A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis
Active, not recruiting · Phase 2 · NCT06136741
Conditions: Moderate to Severe Atopic Dermatitis
At a glance
- Research payments reported, 2025
- $1.1M
- U.S. investigators named
- 28
- Sites paid
- 27
- Planned or actual enrollment
- 396
About the trial
- Sponsor
- Nektar Therapeutics
- Tested
- Rezpegaldesleukin (drug), Placebo (drug)
- Dates
- Started 2023-11-15; completion 2026-12-31
- Results posted
- Not yet
This is an interventional, randomized, parallel group, treatment, Phase IIb, double blind, 4-arm study to assess the effect of pegylated-recombinant-human interleukin-2 (rezpegaldesleukin) in adult participants with moderate to severe atopic dermatitis. The estimated duration is 15-35 days for screening, an Induction Period of 16 weeks, a Maintenance Period from Week 16-Week 52, and a Posttreatment Follow-Up Period for an additional year up to approximately Week 104 for all patients. Patients with a response at Week 16 (end of induction therapy) will be re-randomized for the maintenance therapy period.
From ClinicalTrials.gov, last updated 2026-08-21. Full record, eligibility and contacts (opens in a new tab)
Industry funding
E.r. Squibb & Sons, L.l.c. reported $1.1M in research payments for this study in 2025 (29 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Dowling B. Stough IV, MD Dermatology · Hot Springs, AR
- Vivian Laquer, M.D. Dermatology · Irvine, CA
- Bruce Torkan, M.D. General Practice · Los Angeles, CA
- Paul S. Yamauchi, M.D., PHD Dermatology · Santa Monica, CA
- Idalia A. Acosta, M.D. General Practice · Miami, FL
- Miguel A. Aponte, M.D. General Practice · Miami Lakes, FL
- Eddie Armas, MD General Practice · South Miami, FL
- Wanda M. Boote, MD Dermatology · St Petersburg, FL
- Brian J. Feinstein, D.O. Dermatology · Delray Beach, FL
- Matthew B. Zook, MD, PHD Dermatology · St Petersburg, FL
- Megan B. Vissing, M.D. Dermatology · New Albany, IN
- Cindy E. Owen, M.D. Dermatology · Louisville, KY
- Erin E. Boh, MD PHD Dermatology · New Orleans, LA
- Suresh Anne, MD Allergy & Immunology · Flint, MI
- Brent M. Boyce, M.D. Dermatology · Sebewaing, MI
- Ali Moiin, MD Dermatology · Troy, MI
- Elliot Shin, MD Family Medicine · Las Vegas, NV
- Neil S. Sadick, M.D. Dermatology · New York, NY
- Jorge A. Garcia-zuazaga, M.D. Mohs Surgery · Concord Township, OH
- Craig A. Rohan, MD Dermatology · Wright Patterson Afb, OH
- Christina L. Feser, D.O. Dermatology · Clarksville, TN
- Lauren S. Campbell, M.D. Dermatology · Cypress, TX
- Adelaide A. Hebert, M.D. Dermatology · Bellaire, TX
- Timothy Rodgers Dermatology · Frisco, TX
- Sarah I. Smiley, D.O. Hospitalist · Austin, TX
- Swapnil Vaidya, MD, PHD Allergy & Immunology · Fort Worth, TX
- Katherine B. Reed, M.D. Dermatology · Spokane, WA
- William P. Werschler, MD Dermatology · Spokane, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Sadick Dermatology Research Group $181,999
- Apex Clinical Research Center $130,278
- Encore Medical Research, Llc $92,945
- Onyx Clinical Research $82,002
- Well Pharma Med Research Corporation $65,167
- First Oc Dermatology $55,752
- Academic Alliance in Dermatology $50,006
- Global Clinical Professionals Research $45,685
- San Marcus Research Clinic, Inc $42,131
- Cypress Dermatology $39,496
- Premier Clinical Research $37,040
- Wright State Physicians, Inc $30,525
- La Universal Research Center $30,078
- University of Texas Health Science Center at Houston $27,845
- Dermatology Specialists Research $27,744
- Revival Research Institute, Inc $26,420
- 3sync Llc $22,235
- $20,768
- International Clinical Research $20,045
- Dermatoogy Trial Associates $19,655
- Clinical Science Institute $17,389
- Dermatology Specialists of Spokane $15,812
- Jubilee Clinical Research, Inc $10,943
- Great Lakes Research Group $8,751
- Velocity Clinical Research $7,003
- Tulane University Health Sciences Center $4,250
- Innovate Research Llc $1,750
- North Texas Center for Clinical Research $330
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.