A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab
Active, not recruiting · Phase 3 · NCT06389136
Conditions: Atopic Dermatitis
At a glance
- Research payments reported, 2025
- $1.4M
- U.S. investigators named
- 58
- Sites paid
- 58
- Planned or actual enrollment
- 184
About the trial
- Sponsor
- AbbVie
- Tested
- Upadacitinib 15mg Dose (drug), Dupilumab 300mg Dose (drug), Upadacitinib 30mg Dose (drug)
- Dates
- Started 2024-06-14; completion 2027-05
- Results posted
- Not yet
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study aims to provide data on the efficacy and safety of upadacitinib at different doses in adult participants with moderate to severe AD. Upadacitinib is an approved drug for the treatment of moderate to severe atopic dermatitis (AD). This study is conducted in 2 periods. During Period 1, participants are randomly assigned into 1 of 2 groups called treatment arms to receive upadacitinib 15mg or dupilumab 300mg. Based on the participants r…
From ClinicalTrials.gov, last updated 2026-10-16. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $1.4M in research payments for this study in 2025 (342 payments).
Products named: Rinvoq
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Warner W. Carr, MD Allergy & Immunology · Laguna Niguel, CA
- Albert Chiou, MD Dermatology · Stanford, CA
- Alina Goldenberg, MD Dermatology · Oceanside, CA
- Tooraj J. Raoof, MD Internal Medicine · Encino, CA
- Raja Sivamani, M.D., M.S., A.H.E. Dermatology · Sacramento, CA
- Christopher G. Bunick, M.D., PH.D. Dermatology · New Haven, CT
- Wanda M. Boote, MD Dermatology · St Petersburg, FL
- Christopher D. Ewanowski, M.D. Dermatology · Lutz, FL
- Kristin Haushalter, MD Dermatology · Miami, FL
- Pearl C. Kwong, MD PHD Dermatology · Jacksonville, FL
- Stephen J. Lockwood, MD Dermatology · Brandon, FL
- Luis T. Menendez, M.D. Dermatology · Tampa, FL
- John Niven, M.D. Dermatology · Miami Beach, FL
- Ann M. Reed, D.O. Dermatology · Boca Raton, FL
- David Rodriguez, ARNP, NP-C Nurse Practitioners · Hialeah, FL
- Michael A. Scannon, M.D. Dermatology · Tampa, FL
- Tory Sullivan, M.D. Dermatology · North Miami Beach, FL
- Eduardo T. Weiss, MD Dermatology · Hollywood, FL
- Nathan J. Cleaver, DO Dermatology · Cumming, GA
- Joshua E. Lane, M.D. Mohs Surgery · Columbus, GA
- Sidney P. Smith, M.D Mohs Surgery · Savannah, GA
- George M. Lewitt, M.D. Dermatology · Northbrook, IL
- Walter Liszewski, MD Dermatology · Chicago, IL
- Scott A. Fretzin, M.D. Dermatology · Indianapolis, IN
- Cindy E. Owen, M.D. Dermatology · Louisville, KY
- Mary M. Dobson, MD Dermatology · Baton Rouge, LA
- Victoria Kuohung, MD Dermatology · Quincy, MA
- John Leung, M.D. Gastroenterology · Boston, MA
- Martina Porter, MD Dermatology · Boston, MA
- Suresh Anne, MD Allergy & Immunology · Flint, MI
- Linda F. Stein Gold, M.D. Dermatology · West Bloomfield, MI
- Neetu Talreja, MD Hospitalist · Detroit, MI
- Nicole M. Seminara, M.D. Dermatology · Huntersville, NC
- Rex F. Largen, MD Dermatology · Lincoln, NE
- Joel Schlessinger, M.D Dermatology · Omaha, NE
- Irene H. Mannering, M.D. Dermatology · Sparks, NV
- Andrew Alexis, MD Dermatology · New York, NY
- Michael C. Cameron Dermatology · New York, NY
- Eric L. Simpson, MD Dermatology · Portland, OR
- Jason M. Schoenfeld, M.D. Mohs Surgery · Philadelphia, PA
