SIMPLAAFY Clinical Trial
Active, not recruiting · Not applicable · NCT06521463
Conditions: Atrial Fibrillation, Stroke, Bleeding
At a glance
- Research payments reported, 2025
- $6.8M
- U.S. investigators named
- 86
- Sites paid
- 85
- Planned or actual enrollment
- 1,857
About the trial
- Sponsor
- Boston Scientific Corporation
- Tested
- WATCHMAN FLX Pro LAAC Device (device)
- Dates
- Started 2024-10-01; completion 2027-01
- Results posted
- Not yet
The primary objective is to demonstrate the safety and effectiveness of two monotherapy regimens versus dual antiplatelet (DAPT) therapy following post-implant with the WATCHMAN FLX Pro device in a commercial clinical setting.
From ClinicalTrials.gov, last updated 2026-10-13. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Boston Scientific Corporation reported $6.8M in research payments for this study in 2025 (780 payments).
Products named: Watchman Access System
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Hugh Mcelderry Cardiac Electrophysiology · Birmingham, AL
- Anil Rajendra, M.D. Cardiac Electrophysiology · Birmingham, AL
- Devi G. Nair, MD Cardiac Electrophysiology · Jonesboro, AR
- Yoaav S. Krauthammer, M.D. Cardiac Electrophysiology · Phoenix, AZ
- Ashish Sadhu, M.D. Cardiac Electrophysiology · Scottsdale, AZ
- Thomas E. Waggoner I, D.O. Interventional Cardiology · Tucson, AZ
- Joseph Aragon, M.D. Interventional Cardiology · Santa Barbara, CA
- Rahul Bhardwaj, M.D. Cardiac Electrophysiology · Loma Linda, CA
- Andrew J. Dublin, MD Interventional Cardiology · Walnut Creek, CA
- Jonathan W. Dukes, M.D. Cardiac Electrophysiology · Ventura, CA
- Matthew J. Price, M.D. Interventional Cardiology · La Jolla, CA
- Chidambaram (chad) Rammohan, M.D. Interventional Cardiology · Mountain View, CA
- Richard F. Wright, M.D. Heart Failure & Transplant Cardiology · Santa Monica, CA
- Russell R. Heath, MD Cardiac Electrophysiology · Fort Collins, CO
- Ganesh S. Venkataraman, M.D. Cardiac Electrophysiology · Lakewood, CO
- Bryan J. Piccirillo, M.D. Interventional Cardiology · Hartford, CT
- Manish H. Shah, MD Cardiac Electrophysiology · Washington, DC
- Robert E. Eckart, DO Cardiac Electrophysiology · Sarasota, FL
- Ruby Satpathy, M.D. Interventional Cardiology · Jacksonville, FL
- Dinesh Sharma, M.D. Cardiac Electrophysiology · Naples, FL
- David B. Delurgio, M.D. Cardiac Electrophysiology · Atlanta, GA
- Amar D. Patel, M.D. Interventional Cardiology · Marietta, GA
- Felix O. Sogade, M.D. Cardiac Electrophysiology · Macon, GA
- Rayji S. Tsutsui, MBCHB Cardiology · Honolulu, HI
- Phillip A. Horwitz, MD Interventional Cardiology · Iowa City, IA
- Troy L. Hounshell, D.O. Cardiology · West Des Moines, IA
- Marcos Daccarett, MD Cardiac Electrophysiology · Boise, ID
- Eric L. Wallace, D.O. Interventional Cardiology · Coeur D Alene, ID
- Mark D. Metzl, MD Cardiac Electrophysiology · Evanston, IL
- Moeen A. Saleem, MD Cardiac Electrophysiology · Naperville, IL
- William H. Spear, M.D. Cardiac Electrophysiology · Evergreen Park, IL
- Kevin M. Trulock, M.D. Cardiac Electrophysiology · Indianapolis, IN
- Yeruva Veera Madhu M. Reddy, MD Cardiac Electrophysiology · Kansas City, KS
- Kent E. Morris, MD Cardiac Electrophysiology · Louisville, KY
- Gery F. Tomassoni, M.D. Cardiac Electrophysiology · Lexington, KY
- Moussa C. Mansour, MD Cardiac Electrophysiology · Boston, MA
- Adam J. Saltzman, MD Heart Failure & Transplant Cardiology · Fall River, MA
