A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction
Recruiting · Phase 3 · NCT06082037
Conditions: Lung Transplant Rejection
At a glance
- Research payments reported, 2025
- $1.5M
- U.S. investigators named
- 30
- Sites paid
- 34
- Planned or actual enrollment
- 180
About the trial
- Sponsor
- Sanofi (with Meiji Seika Pharma Co., Ltd.)
- Tested
- Belumosudil (drug), Azithromycin (drug), Placebo (drug)
- Dates
- Started 2023-10-10; completion 2030-10-01
- Results posted
- Not yet
This double-blind, randomized, placebo-controlled, multinational, multicenter, parallel-group, Phase 3, 2-arm, study will investigate the efficacy and safety of belumosudil compared with placebo, both administered on top of azithromycin and standard-of-care regimen of immunosuppression in male or female participants at least 1 year after bilateral lung transplant, who are at least 18 years of age and who have evidence of progressive CLAD despite azithromycin therapy. Study details include: The study duration will be up to 31 weeks for participants not entering the open-label extension (OLE) period and up to 57 weeks for participants entering the OLE period but not the long-term OLE. The t…
From ClinicalTrials.gov, last updated 2026-10-28. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Sanofi US Services Inc. reported $1.5M in research payments for this study in 2025 (228 payments).
Products named: Rezurock
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Keith Wille Critical Care Medicine · Birmingham, AL
- Rajat Walia, MD Pulmonology · Phoenix, AZ
- Amit Banga, MD Pulmonology · Stanford, CA
- Stephen S. Weigt, MD Pulmonology · Los Angeles, CA
- Remzi Bag Pulmonology · Jacksonville, FL
- Andres Pelaez Freidel, M.D. Pulmonology · Miami, FL
- Martin R. Zamora, MD Critical Care Medicine · Orlando, FL
- Tahuanty A. Pena, MD, MS Pulmonology · Iowa City, IA
- Ambalavanan Arunachalam, M.D Pulmonology · Chicago, IL
- Emily S. Clausen, MD Pulmonology · Maywood, IL
- Daniel Dilling, MD Critical Care Medicine · Maywood, IL
- Puneet S. Garcha, M.D. Pulmonology · Silver Spring, MD
- Reda E. Girgis, MD Pulmonology · Grand Rapids, MI
- Shijing Jia, M.D. Pulmonology · Ann Arbor, MI
- Kapilkumar N. Patel, M.D. Critical Care Medicine · Winston Salem, NC
- Jamie L. Todd, MD Internal Medicine · Durham, NC
- Selim M. Arcasoy, M.D. Pulmonology · New York, NY
- Ali Mansour, MD Internal Medicine · Bronx, NY
- Darya Rudym, MD Pulmonology · New York, NY
- Purav C. Shah, M.D. Pulmonology · New York, NY
- Marie M. Budev, DO Pulmonology · Cleveland, OH
- Bronwyn L. Small, M.D. Pulmonology · Columbus, OH
- Andrew M. Courtwright, MD, PHD Pulmonology · Philadelphia, PA
- Anil J. Trindade, MD Pulmonology · Nashville, TN
- Todd Grazia, MD Pulmonology · Dallas, TX
- Vaidehi Kaza, M.D, M.P.H Critical Care Medicine · Dallas, TX
- Holly Keyt, MD Critical Care Medicine · San Antonio, TX
- Jihad G. Youssef, M.D. Pulmonology · Houston, TX
- Shambhu Aryal, MD Pulmonology · Falls Church, VA
- Michael H. Eberlein, MD Pulmonology · Madison, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Mercy General Hospital, CA $133,708
- Duke University Gsrb1 4th Fl $123,520
- Vanderbilt University Medical Center, TN $119,540
- Corewell Health Spectrum Health Hospitals $112,878
- Northwestern University $106,739
- Ronald Reagan UCLA Medical Center, CA $102,478
- Mayo Clinic Jacksonville Corp $100,170
- Hospital of Univ of Pennsylvania, PA $86,750
- Board of Trustees of the Leland $60,702
- University of Alabama Hospital, AL $50,350
- Inova Fairfax Hospital $47,091
- University of Iowa Hospital & Clinics, IA $44,324
- University of Michigan Health System, MI $42,056
- Cleveland Clinic, OH $40,590
- Baylor College of Medicine Texas Childrens Hospital Pediatric $37,655
- Baylor College of Medicine Anesthesiology $33,094
- Biomedical Research Alliance of New York LLC $27,240
- Emory University Hospital, GA $27,180
- Baylor Research Institute Bri $24,350
- The Trustees of Columbia University in The City of New York $22,936
- The Methodist Hospital Research Institute Houston Methodist Research Institute $22,178
- Loyola University Medical Center $16,463
- New York University NYU Grossman School of Medicine An Administrative Unit of New York University $15,628
- Adventhealth Orlando, FL $14,752
- University of Miami Office of Research Administration Ora $10,700
- The Ohio State Univ Found $9,900
- University of Texas at San Antonio $9,188
- University of South Florida $7,150
- University of Maryland Baltimore Attn Sponsored Programs Accounting $6,292
- The Board of Trustees of the Lealan Stanford Junior University Stanford University $6,184
- The Ohio State University $3,375
- University of Maryland Baltimore Foundation Inc $1,898
- University of Texas Southwestern $1,750
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.