A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation
Active, not recruiting · Phase 2 · NCT06299098
Conditions: Obesity
At a glance
- Research payments reported, 2025
- $32.0M
- U.S. investigators named
- 67
- Sites paid
- 49
- Planned or actual enrollment
- 1,005
About the trial
- Sponsor
- Regeneron Pharmaceuticals
- Tested
- Trevogrumab-Part A (drug), Trevogrumab-Part B and Part C (drug), Garetosmab (drug), Semaglutide (drug), Matching Placebo-Part A (drug), Matching Placebo-Trevogrumab (drug), Matching Placebo-Garetosmab (drug)
- Dates
- Started 2024-03-13; completion 2026-10-21
- Results posted
- Not yet
This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®). This study will be done in 3 parts, Part A, Part B, and Part C where different study drugs will be tested. Part A of the study is focused on healthy participants. Part B and C of the study is focused on participants with obesity. The aim of Part A of the study is to see how safe and tolerable the study drug is in healthy participants. The aim of Part B and Part C of the study is to see how safe and effective the study drug is when combined with Wegovy. Parts A, B, and C of the study are looking at several other research questions, i…
From ClinicalTrials.gov, last updated 2026-09-01. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Regeneron Pharmaceuticals, Inc. reported $32.0M in research payments for this study in 2025 (5,002 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Almena Free, M.D. Internal Medicine · Anniston, AL
- Randall L. Quinn, MD Family Medicine · Cullman, AL
- Kenneth Steil, D.O. Dermatology · Scottsdale, AZ
- Amina Z. Haggag, M.D. Family Medicine · Northridge, CA
- Yehuda Handelsman, M.D. Endocrinology & Diabetes · Tarzana, CA
- Jeffrey S. Overcash, MD Emergency Medicine · Chula Vista, CA
- Kalpesh Patel, M.D. Nephrology (Kidney) · Calabasas, CA
- Elaine Watkins, D.O Internal Medicine · San Diego, CA
- Malvin Yan, D.O. Nephrology (Kidney) · South Gate, CA
- Douglas Young, MD Internal Medicine · Sacramento, CA
- Jude A. Acloque, M.D. Internal Medicine · Boynton Beach, FL
- Darlene Bartilucci, MD Family Medicine · Jacksonville, FL
- Howard N. Chipman III, M.D. Family Medicine · Oldsmar, FL
- Herman J. Downey, MD Family Medicine · Jacksonville, FL
- Michael Paul Gimness, M.D. Family Medicine · Plant City, FL
- Robinson N. Koilpillai, M.D. Family Medicine · Winter Haven, FL
- Lon D. Lynn, D.O. Family Medicine · Tampa, FL
- John P. Nardandrea JR., MD Family Medicine · Ocala, FL
- Robert G. Perry, M.D Internal Medicine · Pembroke Pines, FL
- Jose E. Rodriguez, MD Internal Medicine · Fort Myers, FL
- Jeffrey Schneider, M.D. Gastroenterology · Coral Springs, FL
- Nadia G. Cameron, M.D. Family Medicine · Lawrenceville, GA
- Christopher P. Recknor, M.D. Internal Medicine · Gainesville, GA
- Bram Wieskopf, MD Internal Medicine · Woodstock, GA
- David Fitz-patrick, M.D. Specialist · Honolulu, HI
- Gary W. Soucie, MD Family Medicine · Blackfoot, ID
- Diana T. Widicus, MD Family Medicine · Rochester, IL
- Rita Schmid, M.D. Internal Medicine · South Bend, IN
- Katherine J. Willingham, MD Internal Medicine · Topeka, KS
- Harold E. Bays, MD Endocrinology & Diabetes · Louisville, KY
- Matthew D. Wenker, MD Internal Medicine · Erlanger, KY
- Adil A. Fatakia, M.D. ENT (Otolaryngology) · Marrero, LA
- Clint C. Guillory, MD Family Medicine · Monroe, LA
- Andres J. Acosta, M.D., PH.D. Gastroenterology · Rochester, MN
- Benjamin R. Cook, DO Family Medicine · Jefferson City, MO
- Ralph J. Duda JR., M.D. Endocrinology & Diabetes · Springfield, MO
- David G. True, D.O. Rheumatology · Nixa, MO
- Randall T. Huling, MD Family Medicine · Olive Branch, MS
- Bob Hutchins Internal Medicine · Jackson, MS