- Joe K. Tung, MD, MBA Dermatology · Pittsburgh, PA
- Jonathan T. Wolfe, MD Dermatology · Plymouth Meeting, PA
- Carmen Colon-tarbal, M.D. Pediatrics · San Juan, PR
- Alma M. Cruz Santana, MD Dermatology · Carolina, PR
- Eneida M. De La Torre - Lugo, M.D. Dermatology · Bayamon, PR
- Jose R. Gonzalez Chavez, M.D. Dermatology · Santurce, PR
- Samuel Sanchez Rivera, MD Dermatology · Caguas, PR
- Amylynne J. Frankel, M.D. Dermatology · Spartanburg, SC
- Lara Wine Lee, M.D. Dermatology · Charleston, SC
- Lauren S. Campbell, M.D. Dermatology · Cypress, TX
- Jennifer C. Cather, M.D. Dermatology · Dallas, TX
- Jennifer D. Holman, MD Dermatology · Tyler, TX
- William C. Howland III, MD Allergy & Immunology · Austin, TX
- Angela Y. Moore, MD, PA Dermatopathology · Arlington, TX
- So Yeon Paek, M.D. Dermatology · Dallas, TX
- Ross C. Radusky, M.D. Dermatology · Dallas, TX
- Craig F. Teller, M.D. Dermatology · Bellaire, TX
- Rola M. Gharib, M.D. Dermatology · Morgantown, WV
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Skin Care Research Inc $147,199
- Equity Medical LLC $100,601
- Integrative Skin Science $88,754
- Onyx Clinical Research LLC $77,201
- Advanced Dermatology of Sc PC $61,976
- International Derm Research Inc $59,302
- On-Site Clinical Solutions LLC $50,201
- Physician Research $50,046
- Henry Ford Health Hospital, MI $46,373
- Yale University $43,603
- Arlington Research Center Inc $40,872
- Northwestern University $40,614
- Treasure Valley Medical Research $36,542
- Dr Samuel Sanchez Psc $32,651
- Gcp Clinical Research LLC $32,496
- Boston Food Allergy Center $32,394
- Profound Research LLC $32,190
- Caribbean Medical Research Center $30,777
- Medical University South Carolina $28,038
- Weill Medical College of Cornell Un $27,375
- Ds Research of Kentucky LLC $25,578
- T Joseph Raoof MD Inc $23,140
- Alliance Clinical Research of Tampa $22,336
- Cr Services Acquisition US LLC $22,160
- Mountain West Derm-Blackhart PLLC $18,131
- Skin Specialists PC $18,035
- The Board of Trustees of the Leland $17,082
- Modern Research Associates PLLC $16,524
- Gcm Medical Group Psc $16,497
- Moore Clinical Research Inc $15,889
- Dermatology Treatment And $14,914
- University of Pittsburgh Physicians $14,540
- Studies in Dermatology LLC $13,215
- Ohsu Hospital and Clinics, OR $11,520
- Dermatology Associates of Plymouth $10,695
- Solutions Through Advanced Research $9,626
- Alma M Cruz-Santana $9,063
- Lenus Research & Medical Group $9,000
- Texas Dermatology Research Center $8,500
- Research Associates of S Flo LLC $8,400
- Beth Israel Deaconess Medical Center, MA $7,712
- Oliver Street 501 (a) Inc $7,566
- Beacon Clinical Research LLC $7,237
- Allergy & Asthma Associates Of $7,122
- Dawes Fretzin Clinical Research $6,989
- Palm Harbor Dermatology $5,916
- Apex Clinical Trials LLC $5,695
- West Virginia Research Institute $5,200
- Scb Research Center Corp $5,000
- Velocity Clinical Research Inc $4,600
- Cleaver Medical Group Dermatology $3,813
- Denova Research $2,990
- Bellaire Dermatology Associates $2,947
- Howland Allergy & Asthma PLLC $2,168
- Clinical Research Philadelphia LLC $1,135
- Elligo Health Research Inc $1,083
- Dermatology Associate of Plymouth Meeting PC $474
- Ziaderm Research LLC $200
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.