M
- U.S. investigators named
- 44
- Sites paid
- 58
- Planned or actual enrollment
- 652
About the trial
- Sponsor
- BeOne Medicines
- Tested
- Sonrotoclax (drug), Zanubrutinib (drug), Venetoclax (drug), Obinutuzumab (drug)
- Dates
- Started 2023-11-11; completion 2032-12
- Results posted
- Not yet
The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL)
From ClinicalTrials.gov, last updated 2026-10-14. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Beigene, Ltd. reported $26.0M in research payments for this study in 2025 (895 payments).
Products named: Brukinsa
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Steven Y. Liu, M.D. Hematology & Oncology · Anchorage, AK
- David Berz, MD, PHD, MPH Hematology & Oncology · Los Angeles, CA
- Gigi Q. Chen, M.D. Hematology & Oncology · Pleasant Hill, CA
- Catherine C. Coombs, M.D. Hematology & Oncology · Orange, CA
- Herbert A. Eradat, M.D., M.S. Internal Medicine · Los Angeles, CA
- Bita Fakhri, M.D., M.P.H Hematology · Palo Alto, CA
- Benjamin M. Heyman, M.D. Hematology · Irvine, CA
- Tanya Siddiqi, M.D. Hematology · Duarte, CA
- Manali K. Kamdar, MD Hematology & Oncology · Aurora, CO
- Scott F. Huntington, M.D. Hematology & Oncology · New Haven, CT
- Joseph L. Roswarski, M.D. Hematology & Oncology · Washington, DC
- Jacqueline Barrientos, M.D. Hematology & Oncology · Miami Beach, FL
- Yumeng Zhang Hematology & Oncology · Tampa, FL
- Andrew W. Pippas, MD Medical Oncology · Columbus, GA
- Sabarish R. Ayyappan, MD Hematology · Iowa City, IA
- Tara M. Graff, DO Medical Oncology · Clive, IA
- Eric Y. Mou, MD Hematology · Iowa City, IA
- Paul A. Fishkin, MD Hematology & Oncology · Peoria, IL
- Shuo Ma, M.D., PH.D. Hematology & Oncology · Chicago, IL
- Sunil Babu, M.D. Medical Oncology · Fort Wayne, IN
- Marc S. Hoffmann, MD Hematology & Oncology · Overland Park, KS
- Don A. Stevens, M.D. Medical Oncology · Louisville, KY
- Carter T. Davis, MD Hematology & Oncology · New Orleans, LA
- Sanjal H. Desai, M.D. Hematology · Minneapolis, MN
- Brad S. Kahl, MD Medical Oncology · Saint Louis, MO
- Danielle M. Brander, M.D. Hematology & Oncology · Durham, NC
- Ryan W. Jacobs, MD Hematology · Charlotte, NC
- Lori A. Leslie, M.D. Medical Oncology · Hackensack, NJ
- Paul M. Barr, MD Hematology · Rochester, NY
- James D'olimpio Hematology & Oncology · Lake Success, NY
- Catherine S. Diefenbach, M.D. Hematology & Oncology · New York, NY
- Nicole Lamanna, MD Medical Oncology · New York, NY
- Joanna M. Rhodes, MD, MSCE Medical Oncology · New Hyde Park, NY
- Seema A. Bhat, MD Hematology · Columbus, OH
- Allison M. Winter, M.D. Hematology & Oncology · Cleveland, OH
- Jeff P. Sharman, M.D. Medical Oncology · Eugene, OR
- Shazia K. Nakhoda, M.D. Hematology & Oncology · Philadelphia, PA
- Adelba Torres-lopez, M.D. Hematology & Oncology · San Juan, PR
- Bertrand M. Anz III, M.D. Hematology & Oncology · Chattanooga, TN
- Daniel A. Ermann, MD Hematology · Salt Lake City, UT
- Deborah M. Stephens, D.O. Hematology · Salt Lake City, UT
- Mazyar Shadman, MD,MPH Hematology & Oncology · Seattle, WA
- Guru Subramanian Guru Murthy, M.D Hematology & Oncology · Milwaukee, WI
- Benjamin M. Parsons, D.O. Hematology & Oncology · La Crosse, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- The Medical College of Wisconsin, Inc. $3.4M
- Washington University School of Medicine Siteman Cancer Center $1.9M
- The Board of Trustees of the Leland Stanford Junior University $1.8M
- Cleveland Clinic, OH $1.5M
- The University of Kansas Cancer Center $1.5M
- Fred Hutchinson Cancer Center $1.0M
- Duke University , $1.0M
- City of Hope National Medical Ctr $998,059
- University of Utah Hospital and Clinics, UT $889,418
- Fox Chase Cancer Center $775,961
- University of North Carolina at Chapel Hill - Lineberger Comprehensive Cancer Center $697,354
- Regents of the University of Minnesota $657,519
- University of Washington Medical Ctr, WA $637,878
- University of Colorado Cancer Center $613,665
- Wake Forest University Health Sciences $590,550
- Huntsman Cancer Institute $581,640
- Gundersen Lutheran Medical Foundation, Inc. $537,095
- Ochsner Medical Center Acute, LA $523,864
- Fred Hutchinson Cancer Research Center $518,760
- Norton Cancer Inst-Pav $483,044
- Ronald Reagan UCLA Medical Center, CA $462,943
- Uci Health-Orange, CA $416,112
- James Cancer Hospital and Solove Research Institute $377,280
- Scri Tennessee Oncology Chattanooga $314,400
- The Ohio State University Dba: Comprehensive Canc $261,487
- Auxilio Mutuo Hospital, PR $255,728
- Medstar Georgetown University Hospital $248,929
- Clinical Research Alliance, Inc. $235,559
- University of California San Diego (ucsd) - Moores Cancer Center $227,813
- Northwestern University $226,646
- Southeastern Regional Medical Center $202,078
- Oncology Associates of Oregon - Willamette Valley Cancer Center $197,088
- Norton Healthcare, Inc. $184,001
- Valkyrie Clinical Trials, Inc $167,434
- Alaska Oncology and Hematology, LLC $162,352
- Mission Cancer and Blood $157,200
- Rutgers, the State University $154,857
- Hackensack University Medical Center, NJ $151,930
- The Medical College of Wisconsin $119,802
- Fort Wayne Medical Oncology and Hematology $110,040
- Illinois Cancercare $103,110
- Rutgers the State University of New Jersey $94,320
- University of California - San Diego, Moores Cancer Center $87,269
- University of Iowa Hospital & Clinics, IA $77,680
- Southeastern Regional Medical Center, LLC $55,480
- Strong Memorial Hospital, NY $55,477
- Columbia University Medical Center $47,160
- Georgetown University Medical Center $43,938
- Columbus Regional Research Institute, LLC D/b/a Centricity Research $40,055
- Yale University $38,606
- NYU Grossman School of Medicine $29,870
- University of Colorado $14,314
- Mount Sinai Medical Center of Florida, Inc, FL $8,106
- John Muir Medical Center - Walnut Creek Campus, CA $2,500
- Moffitt Cancer Center $2,448
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.