- Glenn T. Stokken, M.D. Cardiology · Worcester, MA
- Duane C. Berkompas, MD Interventional Cardiology · Grand Rapids, MI
- Jihn Han, MD Cardiac Electrophysiology · Ypsilanti, MI
- Arfaat M. Khan, M.D. Cardiology · Detroit, MI
- Stuart W. Adler II, M.D. Cardiac Electrophysiology · Saint Paul, MN
- Jacob R. Dutcher, MD Interventional Cardiology · St Cloud, MN
- Ammar M. Killu, MBBS Cardiology · Rochester, MN
- Marat Yanavitski, MD Interventional Cardiology · Saint Paul, MN
- Chetan P. Huded, MD Interventional Cardiology · Kansas City, MO
- James H. Hamilton IV, MD Cardiac Electrophysiology · Jackson, MS
- James E. Stone JR., M.D. Cardiac Electrophysiology · Tupelo, MS
- Oluseun O. Alli, MD Interventional Cardiology · Charlotte, NC
- Steven J. Filby, M.D. Interventional Cardiology · Pinehurst, NC
- Ashish B. Patel, M.D. Cardiac Electrophysiology · Raleigh, NC
- Michael J. Rinaldi, MD Cardiology · Charlotte, NC
- Willis M. Wu, MD Interventional Cardiology · Raleigh, NC
- Aaron V. Kaplan, MD Interventional Cardiology · Lebanon, NH
- Suneet Mittal, M.D. Cardiac Electrophysiology · Paramus, NJ
- Sajjad A. Sabir, M.D. Cardiology · Camden, NJ
- Darius Sholevar, MD Cardiac Electrophysiology · Cherry Hill, NJ
- Michael H. Hoskins, M.D. Cardiac Electrophysiology · Albuquerque, NM
- Larry A. Chinitz, M.D. Cardiac Electrophysiology · New York, NY
- Jason Chinitz, MD Student in an Organized Health Care Education/Training Program · New York, NY
- Christine Chung, M.D. Vascular Surgery · Mineola, NY
- Luigi Di Biase, MD, PHD Cardiology · Bronx, NY
- Vijay S. Iyer, MD, PHD Cardiology · Amherst, NY
- Mohit K. Turagam, M.D Cardiac Electrophysiology · New York, NY
- Gaurang D. Gandhi, MD FACC Cardiac Electrophysiology · Cincinnati, OH
- Mahmoud Houmsse, MD Cardiac Electrophysiology · Dublin, OH
- P K. Ramanathan, MD Interventional Cardiology · Toledo, OH
- Walid I. Saliba, MD Cardiac Electrophysiology · Cleveland, OH
- Amish J. Desai, MD Interventional Cardiology · Portland, OR
- Chinmay P. Patel, MD Cardiology · Lancaster, PA
- Frank A. Cuoco JR., MD Cardiac Electrophysiology · Charleston, SC
- Patrick A. Hall, MD Interventional Cardiology · Columbia, SC
- Loren G. Morgan, MD Interventional Cardiology · Columbia, SC
- Todd N. Senn, MD Cardiac Electrophysiology · Columbia, SC
- Eric E. Johnson, MD Cardiac Electrophysiology · Memphis, TN
- Robert A. Pickett, M.D. Cardiac Electrophysiology · Nashville, TN
- Karan S. Bhalla, MD Cardiology · Pasadena, TX
- Amir Kashani, MD, MS Interventional Cardiology · Houston, TX
- Andrea Natale, MD Cardiac Electrophysiology · Austin, TX
- Stanislav Weiner, MD Cardiac Electrophysiology · Longview, TX
- Jason Foerst, M.D. Interventional Cardiology · Roanoke, VA
- Venkat R. Iyer, M.D. Cardiac Electrophysiology · Chesapeake, VA
- Maheer Gandhavadi Cardiac Electrophysiology · Bellevue, WA
- Marcie G. Berger, M.D. Cardiac Electrophysiology · Milwaukee, WI
- Rudolph F. Evonich III, M.D. Cardiac Electrophysiology · Green Bay, WI
- Wissam Gharib, M. D. Interventional Cardiology · Morgantown, WV
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Nair Research LLC $435,035
- HCA Research Institute LLC $368,309
- Bellin Memorial Hospital $361,488
- Tmc Healthcare $338,351
- Christus Trinity Mother Frances Health System $312,197
- John Muir Medical Center - Walnut Creek Campus, CA $262,632
- Trihealth Inc $239,951
