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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

Recruiting · Phase 3 · NCT06541704

Conditions: Age-related Macular Degeneration (AMD), Geographic Atrophy (GA)

At a glance

Research payments reported, 2025
$4.0M
U.S. investigators named
124
Sites paid
105
Planned or actual enrollment
975

About the trial

Sponsor
Regeneron Pharmaceuticals
Tested
Pozelimab (drug), Cemdisiran (drug), Placebo (drug)
Dates
Started 2024-10-30; completion 2033-04-09
Results posted
Not yet

This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead). The purpose of this study is to evaluate the progression rate of Geographic Atrophy in eyes of patients treated with cemdisiran alone or in combination with pozelimab compared to those treated with placebo. The study is looking at several other research questions, including: * What side effects may happen from taking the study dr…

From ClinicalTrials.gov, last updated 2026-11-05. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Regeneron Pharmaceuticals, Inc. reported $4.0M in research payments for this study in 2025 (4,360 payments).

Products named: Veopoz

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Florida Retina Institute $256,851
  • Retina Consultants of Texas $197,681
  • Colorado Retina Associates PC $193,728
  • Retinal Consultants Medical Group Inc $170,267
  • Retina Group Inc $167,454
  • University Retina and Macula Associates PC $112,709
  • Austin Retina Associates $106,265
  • Southwest Retina Research Center $95,400
  • Pautler Cohen Findlay and Eichenbaum MDs PA $83,588
  • Erie Retina Research LLC $82,795
  • Southeast Retina Center PC $73,912
  • Retina Research Institute LLC $69,396
  • $68,478
  • Retina Associates of Utah PC $67,074
  • Total Practice Management $66,800
  • Macula Retina Vitreous Research Institute $62,597
  • Retina Vitreous Consultants LLP $60,920
  • Nvision Austin Clinical Research Mso LLC $60,074
  • Tennessee Retina PC $55,427
  • Advanced Vision Research Institute $51,972
  • Mid Atlantic Retina Specialists $50,569
  • Retina Vitreous Center PLLC $48,521
  • Midwest Retina Inc $48,286
  • Retinal Research Institute LLC $45,923
  • Western Carolina Clinical Research LLC $44,697
  • Eyehealth Northwest PC $43,828
  • Ophthalmic Consultants of Boston $43,094
  • University of Chicago $41,191
  • Retina Consultants of Southern Colorado PC $39,867
  • Retina Center of Texas $39,085
  • Retina Care Specialists PLLC $36,289
  • Retina Group of New England PC $35,359
  • Piedmont Eye Center Inc $35,147
  • Eye Centers of North Texas PLLC $34,800
  • Carson Mcbeath and Boswell Inc $34,623
  • Uci Health - Fountain Valley, CA $34,455
  • Retina Associates PA $34,218
  • Mid Atlantic Retina $33,550
  • Cumberland Valley Retina Consultants PC $32,255
  • Star Vision Consultants PLLC $31,506
  • The University of Texas Southwestern Medical Center at Dallas $31,485
  • The Clinical Trials Network Ctnx $31,450
  • University of South Florida $31,300
  • California Eye Specialists Medical Group Inc $28,936
  • National Ophthalmic Research Institute $28,620
  • Florida Retina Consultants $28,615
  • Rainbow Babies and Childrens Hospital, OH $28,420
  • Clinical Trials Management LLC $28,390
  • Retina Foundation of the Southwest $27,956
  • Verum Research LLC $27,502
  • Cincinnati Eye Institute $27,487
  • Retina Research Institute $25,126
  • University of Miami $25,008
  • Illinois Retina Associates PLLC $24,977
  • Doctrials LLC $23,685
  • Texas Retina Associates $23,290
  • Deep Blue Retina Clinical Research PLLC $22,579
  • Massachusetts Eye and Ear Infirmary -, MA $22,185
  • Retina Associates PC $22,160
  • The Retina PArtners $21,866
  • Springfield Clinic LLP $21,702
  • Ochsner Medical Center Acute, LA $21,500
  • Regents of the University of Colorado $20,512
  • Retina Associates of South Texas PA $20,007
  • Tufts Medical Center, MA $19,998
  • University of California Davis Medical Center, CA $19,800
  • Georgia Retina P C $18,711
  • University of New Mexico $17,755
  • Orange County Retina Group $16,868
  • Blue Ocean Clinical Research Center LLC $16,659
  • Barnet Dulaney Perkins Eye Center $15,636
  • Vanderbilt University Medical Center, TN $15,312
  • Retina Vitreo US Consultants LLP $14,660
  • Retina Associates New Orleans $14,505
  • Retina Center of Arkansas PLLC $14,448
  • Retina Consultants of Carolina PA $14,205
  • American Institute of Research $14,200
  • Black Hills Regional Eye Institute LLP $13,855
  • Regents of the University of California $13,833
  • Retina Northwest PC $13,682
  • Salehi Retina Institute $13,562
  • Medical Center Ophthalmology Associates $13,305
  • The Ohio State University $13,190
  • Charleston Neuroscience Institute LLC $12,927
  • Austin Clinical Research LLC $12,812
  • Visionaire Products Inc $12,599
  • Southern California Permanente Medical Group $12,100
  • California Retina Consultants $11,955
  • Cascade Medical Research Institute LLC $11,855
  • Retina Consultants of Alabama $11,000
  • Retina Vitreous Associates Medical Group $10,933
  • Palmetto Retina Center LLC $10,868
  • Vitreous and Retina Consultants PA $10,840
  • Retina Macula Institute of Arizona $10,634
  • Spokane Eye Clinical Research $10,250
  • Retina PArtners of Northwest Arkansas PLLC $9,855
  • Tulsa Retina Consultants PLLC $9,855
  • Sight Medical Doctors PLLC $9,855
  • Retina Research Institute of Texas $9,855
  • University of Illinois Hospital and Clinics, IL $7,793

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.