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A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants

Active, not recruiting · Phase 2, Phase 3 · NCT06345339

Conditions: Hypothyroidism

At a glance

Research payments reported, 2025
$24.7M
U.S. investigators named
140
Sites paid
190
Planned or actual enrollment
2,701

About the trial

Sponsor
AbbVie
Tested
Armour Thyroid (drug), Levothyroxine (drug)
Dates
Started 2024-04-26; completion 2028-06
Results posted
Not yet

This study will evaluate the efficacy and safety of Armour Thyroid treatment compared with synthetic T4 in subjects who have primary hypothyroidism and are currently stabilized (i.e., in-range thyroid-stimulating hormone \[TSH\]) on synthetic T4 treatment. This study will also therefore evaluate the efficacy and safety of dose conversion from synthetic T4 therapy to Armour Thyroid therapy.

From ClinicalTrials.gov, last updated 2026-10-13. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $24.7M in research payments for this study in 2025 (1,680 payments).

Products named: Armour Thyroid

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Lucas Research Inc $1.6M
  • Accellacare US Inc $967,020
  • East Coast Institute for Research $761,257
  • Texas Diabetes & Endocrinology PA $596,121
  • Alsa Research LLC $577,120
  • Research Physicians Network LLC $574,083
  • Ivy-Joan Madu $456,407
  • Northeast Research Institute $452,377
  • Advanced Research Inc $444,289
  • West Orange Endocrinology PA $438,308
  • Diabetes and Endocrinology Associat $407,628
  • Profound Research LLC $391,641
  • Carolina Endocrine Associates LLC $389,268
  • Jacksonville Ctr for Clinical Rsrch $381,622
  • Trial Management Associates LLC $364,250
  • Thomas Jefferson University $356,890
  • Isis Clinical Research Center $348,978
  • Academy of Diabetes Thyroid $347,356
  • Encore Medical Research LLC $337,713
  • Emory University Hospital, GA $332,809
  • Endocrine Research Solutions $329,063
  • Osvaldo A Brusco MD PA $328,220
  • Central Research Associates Inc $327,945
  • Palm Research Center Inc $319,124
  • Gcm Medical Group Psc $315,740
  • Rainier Crc LLC $296,064
  • Diagnamics Inc $293,320
  • Columbus Regional Research Institut $292,374
  • Louisville Metabolic And $280,059
  • Lifedoc Research PLLC $276,626
  • Physicians Research Associates LLC $256,901
  • Atlas Intermediate LLC $242,333
  • Diabetes and Glandular $241,254
  • Jefferson City Medical Group $235,591
  • Med Research of Florida LLC $232,685
  • Diabetes Endocrinology Specialists $222,471
  • Comprehensive Medical & Research $217,352
  • Metabolic Research Institute Inc $217,253
  • West Broadway Clinic PC $216,746
  • Nyc Research Inc $208,682
  • Southern Endocrinology Associates $207,663
  • Northwestern University $205,946
  • Ocean Blue Medical Research Center $201,055
  • Diabetes & Thyroid Ctr of Ft Worth $195,785
  • Endocrine and Psychiatry Center $195,146
  • Lynn Health Science Institute $195,128
  • Donald Guthrie Fndn for Education $187,585
  • Rocky Mountain Clinical Research $183,379
  • Adult Medicine of Lake County Inc $181,457
  • Bryan Medical Center, NE $181,142
  • Iowa Diabetes and Endocrinology $178,771
  • Carteret Medical Group LLC $175,294
  • Clinical Research Institute Of $174,890
  • Pennington Biomedical Research $174,328
  • Univ of Florida Board of Trustees $172,926
  • Clinical Research Investigator $171,144
  • Innovative Research of West Florida $169,653
  • Cotton Oneil Clinic Revocable Trust $167,203
  • Northeast Clinical Research Of $165,491
  • Diablo Clinical Research Inc $163,160
  • Cr Services Acquisition US LLC $159,374
  • Texas Valley Clinical Research LLC $158,838
  • Facey Medical Foundation $155,318
  • The Research Foundation for The $153,806
  • Brcr Medical Center Inc $152,374
  • Mindful Medical Research $152,300
  • Midstate Endocrine Associates $151,428
  • Tekton Research LLC $143,828
  • Physicians East PA $138,740
  • Elite Research Center LLC $136,392
  • Multicare Good Samaritan Hospital, WA $133,772
  • Care Access Research LLC $126,367
  • Peter Bressler MD $125,975
  • Albany Medical College $115,591
  • Planit Research PLLC $114,907
  • Consano Clinical Research LLC $112,365
  • San Fernando Valley Health $110,499
  • Veritas Research Group LLC $105,402
  • Velocity Clinical Research Inc $104,504
  • Atlanta Diabetes Associates PC $102,561
  • Pacific Diabetes and Endocrine Ctr $102,318
  • John Muir Physician Network $97,708
  • Scripps Mercy Hospital, CA $96,624
  • Cleveland Clinic, OH $95,876
  • Billings Clinic Hospital, MT $88,858
  • South Florida Clinical Research $88,853
  • Juno Research LLC $84,915
  • Chattanooga Medical Research LLC $84,420
  • All Medical Research LLC $81,927
  • Southern California Permanente Med $80,381
  • Mercy Research $79,632
  • Jellinger and Lerman MD PA $76,403
  • Tufts Medical Center, MA $74,304
  • Nola Care Clinical Research LLC $73,287
  • DBA Omega Clinical Research LLC $70,447
  • Physicians Clinic Inc $69,171
  • Palmetto Clinical Research $56,793
  • University of Tennessee $56,260
  • Endocrine Associates $54,707
  • Foundation Medical PArtners $49,721

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.