- Demetri W. Marshall, M.D. Family Medicine · Port Gibson, MS
- John Pullman, MD Internal Medicine · Butte, MT
- Jamy D. Ard, MD Internal Medicine · Winston Salem, NC
- Kevin Cannon, M.D. Hospitalist · Wilmington, NC
- Robert E. Mcneill, M.D. Internal Medicine · Salisbury, NC
- Joseph E. Moran, M.D. Internal Medicine · Statesville, NC
- John Rubino, MD Internal Medicine · Raleigh, NC
- Jonathan P. Wilson, DO Family Medicine · Hickory, NC
- Michael A. Hassman, DO Family Medicine · Berlin, NJ
- Lisa B. Connery, M.D. Family Medicine · Norman, OK
- Alan Kivitz, MD Rheumatology · Duncansville, PA
- Maribel Campos Rivera, MD Integrative Medicine · San Juan, PR
- Grisell Ortiz Lasanta, MD Internal Medicine · San Juan, PR
- Christopher M. Davis, DO Family Medicine · Greenville, SC
- Ronald K. Mayfield, M.D. Endocrinology & Diabetes · Spartanburg, SC
- Richard E. Mills, MD Internal Medicine · Mt Pleasant, SC
- Rica Santiago, M.D Internal Medicine · Mt Pleasant, SC
- Charles A. Crump JR., MD Internal Medicine · Chattanooga, TN
- Bernard Grunstra, MD Internal Medicine · Bristol, TN
- Rickey D. Manning, MD Family Medicine · Knoxville, TN
- Paul H. Wakefield, MD Family Medicine · Knoxville, TN
- Lisa J. Blair, MD Family Medicine · Aransas Pass, TX
- Alex Guevara JR., D.O. Family Medicine · Fort Worth, TX
- Julio Rosenstock, M.D. Endocrinology & Diabetes · Dallas, TX
- Javier A. Vasallo, M.D. Internal Medicine · El Paso, TX
- Michelle D. Welch, MD Endocrinology & Diabetes · Shavano Park, TX
- James R. Clark, MD Internal Medicine · Charlottesville, VA
- George H. Freeman, M.D. Research Study Specialist · Newport News, VA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Accellacare US Inc $7.4M
- Jpj Research Inc $2.3M
- Precision Clinical Research LLC $2.1M
- Tandem Intermediate LLC $1.9M
- Sky Clinical Research Network Group $1.8M
- Velocity Clinical Research Inc $1.4M
- Qcare Site Services Inc $1.3M
- Elligo Health Research Inc $1.1M
- Jacksonville Center for Clinical Research $935,901
- Southwest General Healthcare Center $886,268
- Center for Advanced Research & Education $885,706
- Olive Branch Family Medical Center $862,826
- North Georgia Clinical Research $853,478
- Clinical Research of West Florida Inc $709,054
- Fundacion De Investigacion De Diego Inc $624,987
- Northern California Research $476,462
- Clinical Research of Central Florida Inc $446,828
- Altoona Center for Clinical Research PC $439,541
- Pinnacle Research Group LLC $390,031
- Chattanooga Medical Research LLC $387,800
- Prosciento Inc $369,955
- Charlottesville Medical Research Centre LLC $362,353
- Ima Evaluations LLC $338,776
- David Fitz PAtrick MD Inc $325,214
- Health Research of Hampton Roads Inc $317,060
- Consano Clinical Research LLC $306,208
- Valley Institute of Research LLC $282,833
- Puerto Rico Consortium for Clinical Investigation Inc $278,214
- Mayo Clinic $268,493
- Louisville Metabolic and Atherosclerosis Research Center $211,667
- Clinvest Headlands LLC $193,562
- Cullman Clinical Trials $188,291
- Alliance for Multispecialty Research LLC $186,359
- Anaheim Clinical Trials LLC $163,165
- Hassman Research Institute LLC $160,569
- Mercury Street Medical Group PLLC $158,337
- Elite Clinical Trials Lllp $139,209
- Tribe Clinical Research LLC $132,451
- Metabolic Institute of America $120,390
- Cognitive Clinical Trials LLC $117,024
- Prairie Education & Research Cooperative $78,070
- Cotton Oneil Clinic Revocable Trust $61,856
- Wake Forest University Health Sciences $51,026
- Encore Medical Research of Boynton Beach LLC $21,541
- Tandem Clinical Research LLC $16,863
- Panax Clinical Research LLC $13,855
- Renstar LLC $12,596
- Medresearch Inc $7,543
- Coastal Carolina Research Center LLC $300
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.