A Study to Assess BOTOX Injections in Adult Participants for the Change of Masseter Muscle Prominence
Completed · Phase 3 · NCT06387394
Conditions: Masseter Muscle Prominence
At a glance
- Research payments reported, 2025
- $1.8M
- U.S. investigators named
- 21
- Sites paid
- 29
- Planned or actual enrollment
- 202
About the trial
- Sponsor
- AbbVie
- Tested
- BOTOX (drug), Placebo (drug)
- Dates
- Started 2024-04-22; completion 2025-11-25
- Results posted
- Not yet
The masseter muscle is one of the muscles in the lower face used for chewing. The prominence of the masseter muscle can appear as a widened lower face which some individuals deem as aesthetically undesirable and can be treated by selectively weakening the masseter muscles with small quantities of botulinum toxin. The purpose of this study is to assess how safe and effective injection of onabotulinumtoxinA (BOTOX) is in adult participants with Masseter Muscle Prominence (MMP). BOTOX is being investigated for the treatment of Muscle Masseter Prominence. In Period 1, participants are placed in 1 of 2 groups, called treatment arms. Each group receives a different treatment, placebo or BOTOX. …
From ClinicalTrials.gov, last updated 2026-08-25. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $1.8M in research payments for this study in 2025 (235 payments).
Products named: Botox
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Melanie L. Appell, MD Dermatology · Birmingham, AL
- Lisa D. Grunebaum, MD ENT (Otolaryngology) · Scottsdale, AZ
- Brittany E. Howard, M.D. ENT (Otolaryngology) · Scottsdale, AZ
- Sabrina G. Fabi, M.D. Dermatology · San Diego, CA
- Derek H. Jones, MD Dermatology · Los Angeles, CA
- Ava T. Shamban, MD Dermatology · Santa Monica, CA
- Deanne Mraz, MD Dermatology · Westport, CT
- Terrence C. Keaney, M.D Dermatology · Washington, DC
- Susan H. Weinkle, M.D. Specialist · Bradenton, FL
- Heather C. Woolery-lloyd, MD Dermatology · Miami, FL
- William P. Coleman III, M.D. Dermatology · Metairie, LA
- Deirdre Hooper, M.D. Dermatology · New Orleans, LA
- Wendy L. Mcfalda, D.O. Dermatology · Clarkston, MI
- Rosalyn George, M.D. Dermatology · Wilmington, NC
- David J. Goldberg, M.D Mohs Surgery · Hackensack, NJ
- Keimun A. Slaughter, M.D. Facial Plastic Surgery · Latham, NY
- Jennifer L. Nash, M.D. Dermatology · Westerville, OH
- Michael H. Gold, M.D. Specialist · Nashville, TN
- Edward L. Lain, M.D. Dermatology · Austin, TX
- Rodney J. Rohrich, MD Plastic Surgery · Dallas, TX
- Craig F. Teller, M.D. Dermatology · Bellaire, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Cr Services Acquisition US LLC $162,001
- Skin Dc PLLC $157,570
- Rod J Rohrich MD PA $137,651
- Tennessee Clinical Research Center $124,268
- Ava T Shamban MD Inc $117,711
- Dmr Research PLLC $101,569
- Dermatologycosmetic Laser Medical $99,338
- Pflugerville Dermatology Clinical $89,022
- Susan H Weinkle MD $80,501
- Edwin F Williams III MD $78,795
- William P Coleman III MD $78,101
- Bellaire Dermatology Associates $70,093
- Schweiger Dermatology PC $69,632
- Delricht LLC $69,488
- Skin & Cancer Associates LLP $65,978
- Wdc Cosmetic and Research PLLC $61,296
- Michigan Center for Research $50,180
- Mayo Clinic Hospital, AZ $41,481
- Total Skin & Beauty Dermatology Cen $18,785
- Dermatology Management LLC $17,682
- Bellaire Dermatology $10,083
- William P Coleman III MD A Professional Medical Corporation $10,083
- Cr Services Acquisition US $10,083
- Total Skin and Beauty Dermatology Center $10,083
- The Rejuva Center at Williams $10,083
- Skin and Cancer Associates LLP $9,243
- $8,000
- Tennessee Clinical Research Center LLC $917
- Delricht Research at Touro Medical Center $917
- Michigan Center for Research Corporation $917
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.