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A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo

Active, not recruiting · Phase 3 · NCT06118411

Conditions: Vitiligo

At a glance

Research payments reported, 2025
$2.3M
U.S. investigators named
50
Sites paid
72
Planned or actual enrollment
614

About the trial

Sponsor
AbbVie
Tested
Upadacitinib (drug), Placebo (drug), NB-UVB (narrow-band ultraviolet B) Phototherapy (other)
Dates
Started 2023-12-19; completion 2028-03
Results posted
Not yet

Vitiligo is a common chronic autoimmune disease that causes the body's immune system to attack its own pigment producing skin cells. This study is to evaluate how safe and effective upadacitinib is in participants with non-segmental vitiligo (NSV). Adverse effects and change in disease activity will be assessed. Upadacitinib is currently being investigated for the treatment of NSV. There will be 2 replicate studies running at the same time (Study 1 and Study 2 with periods A and B), an optional exploratory NB-UVB phototherapy study (Study 3), and a re-randomized dose-escalation study (Study 4). In Period A, participants are placed in 1 of 2 groups called treatment arms. Each group receive…

From ClinicalTrials.gov, last updated 2026-06-09. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $2.3M in research payments for this study in 2025 (469 payments).

Products named: Rinvoq

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Integrative Skin Science $320,500
  • T Joseph Raoof MD Inc $146,356
  • Direct Helpers Research Center $125,771
  • Denova Research $80,158
  • Icahn School of Med at Mt Sinai $73,453
  • Dermatology Treatment And $72,748
  • Caban Health LLC $72,450
  • Odrc Enterprises LLC $72,450
  • Skin Care Research Inc $70,209
  • Minnesota Clinical Study Center $67,261
  • Advanced Research Associates $62,837
  • Encore Medical Research of Weston $61,691
  • Marwah Investments Corporation $56,760
  • Clinical Trials Research Institute $53,222
  • Mindful Medical Research $51,367
  • Dawes Fretzin Clinical Research $49,087
  • Savin Medical Group LLC $48,318
  • Encore Medical Research LLC $42,126
  • Bellaire Dermatology Associates $41,831
  • Henry Ford Health Hospital, MI $41,312
  • Oakland Hills Dermatology PC $39,638
  • Dr Samuel Sanchez Psc $39,162
  • Iltefat Hamzavi $38,702
  • Progressive Clinical Research PA $37,511
  • Dermresearchcenter of New York Inc $32,353
  • University of Massachusetts $30,246
  • Pearl E Grimes $30,200
  • Corazon USA LLC $28,884
  • Oregon Med Research Ctr PC $27,971
  • Uci Health-Orange, CA $26,446
  • Michigan Center for Research $25,774
  • Tufts Medical Center, MA $25,657
  • Gsi Clinical Research LLC $25,595
  • Schweiger Dermatology PC $23,276
  • Alliance Dermatology & Mohs Center $18,396
  • Great Lakes Research Group Inc $16,574
  • Gcm Medical Group Psc $15,800
  • Clinohio Research Services LLC $12,929
  • Dermatology Research Associates Inc $11,211
  • Scb Research Center Corp $10,044
  • Fife Dermatology PC $9,609
  • Probity Medical Research Corp $9,512
  • Indiana University $8,915
  • Steven A Davis MD PA $8,806
  • Apex Clinical Trials LLC $8,140
  • Skin Care Research LLC $7,075
  • Cleaver Medical Group Dermatology $6,465
  • Florida Academic Centers $5,935
  • Caban Skin Institute $3,537
  • Oregon Medical Research Center $3,537
  • Michigan Center for Research Corporation $3,537
  • Interspond LLC $3,537
  • Savin Medical Practice LLC $3,537
  • Mindful Rheumatix $3,537
  • Arano LLC $3,537
  • Oregon Dermatology and Research Center $3,537
  • Pearl E Grimes MD $3,537
  • Oakland Hill Dermatology $3,537
  • Florida Academic Dermatology Center $3,537
  • Probity Med Research Corporation $3,537
  • University of Massachusetts School of Medicine $3,537
  • Alliance Dermatology and Mohs Center $3,537
  • Dermatology Treatment and Research Center $3,537
  • Derm Research Center of New York $3,537
  • Sbc Research Center $3,537
  • Bellaire Dermatology $3,537
  • Elligo Health Research Inc $3,537
  • Integrative Skin Science and Research $3,537
  • Mount Sinai School of Medicine $3,537
  • Cleaver Medical Group $2,358
  • Indiana University Health Center $1,179
  • University of California Davis Medical Center, CA $295

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.