A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Recruiting · Phase 2 · NCT06143956
Conditions: Obesity, Overweight
At a glance
- Research payments reported, 2025
- $4.0M
- U.S. investigators named
- 53
- Sites paid
- 60
- Planned or actual enrollment
- 1,481
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- LY3305677 (drug), LY3841136 (drug), Tirzepatide (drug), LY3549492 (drug), LY3532226 (drug), Placebo (drug), Placebo (drug)
- Dates
- Started 2023-11-17; completion 2028-02
- Results posted
- Not yet
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.
From ClinicalTrials.gov, last updated 2026-10-07. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $4.0M in research payments for this study in 2025 (166 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Matthew W. Doust, MD Pain Medicine · Scottsdale, AZ
- Anita Kohli, MD Infectious Disease · Chandler, AZ
- Yessica R. Sachdeva, M.D. Internal Medicine · Mesa, AZ
- Mark P. Christiansen, MD Endocrinology & Diabetes · Walnut Creek, CA
- Linda M. Gaudiani, MD Endocrinology & Diabetes · Greenbrae, CA
- Stanley Hsia, M.D. Endocrinology & Diabetes · Los Angeles, CA
- Lawrence D. Sher, M.D. Pediatrics · Rolling Hills Estates, CA
- David M. Radin, MD Internal Medicine · Stamford, CT
- Cathy B. Barnes, MD Family Medicine · New Port Richey, FL
- Jose F. Cardona, M.D. General Practice · Miami, FL
- Lazaro R. Diaz-nunez, MD Family Medicine · Naples, FL
- Dunia Llapur Hernandez, MD Internal Medicine · Miami, FL
- Edgardo J. Riverarivera, MD Emergency Medicine · Leesburg, FL
- Senan Sultan, M.D. Endocrinology & Diabetes · Jacksonville, FL
- Alan Parsa, M.D. Endocrinology & Diabetes · Honolulu, HI
- Anuj Bhargava, MD Endocrinology & Diabetes · West Des Moines, IA
- Joseph R. Moore, M.D. Pediatrics · Ammon, ID
- Liana K. Billings, MD, MMSC Endocrinology & Diabetes · Skokie, IL
- Manish Jain, M.D. Rheumatology · Chicago, IL
- Susan R. Brian, MD Endocrinology & Diabetes · Topeka, KS
- Harold E. Bays, MD Endocrinology & Diabetes · Louisville, KY
- James P. Maynard, M.D. Neurology · Fort Thomas, KY
- Angela K. Fitch, MD Obesity Medicine · Boston, MA
- Jeffrey A. Norton, M.D. Pain Medicine · Lawrence, MA
- David J. Shih, MD Nephrology (Kidney) · North Dartmouth, MA
- Neil J. Fraser, MD Internal Medicine · Troy, MI
- David W. Strong, M.D., PH.D. Emergency Medicine · Detroit, MI
- Ralph J. Duda JR., M.D. Endocrinology & Diabetes · Springfield, MO
- Timothy R. Smith, M.D. Internal Medicine · Saint Peters, MO
- Rupal Trivedi, MD Family Medicine · Saint Louis, MO
- David G. True, D.O. Rheumatology · Nixa, MO
- Awawu E. Igbinadolor, M.D. Adolescent Medicine · Monroe, NC
- Kathryn J. Lucas, MD Endocrinology & Diabetes · Morehead City, NC
- Claire Presswood Internal Medicine · Morehead City, NC
- Cornell V. Calinescu, MD Emergency Medicine · Las Vegas, NV
- Barbara J. Connor, M.D. Obesity Medicine · Syracuse, NY
- Patrick M. Connors, M.D. Internal Medicine · Rochester, NY
- Robert C. Cupelo, M.D. Internal Medicine · East Syracuse, NY
- Laszlo L. Mechtler, MD Neurology · Amherst, NY
- Warren D. Spinner, D.O. Neurology · Port Jefferson Station, NY
- James D. Franklin III, M.D. Family Medicine · Greenville, SC
