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Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis

Active, not recruiting · Phase 3 · NCT06141473

Conditions: Multiple Sclerosis

At a glance

Research payments reported, 2025
$6.7M
U.S. investigators named
87
Sites paid
90
Planned or actual enrollment
1,655

About the trial

Sponsor
Sanofi
Tested
Frexalimab (drug), Teriflunomide (drug), Placebo infusion (drug), Placebo tablet (drug), MRI contrast-enhancing agents (drug), Cholestyramine (drug), Activated charcoal (drug)
Dates
Started 2023-12-13; completion 2027-05-06
Results posted
Not yet

The purpose of each study is to independently measure the annualized relapse rate (ARR) with administration of frexalimab compared to a daily oral dose of teriflunomide in male and female participants with relapsing forms of multiple sclerosis (aged 18 to 55 years at the time of enrollment). People diagnosed with relapsing forms of multiple sclerosis are eligible for enrollment as long as they meet all the inclusion criteria and none of the exclusion criteria. Study details include: * This event-driven study will have variable duration depending on the recruitment rate, the event rate, the study discontinuation rate and the 12-month minimum treatment duration. Different participants will …

From ClinicalTrials.gov, last updated 2026-07-20. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Genzyme Corporation reported $6.7M in research payments for this study in 2025 (696 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Neurology of Central Florida Research Center Llc $487,203
  • Alabama Neurology Associates PC $361,097
  • Regina Berkovich MD Phd $311,067
  • Orlando Health, FL $278,350
  • Cleveland Clinic, OH $265,773
  • Palm Beach Neurology Premiere Research Institute $255,505
  • 0000203566 North Central Neurology Assocs PC $243,894
  • Boster Research Center Llc $226,123
  • Velocity Clinical Research Inc $209,942
  • Norton Healthcare Inc $183,907
  • The Ohio State University Ccicmass Spectrometry and Proteomi Facility $180,683
  • North Texas Institute of Neurology Headache $169,903
  • Neurology Consultants of Dallas PA $162,914
  • Swedish Medical Center, WA $140,206
  • University of New Mexico $139,335
  • Chemidox Advance Clinical Trials Llc $125,487
  • University of South Florida $124,609
  • Piedmont Healthcare PA $117,851
  • Sibyl Wray MD Neurology PC $115,939
  • Sheth MD PA Lone Star Neurology of San Antonio $112,524
  • University of Alabama Hospital, AL $112,291
  • Profound Research Llc $106,647
  • Uci Health-Orange, CA $100,761
  • Imaging Endpoints II Llc $96,460
  • Glendale Neurological Associates PC $92,063
  • Delricht LLC $84,707
  • Infinite Research Group Llc $84,472
  • Mercy General Hospital, CA $81,648
  • Interspond LLC $78,209
  • Perseverance Research Center $77,089
  • The Ohio State University $76,699
  • Consultants in Neurology, Ltd $65,562
  • Renown Regional Medical Center, NV $63,346
  • New York University NYU Grossman School of Medicine An Administrative Unit of New York University $61,403
  • Abington Neurological Associates $61,340
  • Wheaton Franciscan Healthcare Southeast Wisconsin Inc $55,956
  • Physicians Group Lc Bjc Medical Group of Mo $53,462
  • Neurology Offices of South Florida $53,365
  • Anesc Research $51,188
  • Rutgers the State University of New Jersey $48,986
  • Sanford Research $48,962
  • Indiana University Health Inc Attn Char Schaffer $47,175
  • Beth Israel Deaconess Medical Center, MA $46,858
  • Investigator Research Network Llc $45,179
  • Biomedical Research Alliance of New York LLC $45,035
  • University of Kansas Medical Center Research Inst Inc $41,746
  • Medical College of Wisconsin Inc Att Department of Medicine Administrati Co Wendy Wozney Medical Col $41,622
  • Neurology Associates, PA $36,845
  • Regents of the University of Minnesota University of Minnesota Department of Pediatrics Mmc 391 Co B $36,092
  • Hoag Memorial Hospital Presbyterian $35,600
  • The Memorial Hospital Dba Memorial Healthcare $34,797
  • Pennsylvania State University Attn Tressa Jilek Controllers Office Mc G230 $34,339
  • Nova Clinical Research Bradenton $33,300
  • University of Texas at San Antonio $31,410
  • Saturn Research Solutions Llc $28,518
  • Georgetown University Office of Tech Commercialization $26,200
  • $25,620
  • Research By Design Llc $25,475
  • Baptist Health Lexington, KY $22,288
  • Multicare Good Samaritan Hospital, WA $22,150
  • Sentara Medical Group $20,711
  • Boston Clinical Trials Llc $19,431
  • Ohio Health Research Inst $18,005
  • Overland PArk Surgical Specialties LLC College PArk Family Care Center $17,945
  • Multiple Doctors $17,524
  • Savannah Neurology Specialists $17,500
  • Wake Forest University Health Science $17,308
  • Allegheny Health Network $16,800
  • Springfield PC $16,300
  • Heidi Crayton $15,730
  • Advanced Neurosciences Res LLC $14,764
  • Methodist Hospitals Inc, IN $14,495
  • Washington University $14,282
  • Oklahoma Medical Research Foundation $13,300
  • Baylor College of Medicine Anesthesiology $11,376
  • The University of Cincinnati Foundation $11,240
  • Rocky Mountain Ms Research Group LLC $10,900
  • Sharlin Health and Neurology $9,817
  • The Neurological Instit,pa $8,145
  • Mayo Clinic Jacksonville Corp $7,985
  • Midwest Immunology Clinics PLLC $6,984
  • Ochsner Medical Center Acute, LA $6,000
  • University of Iowa Hospital & Clinics, IA $5,750
  • Axiom Clinical Research of Florida $3,880
  • Thomas Jefferson University Attn Daisy Spruill $1,800
  • Axiom Brain Health Llc $1,325
  • Regents of the University of Colorado $1,263
  • Lake Huron Medical Center Op $1,195
  • Springfield Clinic LLP $375
  • International Neurorehabilitation Institute $80

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.