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The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Active, not recruiting · Phase 3 · NCT06383390

Conditions: Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)

At a glance

Research payments reported, 2025
$27.9M
U.S. investigators named
234
Sites paid
198
Planned or actual enrollment
10,000

About the trial

Sponsor
Eli Lilly and Company
Tested
Retatrutide (drug), Placebo (drug)
Dates
Started 2024-04-30; completion 2029-02
Results posted
Not yet

The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function. The trial will enroll adults with body mass index 27 kg/m\^2 or higher and Atherosclerotic Cardiovascular Disease and/or chronic kidney disease. The study will last for about 5 years. Participants will have up to 27 clinic visits with the study doctor.

From ClinicalTrials.gov, last updated 2026-10-08. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $27.9M in research payments for this study in 2025 (384 payments).

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Flourish Research Acquisition LLC $1.5M
  • Care Access Research LLC $1.3M
  • Elligo Health Research Inc $1.1M
  • Panoramic Science LLC $755,682
  • Biopharma Informatic Inc $652,323
  • Alliance for Multispecialty Research Lls $648,997
  • Apogee Clinical Research LLC $590,712
  • Emory University Hospital, GA $566,527
  • Southeastern Clinical Research Institute LLC $541,231
  • West Clinical Research Inc $507,779
  • Invivocure LLC $505,964
  • Tri State Medical Group Inc $483,555
  • American Research Institute Inc $475,272
  • American Clinical Trials LLC $427,880
  • Revival Research Institute LLC $415,980
  • Horizon Clinical Research Group $405,665
  • Ima Evaluations LLC DBA Ima Clinical Research $398,606
  • Omega Research Orlando LLC $393,084
  • Prx Research and Development LLC DBA Prx Research $387,051
  • New Age Medical Research Corp $351,929
  • Discovery Clinical Trials LLC $347,664
  • The University of Texas $346,730
  • Western Nephrology and Metabolic Bone Disease PC $330,611
  • Piedmont Medical Research Associates Inc $317,979
  • $296,712
  • Clinical Advancement Center PLLC $287,202
  • Qualmedica Research LLC $279,641
  • Reid Physician Associates Inc DBA Reid Health Physician Associates $262,446
  • Regents of the University of Colorado $249,259
  • Renal Disease Research Institute LLC $241,595
  • Center for Advanced Research & Education LLC $241,344
  • Biopharma Informatic Inc Research Center $238,579
  • Davita Clinical Research $238,072
  • Phoenix Clinical Trials LLC $235,768
  • Clinical Research Advantage $234,076
  • Spectrum Clinical Research Inc $232,659
  • Long Island Cardiovascular Imaging Consultants PC $230,877
  • North Georgia Clinical Research $229,303
  • Inpatient Research Clinic DBA Las PAlmas Research Center $228,769
  • Clinvest Research LLC $228,472
  • Millennium Clinical Trials LLC $222,220
  • Elixia Mkc LLC $203,530
  • Valley Institute of Research LLC $201,804
  • Sahni Rheumatology and Therapy PC $201,017
  • Advanced Clinical Research LLC $200,201
  • Cotton Oneil Msd of Stormont Vail Healthcare $183,725
  • Medrasa Clinical Research LLC $181,935
  • Jacksonville Center for Clinical Research $180,814
  • Wcr Associates LLC DBA Wellness Clinical Research $179,570
  • Endocrine Ips PLLC $178,648
  • Aqua Research Institute LLC $176,112
  • Onhealth Research Center LLC $166,423
  • Medstar Health Research Institute $161,587
  • Eastside Research Associates LLC $160,819
  • Soma Clinical Trials LLC $156,033
  • Medical University of South Carolina $154,934
  • Amzern Clinical Trials Organization $153,171
  • Nani Research LLC $152,666
  • Chase Medical Research LLC $152,059
  • Preferred Primary Care Physicians Inc $151,958
  • East Coast Institute for Research $148,922
  • Cardiology Associates of Fairfield $148,358
  • Clinical Investigation Specialists Inc $147,053
  • Ark Clinical Research LLC $146,392
  • Hb Clinical Trials Inc $139,690
  • Las Vegas Medical Research LLC $130,373
  • Capital Area Research LLC $127,735
  • Studymetrix Research LLC $125,614
  • Atlanta Diabetes Associates $121,505
  • Southern Endocrinology Associates PA $120,138
  • Sinai Hospital of Baltimore, MD $119,073
  • Encompass Clinical Research $118,854
  • Metropolitan Cardiovascular Consultants LLC $115,671
  • Neighborhood Healthcare $115,255
  • National Institute of Clinical Research $115,130
  • Accurate Clinical Research Inc $114,108
  • Providence St Mary $112,925
  • Ronald Reagan UCLA Medical Center, CA $112,193
  • Geisinger Clinic $111,937
  • Jpj Research Inc DBA Valiance Clinical Research $108,588
  • New York University $107,262
  • Medication Management LLC $104,771
  • Universal Research Group LLC $102,547
  • Louisville Metabolic $101,305
  • Palm Harbor Drmtlgy PA $100,961
  • Irst Business Specialty Finance $99,785
  • Helios Cr, Inc. $98,555
  • Henderson Clinical Trials LLC $97,473
  • Velocity Clinical Research Inc $96,966
  • Akdhc Medical Research Services LLC $92,038
  • Gcm Medical Group Psc $90,754
  • Headlands Horizons LLC $89,730
  • Arcturus Healthcare PLC, Troy Internal $88,621
  • Elixia Central Florida LLC $86,826
  • Elite Clinical Studies LLC $85,300
  • Advanced Medical Research $84,950
  • Utah Cardiology $84,150
  • Alabama Kidney Research $82,134
  • Univ of Kansas Med Cntr Rsrch Institute $80,301
  • St Vincent Hospital, WI $80,195

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.