Safety and Efficacy of 0.75% Phentolamine Ophthalmic Solution in Subjects With Post-refractive Surgery Visual Disturbances
Completed · Phase 3 · NCT06349759
Conditions: Mesopic Vision, Night Vision Loss
At a glance
- Research payments reported, 2025
- $3.4M
- U.S. investigators named
- 38
- Sites paid
- 41
- Planned or actual enrollment
- 200
About the trial
- Sponsor
- Opus Genetics, Inc (with Viatris Inc.)
- Tested
- phentolamine ophthalmic solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist (drug), Placebo (drug)
- Dates
- Started 2024-04-01; completion 2026-02-19
- Results posted
- Yes
Safety and efficacy of 0.75% Phentolamine Ophthalmic Solution to improve mesopic low contrast visual acuity in subjects with post-refractive surgery visual disturbances.
From ClinicalTrials.gov, last updated 2026-10-26. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Oyster Point Pharma, Inc. reported $3.4M in research payments for this study in 2025 (310 payments).
Products named: Ryzumvi
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Marc Bloomenstein, OD Optometrists · Scottsdale, AZ
- Michael J. Depenbusch, M.D. Ophthalmology · Chandler, AZ
- Matthew D. Hammond, MD Ophthalmology · Mesa, AZ
- Benjamin Heller Ophthalmology · Phoenix, AZ
- Daniel H. Chang, MD Ophthalmology · Bakersfield, CA
- Sherif M. El-harazi, MD MPH Ophthalmology · Glendale, CA
- Damien F. Goldberg, M.D. Ophthalmology · Torrance, CA
- David J. Schanzlin, M.D. Ophthalmology · San Diego, CA
- David L. Wirta, MD Ophthalmology · Newport Beach, CA
- Keith C. Charles, MD Ophthalmology · Mount Dora, FL
- Frank W. Mcdonald, M.D. Ophthalmology · Jacksonville, FL
- Mark Paauw, MD Ophthalmology · Jacksonville, FL
- Christopher Pearson, O.D. Optometrists · Longwood, FL
- Don J. Perez, MD Ophthalmology · Tampa, FL
- Jerry L. Robben Optometrists · St Augustine, FL
- Bruce A. Segal, MD Ophthalmology · Delray Beach, FL
- Philip L. Shettle, D.O. Ophthalmology · Largo, FL
- Erin C. Esfahani, NP Nurse Practitioners · Marietta, GA
- Kathleen A. Kelley, O.D. Optometrists · Indianapolis, IN
- Shane R. Kannarr, OD Optometrists · Pittsburg, KS
- Bradley R. Kwapiszeski, M.D. Ophthalmology · Shawnee Mission, KS
- Jason E. Stahl, MD Ophthalmology · Overland Park, KS
- John C. Meyer, MD Ophthalmology · Louisville, KY
- Mahdi Basha, D.O. Ophthalmology · Fraser, MI
- Anthony J. Verachtert, O.D. Optometrists · Kansas City, MO
- Carol A. Aune, OD Optometrists · Raleigh, NC
- Tracie Malsom, OD Optometrists · Fargo, ND
- Paul J. Hartman, MD Ophthalmology · Rochester, NY
- George Zikos, O.D Optometrists · New York, NY
- Shane A. Foster, O.D. Optometrists · Athens, OH
- Stephen M. Montaquila, O.D. Optometrists · Warwick, RI
- David G. Evans, OD Optometrists · Memphis, TN
- Bradley N. Hines, O.D. Optometrists · Memphis, TN
- Gary W. Jerkins, MD Ophthalmology · Nashville, TN
- Gregory D. Parkhurst, M.D. Ophthalmology · San Antonio, TX
- Kyle M. Rhodes, MD Ophthalmology · Lakeway, TX
- Michele R. Avila, O.D. Optometrists · Draper, UT
- Randy B. Carter, O.D. Optometrists · Salt Lake City, UT
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Eye Doctors of Arizona $423,038
- Eye Research Foundation, Inc $378,506
- Global Research Management Inc $329,146
- Total Eye Care, PA $283,144
- Arizona Eye Center $242,333
- Segal Drug Trials, Inc $164,619
- Oculus Research, Inc. $142,553
- Red River Research PArtners $119,361
- Sabal Eye Care $115,288
- Gordon Schanzlin New Vision Institute $113,414
- Shettle Eye Research, Inc. $104,354
- West Bay Eye Associates $91,754
- Mrb Eye Consultants, LLC $83,116
- Moyes Eye Center $77,986
- Kannar Eye Center $77,230
- Fraser Eye Care Center $70,097
- Price Vision Group $66,148
- Durrie Vision $58,172
- Optometry Group PLLC $55,957
- Rochester Ophthalmological Group $55,200
- Carrot Eye Center $55,086
- Pnv Clinical Research LLC $53,736
- Advance Vision Research LLC $33,451
- Mid Florida Eye Center, P.a. $24,319
- Levenson Eye Associates $23,838
- Athens Eye Care $23,787
- Lake Travis Eye and Laser Center / Revolution Research $17,966
- Heart of America Eye Care, P.a $16,288
- Piedmont Eye Center $14,660
- Bergstrom Eye Research $9,918
- Lobue Laser and Eye Medical Center, Inc. $9,510
- The Eye Institute $9,432
- Butchertown Clinical Trials $8,395
- Eye Research Foundation $7,284
- Wolstan & Goldberg Eye Associates $6,866
- Oculus Research $6,198
- Hoopes, Durrie, Rivera Research $1,496
- Empire Eye and Laser Center $1,452
- Center for Ophthalmic and Vision Research $1,200
- International Research Center $790
- Bowden Eye & Associates $600
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.