A Study of I-DXd in Combination With Atezolizumab With or Without Carboplatin as First-Line Induction or Maintenance in Subjects With Extensive Stage-Small Cell Lung Cancer (IDeate-Lung03)
Recruiting · Phase 1, Phase 2 · NCT06362252
Conditions: Extensive Stage-small Cell Lung Cancer
At a glance
- Research payments reported, 2025
- $2.4M
- U.S. investigators named
- 26
- Sites paid
- 33
- Planned or actual enrollment
- 123
About the trial
- Sponsor
- Daiichi Sankyo (with Merck Sharp & Dohme LLC)
- Tested
- Ifinatamab deruxtecan (drug), Atezolizumab (drug), Carboplatin (drug)
- Dates
- Started 2024-07-22; completion 2028-02-20
- Results posted
- Not yet
This study is designed to evaluate the safety and efficacy of ifinatamab deruxtecan (I-DXd) in combination with immune checkpoint inhibitor (ICI) atezolizumab with or without carboplatin in participants with extensive stage-small cell lung cancer (ES-SCLC) in the first-line (1L) setting.
From ClinicalTrials.gov, last updated 2026-10-01. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Daiichi Sankyo Inc. reported $2.4M in research payments for this study in 2025 (1,832 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Vinicius Ernani Hematology & Oncology · Scottsdale, AZ
- Yaser Homsi, M.D. Hematology & Oncology · Huntington Beach, CA
- Aakash Desai, MBBS Hematology & Oncology · Farmington, CT
- Jhanelle Gray, MD Internal Medicine · Tampa, FL
- Yanyan Lou, MD Hematology & Oncology · Jacksonville, FL
- Tarek M. Mekhail, M.D. Hematology & Oncology · Orlando, FL
- Manish R. Patel, MD Medical Oncology · Sarasota, FL
- Vamsidhar Velcheti, MD Hematology & Oncology · Jacksonville, FL
- Bilal F. Anouti, MD Hematology & Oncology · Chicago, IL
- Jyoti Patel, MD Medical Oncology · Chicago, IL
- Shirish M. Gadgeel, MD Medical Oncology · Detroit, MI
- Konstantinos Leventakos, M.D. Medical Oncology · Rochester, MN
- Andrew S. Dothard, M.D. Medical Oncology · Winston Salem, NC
- Konstantin H. Dragnev, MD Hematology & Oncology · Lebanon, NH
- Bruno S. Fang, MD Hematology & Oncology · East Brunswick, NJ
- Martin E. Gutierrez, MD Medical Oncology · Hackensack, NJ
- Benjamin O. Herzberg, MD Medical Oncology · New York, NY
- Salman Punekar, M.D. Medical Oncology · New York, NY
- Charles M. Rudin, M.D., PH.D. Hematology & Oncology · New York, NY
- Rajwanth Veluswamy, MD Medical Oncology · New York, NY
- Balazs Halmos, MD Hematology & Oncology · Cleveland, OH
- Tony V. Ho, MD Hematology & Oncology · Portland, OR
- Melina E. Marmarelis, M.D. Internal Medicine · Philadelphia, PA
- Melissa L. Johnson, MD Medical Oncology · Nashville, TN
- Mohamad A. Salkeni, M.D. Hematology & Oncology · Fairfax, VA
- Jonathan Thompson, M.D. Hematology & Oncology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Northshore University Healthsystem - Evanston Hospital, IL $420,219
- New York University $352,364
- Next Oncology-San Antonio $232,687
- Hackensack University Medical Center, NJ $176,002
- Medical College of Wisconsin $168,272
- Sarah Cannon Research Institute $163,495
- Regents of the University of Minnesota $150,338
- Titan Health PArtners, Llc $116,899
- Adventhealth Orlando, FL $109,116
- Moffitt Cancer Center $68,934
- Biomedical Research Alliance of New York LLC $67,072
- Henry Ford Health Hospital, MI $42,250
- Hospital of Univ of Pennsylvania, PA $40,442
- Mayo Clinic Hospital Rochester, MN $38,224
- Trustees of Columbia University in The City of New York $36,565
- David H Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center $34,819
- Mary Hitchcock Memorial Hospital, NH $27,985
- Hoag Hospital Newport Beach $26,039
- Thomas Jefferson University Hospital, PA $24,887
- Mayo Clinic, FL $23,959
- Mayo Clinic Hospital, AZ $23,959
- University of Alabama Hospital, AL $18,385
- Novant Health Forsyth Medical Center, NC $15,582
- NYU Langone Health Perlmutter Cancer Center $10,129
- Northwestern Memorial Hospital, IL $8,735
- Abramson Cancer Center $7,192
- Scri Oncology PArtners $5,469
- Montefiore Medical Center, NY $2,797
- Astera Cancer Care East Brunswick $2,461
- Froedtert Memorial Lutheran Hospital, WI $992
- Mayo Clinic Methodist Hospital $799
- Northwest Cancer Specialists PC Admin Office $799
- Dana-Farber Cancer Institute $306
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.