A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 2
Completed · Phase 2 · NCT06555783
Conditions: Narcolepsy Type 2
At a glance
- Research payments reported, 2025
- $3.8M
- U.S. investigators named
- 39
- Sites paid
- 39
- Planned or actual enrollment
- 93
About the trial
- Sponsor
- Alkermes, Inc.
- Tested
- ALKS 2680 (drug), Placebo (drug)
- Dates
- Started 2024-07-26; completion 2025-11-21
- Results posted
- Not yet
The purpose of this study is to measure the safety and decrease in sleepiness in subjects with narcolepsy type 2 (NT2) when taking ALKS 2680 tablets compared to placebo tablets.
From ClinicalTrials.gov, last updated 2026-02-27. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Alkermes, Inc. reported $3.8M in research payments for this study in 2025 (2,861 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Robert C. Doekel JR., M.D. Sleep Medicine · Birmingham, AL
- Paul E. Wylie, M.D. Psychiatry · Little Rock, AR
- Chad M. Ruoff, M.D. Sleep Medicine · Scottsdale, AZ
- Emmanuel J. Mignot, M.D Sleep Medicine · Stanford, CA
- Daniel Norman, M.D. Sleep Medicine · Los Angeles, CA
- Andrew O. Schreiber, MD Neurosurgery · Santa Ana, CA
- Stephen P. Duntley, MD Sleep Medicine · Aurora, CO
- Faisal A. Fakih, MD Specialist · Winter Park, FL
- Daniel G. Lorch, M.D. Pulmonology · Brandon, FL
- Edward Mezerhane, MD Sleep Medicine · Miami, FL
- Dragos G. Zanchi, M.D Pulmonology · Brandon, FL
- Dennis M. Lacey, MD Neurology · Atlanta, GA
- Phillip W. Nowlin, MD Family Medicine · Carrollton, GA
- Charles C. Wells, M.D. Sleep Medicine · Macon, GA
- Patrick E. Whitten, M.D. Pulmonology · Peoria, IL
- James P. Maynard, M.D. Neurology · Fort Thomas, KY
- Vishal Saini, M.D. Sleep Medicine · Saginaw, MI
- Rahul B. Sangal, M.D. Sleep Medicine · Bloomfield Hills, MI
- Ruth M. Benca, MD PHD Psychiatry · Winston Salem, NC
- Daniel T. Garber, M.D. Sleep Medicine · Concord, NC
- Andrew Krystal, M.D. Psychiatry · Durham, NC
- Thomas P. Stern, M.D. Pulmonology · Huntersville, NC
- Kevin J. Reichmuth, M.D. Pulmonology · Lincoln, NE
- Matthew J. Davis, MD Neurology · Middletown, NJ
- Alec B. Platt, M.D Pulmonology · Schenectody, NY
- Bruce C. Corser, MD Pulmonology · Cincinnati, OH
- Ryan S. Drake, DO Neurology · Canton, OH
- Nancy R. Foldvary-schaefer, DO Sleep Medicine · Cleveland, OH
- Zhanna Fast, MD Internal Medicine · Philadelphia, PA
- John S. Khoury, M.D. Neurology · Abington, PA
- Anne M. Morse, DO Child Neurology · Danville, PA
- Richard K. Bogan, M.D. Pulmonology · Columbia, SC
- Joshua J. Lennon, MD Neurology · Cordova, TN
- James M. Andry, MD Sleep Medicine · San Antonio, TX
- John D. Hudson, M.D. Sleep Medicine · Austin, TX
- Gerard J. Meskill, MD Sleep Medicine · Sugar Land, TX
- Henry S. Scheuller, M.D. Sleep Medicine · Jbsa Lackland, TX
- Jerald H. Simmons, MD Sleep Medicine · Houston, TX
- David T. Plante, MD Sleep Medicine · Madison, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Tricoastal Narcolepsy and Sleep Disorders Center, PLLC. $480,974
- Clinical Neurophysiology Services PC $229,223
- Mayo Clinic Hospital, AZ $193,758
- Futuresearch Trials of Neurology, LLC. $180,510
- Sds Clinical Trials, Inc. $174,156
- Cleveland Clinic, OH $169,070
- Bogan Sleep Consultants, LLC $168,644
- Sound Asleep Research, Inc. $163,056
- The Board of Trustees of the Leland Stanford Junior University $161,763
- Teradan Clinical Trials $148,607
- Research Carolina Elite, LLC. $143,049
- Osf Heart of Mary Medical Center, IL $129,229
- Intrepid Research, LLC. $128,164
- UCSF Langley Porter Psychiatric Hospital and Clinics, CA $112,818
- Advanced Respiratory and Sleep Medicine, PLLC $90,130
- Santa Monica Clinical Trials $83,072
- Community Research Management Associates, Inc. $79,639
- Patient First MD $75,113
- Clinical Research Institute $73,409
- Delta Waves Sleep Disorders and Research Center $72,979
- Sleep Practitioners, LLC $71,120
- Respiratory Specialists $67,658
- Neuroscience Research Center, LLC. $66,879
- Thomas Jefferson University $64,256
- Comprehensive Sleep Medicine Associates Csma $64,152
- Sleep Therapy & Research Center $57,040
- University of Colorado Denver Hospital $54,244
- Preferred Research PArtners $53,786
- The Board of Regents of the University of Wisconsin System $51,952
- Neurotrials Research, Inc. $46,538
- Geisinger Clinic $30,721
- Clinical Site PArtners, LLC. $30,517
- Pharmaseek, LLC. dba Wcg Site Network $26,744
- Abington Neurological Associates, LTD. $26,073
- Bryan Medical Center, NE $12,652
- Pharmadev Clinical Research Institute, LLC $12,135
- Neurology Clinic PC $11,617
- Comprehensive Sleep Center dba Sleep Disorders Center of Alabama $11,600
- Wake Forest University Health Sciences $10,678
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.