- Ronald K. Mayfield, M.D. Endocrinology & Diabetes · Spartanburg, SC
- Saras Sharma, D.O. Gastroenterology · Nashville, TN
- Nitendra P. Agarwal, M.D., M.P.H. Hospitalist · San Antonio, TX
- Amer Al-karadsheh, M.D. Endocrinology & Diabetes · Houston, TX
- Michael J. Downing, MD Psychiatry · Dallas, TX
- Nomita J. Kim, MD Family Medicine · Austin, TX
- Eduardo D. Luna, M.D. Endocrinology & Diabetes · Edinburg, TX
- Jara K. Mcdonald, M.D. Family Medicine · Marble Falls, TX
- Julio Rosenstock, M.D. Endocrinology & Diabetes · Dallas, TX
- Brandon Lawrence, M.D. Orthopedic Surgery · Salt Lake City, UT
- Stephan H. Jannach, MD Family Medicine · Danville, VA
- Anton Grasch, MD Family Medicine · Wenatchee, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Charter Research LLC $569,149
- Monroe Biomedical Research $481,370
- Indago Research & Health Center Inc $222,167
- Headlands Horizons LLC $201,415
- Great Lakes Clinical Trials $191,707
- Velocity Clinical Research Inc $178,351
- Institute for Liver Health LLC $161,705
- New Horizon Research Center $157,629
- Lucas Research Inc $142,086
- Clinvest Headlands LLC $120,015
- Texas Valley Clinical Research LLC $117,773
- Las Vegas Medical Research LLC $110,988
- Erg Holding Co LLC DBA St Louis Clinical Trials LLC $101,710
- Ima Evaluations LLC DBA Ima Clinical Research $97,480
- Peninsula Headlands LLC $92,843
- Studymetrix Research LLC $77,698
- Endocrine Ips PLLC $75,541
- Stamford Therapeutics Consortium $67,536
- Sociedad Espanola De Medicina De La Adolescencia $67,201
- Ascension Medical Group $58,446
- Medical Research PArtners $55,760
- Iowa Diabetes and Endocrinology Rsrch Cntr $55,461
- Danville Orthopedic Clinic Inc $49,949
- Arcturus Healthcare PLC, Troy Internal $40,466
- Cti Holdings Inc DBA Community Research Management Associates Inc $40,068
- Norcal Medical Research Inc $37,847
- Medication Management LLC $36,184
- Central Washington Health Services $35,652
- Rochester Clinical Research Inc $32,768
- Lucida Clinical Trials $31,359
- Suncoast Clinical Research $31,160
- True North Med at N Suffolk Pplc $30,310
- Tekton Research Inc $29,623
- Seen Medical of Ma PC DBA Knownwell $27,525
- Dent Neurosciences Research Center Inc $27,169
- Tribe Clinical Research LLC $23,652
- Northeast Research Institute $20,078
- Hope Research Institute LLC $18,575
- Louisville Metabolic $17,559
- Cotton Oneil Msd of Stormont Vail Healthcare $16,246
- Future Search Trials of Dallas LP $14,826
- Northshore University Healthsystem - Evanston Hospital, IL $11,539
- Diabetes and Endocrinology Consultants $5,413
- Clinvest Research LLC $4,670
- Knownwell $4,118
- Medex Healthcare Research Inc $4,017
- Endeavor Clinical Trials PA $3,110
- Cahaba Research $2,528
- Palos Verdes Medical Group $2,356
- Futuresearch Trials of Neurology LP $2,238
- Wenatchee Valley Hospital $1,899
- University at Buffalo $1,892
- Yshay Shlesinger MD $1,391
- North Suffolk Neurology $1,331
- Kerwin Memory Center LLC $794
- Andrew J Lewin Med DBA National Rsrch Institute $542
- Dallas Diabetes and Endo Research Center PA $472
- Pharmquest LLC $393
- Mountain View Clinical Research Inc $130
- $9
- Pacific Diabetes and Endocrine Center $2
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.