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A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)

Active, not recruiting · Phase 3 · NCT06653153

Conditions: Alzheimer's Disease

At a glance

Research payments reported, 2025
$55.8M
U.S. investigators named
123
Sites paid
135
Planned or actual enrollment
1,400

About the trial

Sponsor
Eli Lilly and Company
Tested
Remternetug (drug), Placebo (drug)
Dates
Started 2024-10-24; completion 2030-10
Results posted
Not yet

The purpose of this study is to measure the difference in time to developing or worsening memory, thinking, or functional problems due to Alzheimer's disease occurring in participants receiving study drug compared to placebo. Participation could last up to 255 weeks including screening, a double-blind treatment period, and a double-blind observation period. In addition, eligible participants who receive placebo during the double-blind treatment period may choose to extend their study participation to receive open-label remternetug in an extension period.

From ClinicalTrials.gov, last updated 2026-10-07. Full record, eligibility and contacts (opens in a new tab)

Industry funding

Eli Lilly and Company reported $55.8M in research payments for this study in 2025 (280 payments).

Products named: Amyvid

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • K2 Medical Research LLC $4.4M
  • Charter Research LLC $4.1M
  • Indago Research & Health Center Inc $3.5M
  • Adams Clinical Inc $3.2M
  • Care Access Research LLC $3.1M
  • Las Vegas Medical Research LLC $2.8M
  • Northwest Clinical Research Center $1.9M
  • Revival Research Institute LLC $1.8M
  • Progressive Medical Concepts LLC $1.5M
  • Adult Medicine of Lake County $1.4M
  • Tandem Intermediate LLC $1.3M
  • Irvine Center for Clinical Research Inc $1.2M
  • Conquest Research LLC $1.1M
  • New Age Medical Research Corp $1.0M
  • Monroe Biomedical Research $999,422
  • Re Cognition Health Corporation $905,542
  • Ima Evaluations LLC DBA Ima Clinical Research $887,783
  • Clinical Research Professionals LLC $823,850
  • Adventhealth Orlando, FL $806,320
  • Gadolin Research LLC $783,632
  • Jem Headlands LLC $777,503
  • Center for Advanced Research & Education LLC $742,341
  • Bradenton Research Center Inc $610,289
  • Premier Research Institute $551,386
  • Artemis Headlands LLC $541,685
  • Medvadis Research Corp LLC $539,856
  • North Georgia Clinical Research $533,920
  • Cedar Valley Medical Specialists $465,864
  • Alpine Clinical Research Center Inc $449,853
  • Northwest Clinical Trials Inc $420,599
  • Medication Management LLC $418,912
  • Clinical Research Philadelphia LLC $418,300
  • 121 Domenech Ave $417,462
  • Axiom Brain Health LLC $413,696
  • Nluc PLLC $407,424
  • Banner Alzheimers Institute $398,273
  • Erg Holding Co LLC DBA St Louis Clinical Trials LLC $395,295
  • $393,640
  • Scb Research Center Corp $345,857
  • Aqualane Clinical Research LLC $344,543
  • Mdfirst Research Chandler LLC $329,536
  • Tribe Clinical Research LLC $327,818
  • Rainier Clinical Research Center $289,353
  • Kerwin Memory Center LLC $269,636
  • North Star Medical Research LLC $265,880
  • Keystone Clin Studies $255,983
  • Great Lakes Clinical Trials $243,767
  • Quest Research Institute LLC $239,664
  • Old Dominion University $233,946
  • University of Texas Health $232,708
  • El Faro Health and Therapeutics PLLC $230,158
  • Neuro PAin Medical Center Inc $228,159
  • St Jude Heritage Healthcare $225,222
  • Neurology Clinic PC $216,781
  • Invicro $215,536
  • James G Sullivan DBA PArkway Medical Ctr $204,696
  • Citizens Memorial Hospital District $194,672
  • Sharp Mesa Vista Hospital $192,389
  • Advanced Memory Research Institute of Nj PC $189,344
  • Clinical Trials Research Inc $189,026
  • Raa Apex Acquisition LLC $180,877
  • Elizabeth Peckham Do Central Texas Neurology Consultants $173,728
  • Cenexel Rocky Mountain Researc $173,161
  • Renstar Inc $167,030
  • Cotton Oneil Msd of Stormont Vail Healthcare $165,569
  • Center for Biomedical Research $151,735
  • Ki Health PArtners LLC $143,596
  • Consano Clinical Research LLC $141,536
  • Tectum Medical Research LLC $138,500
  • Suncoast Clinical Research $137,594
  • Thomas M Shiovitz MD Inc $137,365
  • Alexian Brothers Health System $135,858
  • Josephson Wallack Munshower Neurology $132,750
  • Flourish Research Acquisition LLC $124,600
  • Cognitive and Research Center of New Jersery LLC $117,280
  • California PAcific Medical Ctr-Davies Campus Hosp, CA $112,860
  • Rhode Island Mood and Memory Research $109,166
  • Emerald Coast Neurology $108,960
  • Inspira Mental Health Management Inc $106,153
  • Boston Clinical Trials LLC $99,340
  • Healthpartners Institute for Education $96,649
  • Instituto De Neurologia Dra Ivonne Frag Psc $90,100
  • Stedman Clinical Trials $87,760
  • Palmetto Clinical Research Low Country $85,631
  • Unehealth $82,738
  • The Neuron Clin - Escondido $65,530
  • Cenexel Iresearch LLC $47,181
  • Hattiesburg Clinic PA $42,995
  • Visionary Investigators Network $40,989
  • Butler Hospital, RI $38,898
  • Adams Clinical LLC $33,966
  • Medex Healthcare Research Inc $32,054
  • Compass Research East LLC $30,953
  • Senior Adult Specialty Research $23,887
  • Lightship Inc $21,350
  • Collaborative Neuroscience Research LLC $21,158
  • Northern Light Eastern Maine Medical Center, ME $19,787
  • Alison B Allen MD $19,663
  • Jem Research LLC $18,095
  • Alicia Cabrera $17,169

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.