Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML
Active, not recruiting · Phase 3 · NCT06578247
Conditions: Leukemia
At a glance
- Research payments reported, 2025
- $3.4M
- U.S. investigators named
- 34
- Sites paid
- 52
- Planned or actual enrollment
- 700
About the trial
- Sponsor
- Daiichi Sankyo
- Tested
- Quizartinib (drug), Placebo (drug), Chemotherapy (drug)
- Dates
- Started 2024-11-19; completion 2030-06-26
- Results posted
- Not yet
This study will compare the effects of Quizartinib versus placebo in combination with chemotherapy in participants with newly diagnosed FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) negative acute myeloid leukemia (AML).
From ClinicalTrials.gov, last updated 2026-07-02. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Daiichi Sankyo Inc. reported $3.4M in research payments for this study in 2025 (3,062 payments).
Products named: Vanflyta
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Sharad Khurana, MD, MSC Hematology & Oncology · Tucson, AZ
- Wanxing Chai-ho, M.D. Hematology & Oncology · Los Angeles, CA
- Gabriel N. Mannis, MD Medical Oncology · Stanford, CA
- Amer Zeidan Hematology & Oncology · New Haven, CT
- Onyee Chan, M.D. Hematology & Oncology · Tampa, FL
- Hemant S. Murthy, M.D. Hematology & Oncology · Jacksonville, FL
- Brian Parkin, MD Hematology & Oncology · Orlando, FL
- David Swoboda, MD Hematology & Oncology · Tampa, FL
- Michael J. Hochman, MD Hematology · Atlanta, GA
- Richard Larson Hematology & Oncology · Chicago, IL
- John G. Quigley Hematology · Chicago, IL
- Ayman Qasrawi, M.D. Hematology & Oncology · Lexington, KY
- Amir T. Fathi, M.D. Hematology & Oncology · Boston, MA
- Mark Levis, M.D. Medical Oncology · Baltimore, MD
- Harry P. Erba, MD Medical Oncology · Ann Arbor, MI
- Yazan Migdady, M.D. Hematology · Wyoming, MI
- Naveen Premnath, M.D Hematology & Oncology · Minneapolis, MN
- Ramzi Abboud, MD Medical Oncology · Saint Louis, MO
- Joshua F. Zeidner, M.D. Hematology & Oncology · Chapel Hill, NC
- James K. Mccloskey II, M.D. Medical Oncology · Hackensack, NJ
- Timothy T. Ferng, M.D. Hematology & Oncology · New York, NY
- James J. Yoon, M.D. Medical Oncology · New York, NY
- Uma M. Borate, MD Hematology · Columbus, OH
- Tibor J. Kovacsovics, MD Hematology & Oncology · Portland, OR
- Elie A. Traer, MD, PHD Hematology & Oncology · Portland, OR
- Margaret T. Kasner, M.D. Hematology & Oncology · Philadelphia, PA
- Alexander E. Perl, MD Medical Oncology · Philadelphia, PA
- Stephen A. Strickland JR., MD Hematology · Nashville, TN
- Naval G. Daver, MBBS Hematology & Oncology · Houston, TX
- Diaa Osman, DO Hematology & Oncology · Austin, TX
- Shilpan S. Shah, MD Hematology & Oncology · Houston, TX
- Keri R. Maher, D.O. Medical Oncology · Richmond, VA
- Harold G. Preiksaitis, MD Gastroenterology · Spokane, WA
- Guru Subramanian Guru Murthy, M.D Hematology & Oncology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Hackensack University Medical Center, NJ $954,609
- Medical College of Wisconsin $397,755
- Dana-Farber Cancer Institute $387,344
- Tampa General Hospital, FL $294,294
- Adventhealth Orlando, FL $159,284
- Washington University $156,837
- Sarah Cannon Research Institute $149,293
- Hospital of Univ of Pennsylvania, PA $140,600
- Cleveland Clinic, OH $139,809
- Ut MD Anderson Cancer Center $99,201
- Thomas Jefferson University Hospital, PA $89,436
- University of North Carolina at Chapel Hill $72,726
- Stanford University $42,849
- Board of Trustees of the Leland Stanford Junior University $38,755
- Regents of the University of Minnesota $38,560
- Henry Ford Health Hospital, MI $37,550
- Duke University $36,716
- Ohio State University $35,259
- University of Illinois Hospital and Clinics, IL $33,674
- Moffitt Cancer Center $31,172
- The Methodist Hospital Research Institute $29,350
- University of Kentucky Research Foundation $24,200
- Yale University $6,318
- Massachusetts General Hospital, MA $5,868
- Abramson Cancer Center $3,074
- Unc Hospitals, NC $2,772
- Mcglothlin Medical Education Center, Vcu $2,119
- Scri Oncology PArtners $1,991
- City of Hope National Medical Ctr $1,836
- Houston Methodist Hospital, TX $1,836
- UCSF Helen Diller Family Comprehensive Cancer Center Mission Bay $1,836
- Colorado Blood Cancer Institute $1,836
- University of Michigan Health System, MI $1,836
- Johns Hopkins University $1,836
- Georgia Cancer Center $1,836
- Emory University Hospital, GA $1,836
- University of Arizona Cancer Center North Campus $1,836
- University of Minnesota $1,836
- David H Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center $1,836
- Duke University Hospital, NC $1,836
- St David's South Austin Medical Center, TX $1,836
- Ohsu Hospital and Clinics, OR $1,836
- Sibley Memorial Hospital, DC $1,836
- Ronald Reagan UCLA Medical Center, CA $1,767
- Northshore University Healthsystem - Evanston Hospital, IL $1,643
- Uci Health-Orange, CA $1,395
- The Board of Trustees of the Leland Stanford Junior University $1,054
- Mayo Clinic Methodist Hospital $403
- Mayo Clinic Hospital, AZ $403
- Mayo Clinic, FL $403
- Uk Healthcare Markey Cancer Center $124
- The University of Chicago $93
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.