Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation
Active, not recruiting · Not applicable · NCT06096337
Conditions: Persistent Atrial Fibrillation
At a glance
- Research payments reported, 2025
- $2.1M
- U.S. investigators named
- 46
- Sites paid
- 47
- Planned or actual enrollment
- 484
About the trial
- Sponsor
- Boston Scientific Corporation
- Tested
- FARAPULSE™ Pulsed Field Ablation (PFA) System (device), Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone (drug)
- Dates
- Started 2023-12-28; completion 2028-02-04
- Results posted
- Not yet
The purpose of this study is to establish the safety and effectiveness of pulsed field ablation as a first-line ablation treatment for subjects with persistent atrial fibrillation as compared to subjects who received an initial treatment with anti-arrhythmic drugs.
From ClinicalTrials.gov, last updated 2026-08-28. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Boston Scientific Corporation reported $2.1M in research payments for this study in 2025 (267 payments).
Products named: Clinical Trial Product
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Hugh Mcelderry Cardiac Electrophysiology · Birmingham, AL
- Devi G. Nair, MD Cardiac Electrophysiology · Jonesboro, AR
- Darren F. Peress, MD Cardiac Electrophysiology · Tucson, AZ
- Ashish Sadhu, M.D. Cardiac Electrophysiology · Scottsdale, AZ
- Eric F. Buch, M.D. Cardiac Electrophysiology · Los Angeles, CA
- Jonathan W. Dukes, M.D. Cardiac Electrophysiology · Ventura, CA
- Douglas N. Gibson, M.D, Cardiology · La Jolla, CA
- Alexander C. Perino, MD Cardiac Electrophysiology · Stanford, CA
- Wilber W. Su, MD Cardiology · Stanford, CA
- Venkata V. Bavikati, MBBS, MPH Cardiac Electrophysiology · Tallahassee, FL
- Robert E. Eckart, DO Cardiac Electrophysiology · Sarasota, FL
- Kevin J. Makati, MD Cardiology · Lutz, FL
- Shalin Shah, M.D. Cardiac Electrophysiology · Tampa, FL
- David B. Delurgio, M.D. Cardiac Electrophysiology · Atlanta, GA
- Paari Dominic, M.B.B.S. Cardiac Electrophysiology · Iowa City, IA
- Jason Meyers, MD Cardiac Electrophysiology · West Des Moines, IA
- Ziad F. Issa, M.D. Cardiac Electrophysiology · Springfield, IL
- Kevin M. Trulock, M.D. Cardiac Electrophysiology · Indianapolis, IN
- Gery F. Tomassoni, M.D. Cardiac Electrophysiology · Lexington, KY
- Nitesh Sood, MD Cardiac Electrophysiology · Fall River, MA
- Jonathan Chrispin, MD Cardiac Electrophysiology · Baltimore, MD
- Andre J. Gauri, M.D. Cardiac Electrophysiology · Grand Rapids, MI
- Hakan Oral, MD Cardiac Electrophysiology · Ann Arbor, MI
- Ammar M. Killu, MBBS Cardiology · Rochester, MN
- Jamie H. Kim, MD Cardiac Electrophysiology · Londonderry, NH
- Suneet Mittal, M.D. Cardiac Electrophysiology · Paramus, NJ
- Gunjan J. Shukla, MD Cardiac Electrophysiology · Hackensack, NJ
- Jim W. Cheung, MD Cardiac Electrophysiology · New York, NY
- Jason Chinitz, MD Student in an Organized Health Care Education/Training Program · New York, NY
- Chee H. Kim, MD Cardiology · Williamsville, NY
- Jorge E. Romero, M.D Cardiac Electrophysiology · Syracuse, NY
- Auroa Badin, M.D Cardiac Electrophysiology · Columbus, OH
- Gaurang D. Gandhi, MD FACC Cardiac Electrophysiology · Cincinnati, OH
- Ayman A. Hussein, M.D. Cardiac Electrophysiology · Cleveland, OH
- David A. Sandler, M.D. Cardiac Electrophysiology · Tulsa, OK
- Brian T. Schuler, MD Cardiac Electrophysiology · York, PA
- Todd N. Senn, MD Cardiac Electrophysiology · Columbia, SC
- Travis D. Richardson, M.D. Cardiac Electrophysiology · Nashville, TN
- Sean P. Whalen, M.D. Cardiac Electrophysiology · Nashville, TN
- Karan S. Bhalla, MD Cardiology · Pasadena, TX
- Andrea Natale, MD Cardiac Electrophysiology · Austin, TX
- Muhie Dean Sabayon, M.D. Cardiac Electrophysiology · Galveston, TX
- Stanislav Weiner, MD Cardiac Electrophysiology · Longview, TX
- Michael Cutler, DO Cardiac Electrophysiology · Murray, UT
- Guru P. Mohanty, M.D. Cardiac Electrophysiology · North Chesterfield, VA
- Jasbir S. Sra, MD Cardiac Electrophysiology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Nair Research LLC $466,993
- Ohiohealth Research Institute $227,763
- Intermountain Health Utah Valley Hospital, UT $99,705
- Johns Hopkins University $97,051
- Cardiology Associates Medical Group $67,646
- Corewell Health $66,401
- Trihealth Inc $66,219
- Emory University Hospital, GA $57,563
- Cleveland Clinic, OH $56,501
- Community Hospital East, IN $55,004
- Board of Trustees of the Leland Stanford Junior University $54,920
- Phoenix Cardiovascular Research Group $51,223
- Christus Trinity Mother Frances Health System $50,932
- Scripps Mercy Hospital, CA $46,091
- Biomedical Research Alliance of New York $40,608
- Wake Forest University Health Sciences $39,417
- Oklahoma Heart Research & Education Foundation $39,406
- University of Arizona $34,523
- Karan Bhalla MD PLLC $33,404
- Vanderbilt University Medical Center, TN $32,376
- HCA Research Institute LLC $31,120
- Baycare Health System Inc $31,005
- Wellspan Health $27,691
- Valley Hospital $27,350
- Hti Hospital Holdings Inc $25,447
- University of Michigan Health System, MI $25,107
- New York Medical College $24,930
- Weill Cornell Medical Center $22,469
- Mayo Clinic $22,135
- Mercyone Des Moines Medical Center, IA $21,364
- University of Alabama Hospital, AL $17,928
- Sarasota Memorial Hospital, FL $13,863
- Ronald Reagan UCLA Medical Center, CA $13,350
- Adventhealth Orlando, FL $12,782
- The Research Foundation for The State University of New York $12,019
- Tallahassee Research Institute Incorporated $8,619
- Southcoast Hospitals Group Inc $8,225
- Mayo Clinic Rochester $7,577
- Aurora Research Institute LLC $6,191
- Baptist Health Lexington, KY $3,533
- University of Iowa Hospital & Clinics, IA $3,239
- Catholic Medical Center $2,959
- Weill Medical College Of $2,542
- Texas Cardiac Arrhythmia Research Foundation $1,980
- Brigham and Women's Hospital, MA $1,958
- Pima Heart Physicians PC $1,522
- University of Texas Medical Branch Galveston, TX $1,124
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.