A Study to Assess BOTOX Injections for the Change of Masseter Muscle Prominence in Adult Participants
Completed · Phase 3 · NCT06399718
Conditions: Masseter Muscle Prominence
At a glance
- Research payments reported, 2025
- $1.6M
- U.S. investigators named
- 20
- Sites paid
- 34
- Planned or actual enrollment
- 207
About the trial
- Sponsor
- AbbVie
- Tested
- BOTOX (drug), Placebo (drug)
- Dates
- Started 2024-04-30; completion 2025-11-10
- Results posted
- Not yet
The masseter muscle is one of the muscles in the lower face used for chewing. The prominence of the masseter muscle can appear as a widened lower face which some individuals deem as aesthetically undesirable and can be treated by selectively weakening the masseter muscles with small quantities of botulinum toxin. The purpose of this study is to assess how safe and effective injection of onabotulinumtoxinA (BOTOX) is in adult participants with Masseter Muscle Prominence (MMP). BOTOX is being investigated for the treatment of Muscle Masseter Prominence. In Period 1, participants are placed in 1 of 2 groups, called treatment arms. Each group receives a different treatment, placebo or BOTOX. …
From ClinicalTrials.gov, last updated 2026-08-12. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $1.6M in research payments for this study in 2025 (177 payments).
Products named: Botox
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Amir Moradi, MD ENT (Otolaryngology) · Vista, CA
- Alexander Rivkin, MD Family Medicine · Los Angeles, CA
- Steve G. Yoelin, MD Optometrists · Newport Beach, CA
- Lisa M. Donofrio, M.D. Dermatology · New Haven, CT
- Noelle S. Sherber, M.D. Dermatology · Washington, DC
- Steven Fagien, M.D. General Surgery · Boca Raton, FL
- Jeremy B. Green, M.D. Dermatology · Coral Gables, FL
- Carmen M. Kavali, MD Plastic Surgery · Atlanta, GA
- Steven H. Dayan, M.D. Plastic Surgery · Chicago, IL
- Ira H. Thorla JR., M.D. Dermatology · Baton Rouge, LA
- Ira D. Papel, MD Facial Plastic Surgery · Baltimore, MD
- Mary G. Veremis-ley, DO Dermatology · Clinton Township, MI
- Joel Schlessinger, M.D Dermatology · Omaha, NE
- Roy G. Geronemus, M.D. Specialist · New York, NY
- Sachin M. Shridharani, M.D. Plastic Surgery · New York, NY
- Brian S. Biesman, M.D. Specialist · Nashville, TN
- Deborah D. Sherman, MD Ophthalmology · Nashville, TN
- David A. Bushore, M.D. Dermatology · Austin, TX
- Megan P. Couvillion, MD Dermatology · Houston, TX
- Daniel P. Friedmann, M.D. Dermatology · Austin, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Steve Yoelin Medical Associates Inc $179,653
- Luxurgery LLC $127,255
- Pflugerville Dermatology Clinical $109,837
- Carmen Michelle Kavali MD PC $105,844
- Westlake Dermatology PA $100,214
- Steven Fagien MD $98,606
- Skin Specialists PC $91,742
- Midwest Center for Dermatology And $89,706
- Denova Research $86,361
- The Prct of Brian Sbiesmanmdpllc $84,641
- Skin Research Institute LLC $78,987
- Facial Plastic Surgicenter LTD $74,050
- Etrecosmetic Derm & Laser Ctr LLC $68,647
- Noelle Starr Sherber MD LLC $64,282
- Delricht LLC $54,015
- Alexander Rivkin MD Inc $53,803
- Pacific Clinical Innovations Inc $45,390
- Dermresearch PA $31,862
- Kavali Plastic Surgery and Skin Renewal Center $10,083
- Steve Yoelin MD Medical Associates Inc $10,083
- Westlake Dermatology and Cosmetic Surgery $10,083
- Midwest Center for Dermatology and PAthology PLLC $10,083
- Steven Fagien MD PA $10,083
- Delricht Research at Touro Medical Center $10,083
- Arano LLC $10,083
- Sherman Aesthetic Center $3,361
- Laser and Skin Surgery Center of New York $1,681
- Deborah D Sherman $1,000
- Skin Specialist PC $917
- Westside Aesthetics $917
- Etre Cosmetic Dermatology and Laser Center $917
- Luxurgery Nyc $917
- Brian S Biesman MD Facs $917
- Dermresearch $917
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.