A Study to Investigate the Safety and Immunogenicity of the Quadrivalent Influenza mRNA Vaccines in Adults Aged 18 Years and Above
Completed · Phase 1, Phase 2 · NCT06361875
Conditions: Influenza Immunization, Healthy Volunteers
At a glance
- Research payments reported, 2025
- $1.8M
- U.S. investigators named
- 21
- Sites paid
- 19
- Planned or actual enrollment
- 908
About the trial
- Sponsor
- Sanofi Pasteur, a Sanofi Company
- Tested
- Quadrivalent Influenza mRNA Vaccine MRT5421 (biological), Quadrivalent Influenza mRNA Vaccine MRT5424 (biological), Quadrivalent Influenza mRNA Vaccine MRT5429 (biological), Quadrivalent Influenza Standard Dose Vaccine (biological), Quadrivalent Influenza High-Dose Vaccine (biological), Quadrivalent Recombinant Influenza Vaccine (biological)
- Dates
- Started 2024-04-01; completion 2025-06-09
- Results posted
- Yes
The purpose of this study was to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of different formulations of Quadrivalent Influenza Vaccine (QIV) messenger ribonucleic acid (mRNA) (MRT5421, MRT5424, and MRT5429) compared to an active control (QIV- standard dose (SD), QIV- high dose (HD) \[adults ≥ 65 years of age only\], or quadrivalent recombinant influenza vaccine (RIV4)) in adults 18 years of age and older.
From ClinicalTrials.gov, last updated 2026-08-04. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Sanofi Pasteur Inc. reported $1.8M in research payments for this study in 2025 (125 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Todd Bertoch, M.D. Anesthesiology · Prescott, AZ
- Donald M. Brandon, M.D. Internal Medicine · San Diego, CA
- Barry Heller, M.D. Emergency Medicine · Long Beach, CA
- Jeffrey S. Overcash, MD Emergency Medicine · Chula Vista, CA
- Jose F. Cardona, M.D. General Practice · Miami, FL
- Timothy H. Elder, M.D. Family Medicine · Gainesville, FL
- Mark E. Kutner, MD Internal Medicine · Miami, FL
- Bruce G. Rankin, D. O. Family Medicine · Deland, FL
- Craig S. Shapiro, D.O. ENT (Otolaryngology) · Hollywood, FL
- Blair Brengle, MD Family Medicine · Indianapolis, IN
- Martha S. Fanning, M.D. Emergency Medicine · Overland Park, KS
- Crystal D. Faudere, D.O. Family Medicine · El Dorado, KS
- Mark S. Adams, M.D. Internal Medicine · London, KY
- Scott P. Striplin, M.D. OB-GYN (Obstetrics & Gynecology) · Covington, LA
- Brandon J. Essink, M.D. Family Medicine · Creighton, NE
- Charles Harper JR., MD Internal Medicine · Norfolk, NE
- Matthew G. Davis, MD Family Medicine · Rochester, NY
- Gustavo R. Albizu, M.D. General Practice · Morovis, PR
- Rica Santiago, M.D Internal Medicine · Mt Pleasant, SC
- Jerry L. Punch, MD Family Medicine · Knoxville, TN
- Parke J. Hedges OB-GYN (Obstetrics & Gynecology) · San Antonio, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Indago Research and Health Center Inc $362,706
- California Research Foundation $189,287
- Velocity Clinical Research,inc $181,274
- Research Centers of America $172,394
- Coastal Carolina Research Center,incorporation $154,141
- Flourish Research, San Antonio $137,970
- Alliance for Multispecialty Research,llc $111,454
- Compass Pointe $89,123
- Wellness Clinical Research (wcr) $87,830
- Long Beach Clinical Trials Llc $65,465
- University Clinical Research Dela Llc $63,839
- Rochester Clinical Research,inc $50,278
- Long Beach Clinical Trials $43,782
- Flourish Research Suncoast Research Group $41,280
- Simedhealth Llc $22,334
- Velocity Clinical Research $19,111
- Indago Research Health Center $14,850
- The Children's Mercy Hospital, MO $13,500
- Research Centers of America,llc $2,820
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.