A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 1 (ALKS 2680-201)
Completed · Phase 2 · NCT06358950
Conditions: Narcolepsy Type 1
At a glance
- Research payments reported, 2025
- $2.1M
- U.S. investigators named
- 37
- Sites paid
- 37
- Planned or actual enrollment
- 92
About the trial
- Sponsor
- Alkermes, Inc.
- Tested
- ALKS 2680 (drug), Placebo (drug)
- Dates
- Started 2024-03-24; completion 2025-07-31
- Results posted
- Not yet
The purpose of this research study is to assess the safety and efficacy of ALKS 2680 compared to placebo, including whether participants taking ALKS 2680 experience a greater decrease in sleepiness and a decrease in cataplexy ("sudden loss of muscle control"), compared to participants taking placebo alone.
From ClinicalTrials.gov, last updated 2026-06-10. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Alkermes, Inc. reported $2.1M in research payments for this study in 2025 (1,177 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Chad M. Ruoff, M.D. Sleep Medicine · Scottsdale, AZ
- Emmanuel J. Mignot, M.D Sleep Medicine · Stanford, CA
- Daniel Norman, M.D. Sleep Medicine · Los Angeles, CA
- Andrew O. Schreiber, MD Neurosurgery · Santa Ana, CA
- Stephen P. Duntley, MD Sleep Medicine · Aurora, CO
- Faisal A. Fakih, MD Specialist · Winter Park, FL
- Daniel G. Lorch, M.D. Pulmonology · Brandon, FL
- Edward Mezerhane, MD Sleep Medicine · Miami, FL
- Dragos G. Zanchi, M.D Pulmonology · Brandon, FL
- Dennis M. Lacey, MD Neurology · Atlanta, GA
- Phillip W. Nowlin, MD Family Medicine · Carrollton, GA
- Charles C. Wells, M.D. Sleep Medicine · Macon, GA
- Patrick E. Whitten, M.D. Pulmonology · Peoria, IL
- James P. Maynard, M.D. Neurology · Fort Thomas, KY
- Vishal Saini, M.D. Sleep Medicine · Saginaw, MI
- Rahul B. Sangal, M.D. Sleep Medicine · Bloomfield Hills, MI
- Ruth M. Benca, MD PHD Psychiatry · Winston Salem, NC
- Daniel T. Garber, M.D. Sleep Medicine · Concord, NC
- Andrew Krystal, M.D. Psychiatry · Durham, NC
- Thomas P. Stern, M.D. Pulmonology · Huntersville, NC
- Kevin J. Reichmuth, M.D. Pulmonology · Lincoln, NE
- Matthew J. Davis, MD Neurology · Middletown, NJ
- Alec B. Platt, M.D Pulmonology · Schenectody, NY
- Bruce C. Corser, MD Pulmonology · Cincinnati, OH
- Ryan S. Drake, DO Neurology · Canton, OH
- Nancy R. Foldvary-schaefer, DO Sleep Medicine · Cleveland, OH
- Asim Roy, M.D. Sleep Medicine · Dublin, OH
- Zhanna Fast, MD Internal Medicine · Philadelphia, PA
- Anne M. Morse, DO Child Neurology · Danville, PA
- Richard K. Bogan, M.D. Pulmonology · Columbia, SC
- Joshua J. Lennon, MD Neurology · Cordova, TN
- James M. Andry, MD Sleep Medicine · San Antonio, TX
- John D. Hudson, M.D. Sleep Medicine · Austin, TX
- Gerard J. Meskill, MD Sleep Medicine · Sugar Land, TX
- Henry S. Scheuller, M.D. Sleep Medicine · Jbsa Lackland, TX
- Jerald H. Simmons, MD Sleep Medicine · Houston, TX
- David T. Plante, MD Sleep Medicine · Madison, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- The Board of Trustees of the Leland Stanford Junior University $432,969
- Futuresearch Trials of Neurology, LLC. $136,340
- Clinical Site PArtners, LLC. $113,758
- Intrepid Research, LLC. $99,530
- Sound Asleep Research, Inc. $96,059
- Research Carolina Elite, LLC. $75,402
- Teradan Clinical Trials $62,295
- Bryan Medical Center, NE $61,992
- Sleep Therapy & Research Center $56,468
- Mayo Clinic Hospital, AZ $47,979
- Advanced Respiratory and Sleep Medicine, PLLC $43,777
- Osf Heart of Mary Medical Center, IL $43,626
- University of Colorado Denver Hospital $42,829
- UCSF Langley Porter Psychiatric Hospital and Clinics, CA $42,690
- The Board of Regents of the University of Wisconsin System $42,496
- Sleep Practitioners, LLC $41,875
- Neurotrials Research, Inc. $39,821
- Delta Waves Sleep Disorders and Research Center $37,287
- Thomas Jefferson University $36,627
- Neuroscience Research Center, LLC. $36,546
- Cleveland Clinic, OH $36,214
- Geisinger Clinic $31,676
- Respiratory Specialists $30,134
- Ohio Sleep Medicine and Neuroscience Institute $30,040
- Pharmaseek, LLC. dba Wcg Site Network $29,812
- Santa Monica Clinical Trials $29,562
- Community Research Management Associates, Inc. $29,144
- Bogan Sleep Consultants, LLC $28,246
- Tricoastal Narcolepsy and Sleep Disorders Center, PLLC. $28,123
- Clinical Research Institute $28,074
- Neurology Clinic PC $27,024
- Patient First MD $26,757
- Sds Clinical Trials, Inc. $25,933
- Pharmadev Clinical Research Institute, LLC $24,205
- Clinical Neurophysiology Services PC $23,724
- Comprehensive Sleep Medicine Associates Csma $20,461
- Wake Forest University Health Sciences $16,257
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.