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Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne

Recruiting · Phase 1, Phase 2 · NCT06316297

Conditions: Acne

At a glance

Research payments reported, 2025
$4.4M
U.S. investigators named
56
Sites paid
48
Planned or actual enrollment
800

About the trial

Sponsor
Sanofi Pasteur, a Sanofi Company
Tested
Acne mRNA vaccine (biological), Placebo (other)
Dates
Started 2024-04-05; completion 2028-11-30
Results posted
Not yet

The purpose of the trial is to evaluate the safety, efficacy and immunogenicity of up to 3 intramuscular injections of the Acne mRNA vaccine candidate at up to four dose levels in adult participants aged 18 to 45 years with moderate to severe acne. This trial will consist of a Core Study followed by an optional Long-Term Extension (LTE). The Core Study will consist of: * Two cohorts evaluating the 2-administration regimen (Cohorts A): Sentinel Cohort A and Main Cohort A. * Two cohorts evaluating the 3-administration regimen (Cohorts B): Sentinel Cohort B and Main Cohort B. Participants from Sentinel Cohorts A and B and from Main Cohort A will be invited to an additional 30-month follow up…

From ClinicalTrials.gov, last updated 2026-08-21. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Sanofi Pasteur Inc. reported $4.4M in research payments for this study in 2025 (302 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Michigan Institute of Research $1.5M
  • Delricht Llc $367,729
  • Elias Research Associates Llc $344,115
  • Universal Medical and Research Center, Llc $236,972
  • Lone Star Clinical Research Katy $231,916
  • Clinosis $195,879
  • Joseph Raoof MD $190,102
  • Wellquest Clinical $151,624
  • Palm Harbor Dermatology PA PAlm Harbor Dermatology PA Dba True Clinical Research $114,276
  • Encore Medical Research Llc $112,789
  • Jacksonville Center for Clinical Research $100,482
  • Encore Medical Research of Boynton Beach Llc $80,729
  • California Research Foundation $75,190
  • Las Vegas Clinical Trials, Llc $52,144
  • Sea Mar Seattlehealth Home Crcsg $51,511
  • Moore Clinical Research $50,968
  • Alliance for Multispecialty Research,llc $47,975
  • West Los Angeles Medical Center $45,731
  • Trial Management Associates, Llc $35,295
  • Northridge Clinical Trials Llc $33,306
  • Health and Life Research Institute, Llc $31,741
  • Paradigm Clinical Research Centers, Inc $29,207
  • Lynn Helath Science Inst $27,272
  • Innovo Research Llc $21,000
  • Medisearch Llc $20,514
  • Francisco Badar MD Inc $20,316
  • Forward Clinical Trials Llc Forcare Clinical Research $19,381
  • Alliance Clinical Holdings Llc $18,002
  • Scla Management, Llc $17,990
  • Carbon Health Technolgies Inc $16,581
  • Boeson Research $16,466
  • Center for Clinical Studies Ltd LLP $16,144
  • Northshore University Healthsystem - Evanston Hospital, IL $14,500
  • Zenith Clinical Research $14,327
  • Physicians Research Group II Llc $14,115
  • Kerlo Research $12,500
  • K2 Summit Research Llc $11,540
  • Sandhill Research, Llc $11,500
  • Univarsal Research Group Llc $11,190
  • Artemis Headlands Llc $11,075
  • Dawes Fretzin Clinical Research Gro LLC $10,133
  • Metromed Clinical Trials $10,075
  • Pmg Research,inc Dba Pmg Research of Charleston,llc $10,000
  • Dermresearch P A $5,946
  • Empire Clinical Research $5,558
  • Profound Research Llc $3,884
  • The Research and Education Institute for Thr $2,948
  • Southcoast Research Center, Inc $1,973

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.