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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

Recruiting · Phase 3 · NCT06585787

Conditions: Alzheimer Disease

At a glance

Research payments reported, 2025
$6.0M
U.S. investigators named
79
Sites paid
86
Planned or actual enrollment
406

About the trial

Sponsor
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Tested
KarXT (drug), Placebo (drug)
Dates
Started 2024-09-26; completion 2026-12-22
Results posted
Not yet

The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease (AD) with moderate to severe psychosis related to AD.

From ClinicalTrials.gov, last updated 2026-10-27. Full record, eligibility and contacts (opens in a new tab)

Industry funding

E.r. Squibb & Sons, L.l.c. reported $6.0M in research payments for this study in 2025 (124 payments).

Products named: Cobenfy

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • Elias Research Associates Llc $852,570
  • Wellness Research Center $704,488
  • Mplusm Consulting Llc $519,996
  • Angels Clinical Research Institute $405,800
  • New Gen Health and Research Group $377,414
  • Floridian Neuroscience Institute $325,659
  • My Community Research Center, Inc - 7480 Bird Rd $302,401
  • High Quality Research $273,313
  • Integrity Clinical Research $250,937
  • Medone Clinical Research $227,704
  • Future Care Solution, Llc $214,347
  • Pharmaseek $135,278
  • Homestead Associates in Research, Inc $109,061
  • Dade Research Center, Llc $103,046
  • Premier Clinical Research Institute $95,693
  • Premiere Research Institute $94,426
  • Alzheimers Memory Center Flourish Research $62,250
  • Novel Clinical Research Center, Llc $55,022
  • Agile Clinical Research Trials $48,277
  • Biology Behavioral Health $37,976
  • Anesc Research $35,681
  • Ohio State University Resear Fo $34,974
  • Epic Medical Research $34,757
  • Reliant Medical Research $34,101
  • Prospective Research Innovations, Inc $33,550
  • Progressive Medical Research $33,348
  • Neurology Associates of Ormond Beach $33,329
  • K2 Medical Research the Villages $33,099
  • Sp Research PLLC $30,000
  • Banner Casa Grande Medical Center, AZ $29,906
  • Scottsdale Clinical Trials $28,957
  • Sensible Healthcare, Llc $28,763
  • Genesis Trust Research $26,203
  • University of Connecticut Health Center $25,505
  • Ecir Miami Holdings Llc $24,150
  • Advanced Research Center $23,754
  • Research in Miami, Inc $21,595
  • Five Towns Neurology, PC $20,586
  • Arrow Clinical Trials $19,681
  • Envision Trials, Llc $19,120
  • Interspond, Llc $18,075
  • Triad Clinical Trials $18,042
  • Quantum Laboratories, Inc $17,501
  • $17,139
  • Pacific Neuropsychiatric Specialists $16,947
  • Aqualane Clinical Research $16,200
  • Instituto De Neurologia Dra. Ivonne Fraga $15,862
  • Serenity Research Center $13,959
  • Panax Clinical Research $13,547
  • Advanced Memory Research Institute of New Jersey $13,250
  • West Clinical Research $12,348
  • Orange County Neuropsychiatric Research Center , Llc $12,022
  • Vanderbilt University Medical Center, TN $8,265
  • Scb Research Center $7,293
  • Stein Gerontological Institute $4,937
  • Prospective Research Innovations $3,144
  • New Life Medical Research Center $749
  • Premiere Research Institute at Palm Beach Neurology $685
  • Nexus Clinical Research Center- Nrc $637
  • Floridian Research Institute, Llc $605
  • Icon Salt Lake City $588
  • Jy Research Institute $587
  • Advanced Neurology Center $582
  • Dade Research Center - Miami Fl - 7600 Southwest 87th Avenue $582
  • Angels Clinical Research Institute - Miami Lakes - PAlm Springs - Ppds $579
  • Pra Health Sciences- Lenexa $575
  • A and D Doctor Center, Llc $566
  • Combined Research Orlando $552
  • Sc3 Research Group, Inc $540
  • Banner Alzheimer's Institute $525
  • Nrc Research Institute $506
  • Long Beach Research Institute $506
  • Imic Llc- 9380 Southwest 150th Str $505
  • Chandler Clinical Trials $499
  • Mclean Hospital Corporation, MA $416
  • Interventional Psychiatry of Tampa Bay $385
  • Barbara Diaz Hernandez, MD Research, Inc $362
  • Miami Jewish Home & Hospital $328
  • Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital $301
  • Ohio State University $294
  • Santa Cruz Behavioral $283
  • Sensible Healthcare $246
  • Gilbert Neurology PArtners PLLC $201
  • Inland Psychiatric Medical Group, Inc $198
  • Insight Clinical Trials, Llc $158
  • Nova Psychiatry, Inc $31

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.