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A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Active, not recruiting · Phase 3 · NCT06292013

Conditions: Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a)

At a glance

Research payments reported, 2025
$61.8M
U.S. investigators named
253
Sites paid
222
Planned or actual enrollment
17,300

About the trial

Sponsor
Eli Lilly and Company
Tested
Lepodisiran Sodium (drug), Placebo (drug)
Dates
Started 2024-03-05; completion 2029-03
Results posted
Not yet

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke. The study drug will be administered subcutaneously (SC) (under the skin). Approximately 1700 additional participants will be enrolled in an addendum to explore Lp(a) lowering with an alternative dosing schema.

From ClinicalTrials.gov, last updated 2026-10-08. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $61.8M in research payments for this study in 2025 (542 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Care Access Research LLC $3.9M
  • Flourish Research Acquisition LLC $2.9M
  • Ima Evaluations LLC DBA Ima Clinical Research $2.1M
  • Eclipse Clinical Research $1.9M
  • Biopharma Informatic Inc $1.6M
  • Prx Research and Development LLC DBA Prx Research $1.5M
  • Piedmont Medical Research Associates Inc $1.5M
  • Advanced Clinical Research LLC $1.4M
  • Alliance for Multispecialty Research Lls $1.4M
  • Elligo Health Research Inc $1.3M
  • Revival Research Institute LLC $1.1M
  • Spectrum Clinical Research Inc $1.1M
  • Eastside Research Associates LLC $911,318
  • Velocity Clinical Research Inc $846,084
  • Biopharma Informatic Inc Research Center $811,567
  • Center for Advanced Research & Education LLC $741,874
  • Mount Sinai School of Medicine $715,766
  • Emory University Hospital, GA $684,193
  • Hospital of Univ of Pennsylvania, PA $672,640
  • North Georgia Clinical Research $652,374
  • Heart and Vascular Center Of $631,140
  • Clinical Research Philadelphia LLC $605,458
  • Regents of the University of California $598,582
  • The Cardiovascular Group PC $575,317
  • Valley Clinical Trials Inc $562,520
  • Clinical Research of West Florida Inc $560,625
  • Las Vegas Medical Research LLC $556,411
  • Sherman Clinical Research LLC $537,321
  • Brigham and Women's Hospital, MA $528,742
  • Medication Management LLC $517,354
  • Tribe Clinical Research LLC $517,128
  • Jacksonville Center for Clinical Research $487,755
  • Renstar Inc $483,194
  • Cardiology Associates of Fairfield $476,721
  • Wcr Associates LLC DBA Wellness Clinical Research $470,462
  • American Health Network of in LLC $468,992
  • Baylor College of Medicine $467,554
  • K2 Medical Research LLC $455,939
  • Board of Trustees of the Leland Stanford Jr Univ $445,593
  • Medstar Health Research Institute $418,614
  • Regents of the University of Colorado $404,398
  • American Clinical Trials LLC $401,693
  • Advanced Research for Health Improvement LLC $395,373
  • Clinical Investigation Specialists Inc $379,228
  • Chase Medical Research LLC $375,299
  • Clinical Research Institute of Arizona LLC $369,956
  • New York University $359,149
  • Clinvest Headlands LLC $352,362
  • Triamed Health Inc Triad Clinical Trials LLC $351,652
  • Cr Services Acquisition US LLC $347,053
  • Birmingham Clinical Research Ins Nova Law $336,687
  • Clearwater Cardiovascular $334,291
  • Chicago Clinical Research Institute Inc $323,191
  • Intermountain Health Utah Valley Hospital, UT $322,792
  • Little River Clinical Research LLC $319,677
  • Prairie Education and Research Coop $307,469
  • Southeastern Clinical Research Institute LLC $307,404
  • Sivalingam Medical Corporation Inc $303,945
  • Pima Heart $299,138
  • Orlando Family Physicians $290,541
  • Utah Cardiology $286,922
  • Anderson Medical Research LLC $283,448
  • Progressive Medical Concepts LLC $280,101
  • Neighborhood Healthcare $277,111
  • Metropolitan Cardiovascular Consultants LLC $270,324
  • Norman E Lepor, MD Inc $266,047
  • Ronald Reagan UCLA Medical Center, CA $264,717
  • Arcturus Healthcare PLC, Troy Internal $259,271
  • Desert Med Group DBA Desert Oasis Hlthcare $253,141
  • Preferred Primary Care Physicians Inc $250,991
  • Cardiology Consultants of Philadelphia $247,941
  • Wake Forest University Health Sciences $246,443
  • Morristown Medical Center, NJ $245,178
  • Endocrine Ips PLLC $244,966
  • Davita Clinical Research $242,705
  • Biomedical Research Alliance of New York $242,604
  • Iowa Diabetes and Endocrinology Rsrch Cntr $237,545
  • East Coast Institute for Research $235,683
  • Bridgeport Hospital, CT $234,959
  • Texas Institute of Cardiology PA $234,647
  • Inpatient Research Clinic DBA Las PAlmas Research Center $232,582
  • South Texas Clinical Research $231,868
  • Scripps Mercy Hospital, CA $226,465
  • Wellspan Health $225,655
  • Hb Clinical Trials Inc $223,944
  • Cardiovascular Research Foundation of Southern California $223,556
  • Elegant Research and Development LLC $222,565
  • South Florida Wellness and Clinical Resear $221,797
  • Baylor Research Institute $220,179
  • Studymetrix Research LLC $218,739
  • Palm Research Center Inc $217,052
  • Atlanta Diabetes Associates $214,526
  • Capital Area Research LLC $207,686
  • Los Angeles Biomedical $205,470
  • Artemis Headlands LLC $204,784
  • Care Institute LLC $202,043
  • St Josephs Hospital and Medical Center, AZ $200,772
  • Clinical Advancement Center PLLC $200,303
  • Forty Third Medical Associates $199,536
  • Invivocure LLC $197,404

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.