- Ahp Health PArtners Inc $232,694
- Emory University Hospital, GA $205,670
- Colorado Heart and Vascular PC $177,658
- Wake Forest University $174,284
- University of Kansas Medical Center Research Institute Inc $162,373
- Cardiology Associates Medical Group $144,912
- St Lukes Hospital of Kansas City, MO $144,732
- Phoenix Cardiovascular Research Group $144,074
- Sentara Health $144,069
- Saint Thomas Health $124,340
- Community Hospital East, IN $124,117
- Virtua Health Inc $123,371
- Nc Heart and Vascular Research LLC $120,347
- Sarasota Memorial Hospital, FL $110,702
- Affinity Cardiovascular Specialists LLC $105,014
- Wellstar Health System $104,567
- Baptist Health Lexington, KY $92,151
- Honor Health John C. Lincoln Medical Center, AZ $85,370
- Cardiology Associates Research LLC $80,391
- Mayo Clinic $79,506
- Carilion Medical Center, VA $78,683
- Stern Cardiovascular Foundation Inc $69,105
- Baptist Health Ambulatory Services Inc $65,021
- West Houston Area Clinical Trial Consultants LLC $59,825
- Medical Center of the Rockies $56,049
- Santa Barbara Cottage Hospital, CA $54,876
- St Luke's Regional Medical Center, ID $53,835
- Uh Cleveland Medical Center, OH $53,158
- University of Massachusetts $50,545
- Dartmouth Hitchcock Clinic $49,368
- The Medical College of Wisconsin Inc. $47,842
- M Health Fairview University of Mn Medical Center, MN $45,372
- Aurora Research Institute LLC $44,415
- Mercyone Des Moines Medical Center, IA $41,693
- Scripps Mercy Hospital, CA $41,087
- Biomedical Research Alliance of New York $40,942
- University of Alabama Hospital, AL $40,412
- Cis Clincal Research Corporation $38,879
- The Valley Hospital Inc $37,729
- Novant Health Inc $37,255
- Henry Ford Health Hospital, MI $35,045
- Pinnaclehealth Cardiovascular Institute $33,970
- Karan Bhalla MD PLLC $32,146
- Northshore University Healthsystem - Evanston Hospital, IL $31,823
- The Research Foundation of Syny $31,762
- The Feinstein Institute for Medical Research $31,542
- Southcoast Hospitals Group Inc $31,507
- Centracare - St. Cloud Hospital, MN $31,359
- The Ohio State University $29,931
- Legacy Emanuel Medical Center, OR $29,523
- King County Public Hospital District No 2 $28,240
- Loma Linda University Adventist Health Sciences Center $26,947
- Georgia Arrhythmia Consultants and Research Institute $26,931
- Medstar Health Research Institute $26,793
- Corewell Health $26,462
- University of Washington Medical Ctr, WA $25,137
- Cedars-Sinai Medical Center, CA $25,005
- New York University $23,945
- Hartford Hospital, CT $22,404
- Wakemed, Raleigh Campus, NC $21,493
- Massachusetts General Hospital, MA $21,000
- Trinity Health-Michigan $19,795
- Promedica Toledo Hospital, OH $18,794
- Musc Medical Center, SC $18,451
- Norton Healthcare Incorporated $18,229
- Hawaii PAcific Health $17,904
- Hti Hospital Holdings Inc $17,268
- Cleveland Clinic, OH $17,085
- Texas Cardiac Arrythmia Research $14,402
- Nch Healthcare System Inc $14,027
- Icahn School of Medicine at Mount Sinai $13,800
- Monongalia County General Hospital Company $12,296
- Prisma Health Richland Hospital, SC $9,005
- Kootenai Health, ID $8,684
- University of Mississippi Med Center, MS $7,370
- University of Iowa Hospital & Clinics, IA $6,890
- Cooper University Hospital, NJ $2,908
- California PAcific Medical Ctr-Davies Campus Hosp, CA $2,599
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.