Double-blind, Randomized, Placebo-controlled Study Evaluating Efficacy and Safety of IgPro20 in Post-COVID-19 POTS
Terminated · Phase 3 · NCT06524739
Conditions: Post-COVID Postural Orthostatic Tachycardia Syndrome
At a glance
- Research payments reported, 2025
- $4.1M
- U.S. investigators named
- 25
- Sites paid
- 21
- Planned or actual enrollment
- 16
About the trial
- Sponsor
- CSL Behring
- Tested
- IgPro20 (biological), Placebo (biological)
- Dates
- Started 2024-08-28; completion 2025-07-11
- Results posted
- Yes
This is a prospective, phase 3, multicenter, double-blind, randomized placebo-controlled study to investigate the efficacy, safety, and pharmacokinetics (PK) of repeat doses of IgPro20 in participants with post SARS-CoV-2 infection 2019 postural orthostatic tachycardia syndrome (post-Coronavirus Disease 2019 \[COVID-19\] POTS \[post-COVID-POTS\]).
From ClinicalTrials.gov, last updated 2026-04-13. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Csl Behring reported $4.1M in research payments for this study in 2025 (499 payments).
Products named: Hizentra
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Gerald S. Greer, MD Cardiac Electrophysiology · Little Rock, AR
- Mohamed Kazamel, MD Neurology · Scottsdale, AZ
- David S. Saperstein, MD Neurology · Scottsdale, AZ
- Jeffrey Mullen, MD Physical Medicine & Rehabilitation (PM&R) · Orange, CA
- Pam R. Taub, MD Cardiology · La Jolla, CA
- Jinny Tavee, MD Neurology · Denver, CO
- Paul S. Bradley, MD Internal Medicine · Savannah, GA
- Paul A. Lelorier, MD Cardiac Electrophysiology · New Orleans, LA
- Scott P. Striplin, M.D. OB-GYN (Obstetrics & Gynecology) · Covington, LA
- Aaref Badshah, M.D. Cardiac Electrophysiology · Bloomfield Hills, MI
- Jay R. Meyer, MD Emergency Medicine · Lincoln, NE
- Svetlana Blitshteyn, M.D. Neurology · Williamsville, NY
- Mark Gudesblatt, M.D. Neurology · Islip, NY
- Todd B. Mendelson, MD Cardiac Electrophysiology · Philadelphia, PA
- Joseph A. Boscia III, MD Pulmonology · Spartanburg, SC
- Amanda Peltier, MD Physical Medicine & Rehabilitation (PM&R) · Nashville, TN
- Surendra S. Barshikar, M.D. Physical Medicine & Rehabilitation (PM&R) · Dallas, TX
- Ratna K. Bhavaraju-sanka, M.D Physical Medicine & Rehabilitation (PM&R) · San Antonio, TX
- Esther Melamed, MD PHD Neurology · Austin, TX
- Amer Suleman, M. D. Cardiac Electrophysiology · Mckinney, TX
- Douglas H. Jones, M.D. Allergy & Immunology · Murray, UT
- Brayden P. Yellman, M.D. Rheumatology · Murray, UT
- Kamal R. Chemali, M.D. Neurology · Norfolk, VA
- Thomas A. Piscitelli, D.O. Internal Medicine · North Prince George, VA
- Thomas C. Chelimsky, MD Neurology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Metrodora Institute LLC $865,514
- University of Texas at Austin $571,370
- Velocity Clinical Research, Inc. $526,570
- Bateman Horne Center of Excellence $451,657
- Upstate Clinical Research Associates $384,576
- Uh Cleveland Medical Center, OH $315,032
- Sunbeam Clinical Research $206,386
- Arkansas Cardiology, P.a. $191,762
- National Jewish Health, CO $166,982
- Vanderbilt University Medical Center, TN $74,818
- Regents of the University of California San Diego $50,222
- University of Alabama Hospital, AL $47,158
- Uci Health-Orange, CA $46,476
- Virginia Commonwealth University Health System Medical Center $31,268
- The University of Texas Health $29,047
- Hospital of Univ of Pennsylvania, PA $28,842
- Louisiana State University Health Sciences Center New Orleans $27,722
- The University of Texas Southwestern Medical Center at Dallas $25,719
- Center for Complex Neurology $24,610
- Profound Research $17,850
- NYU Langone South Shore Neurologic Associates $259
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.