A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
Active, not recruiting · Phase 3 · NCT06662383
Conditions: Obesity
At a glance
- Research payments reported, 2025
- $17.9M
- U.S. investigators named
- 42
- Sites paid
- 51
- Planned or actual enrollment
- 800
About the trial
- Sponsor
- Eli Lilly and Company
- Tested
- Retatrutide (drug), Tirzepatide (drug)
- Dates
- Started 2024-11-01; completion 2026-12
- Results posted
- Not yet
The main purpose of this study is to evaluate the efficacy and safety of retatrutide compared to tirzepatide in adults who have obesity. The study will last about 89 weeks.
From ClinicalTrials.gov, last updated 2026-07-20. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Eli Lilly and Company reported $17.9M in research payments for this study in 2025 (102 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Jeffrey R. Hoodin, M.D. Internal Medicine · Tempe, AZ
- David T. Ahn, MD Endocrinology & Diabetes · Newport Beach, CA
- Hanid Audish, DO Family Medicine · Spring Valley, CA
- Stacey L. Layle, MD Family Medicine · San Diego, CA
- Helen L. Stacey, MD Internal Medicine · Walnut Creek, CA
- Timothy D. Colander, MD Family Medicine · Aurora, CO
- Ania M. Jastreboff, M.D., PH.D. Endocrinology & Diabetes · New Haven, CT
- Charles Landau, MD Cardiology · Trumbull, CT
- Stuart W. Zarich, M.D. Cardiology · Bridgeport, CT
- Mark E. Kutner, MD Internal Medicine · Miami, FL
- Jose E. Negrin, MD Hospitalist · Homestead, FL
- Rodolfo A. Perez, M.D. Specialist · Hialeah, FL
- Jeffrey Schneider, M.D. Gastroenterology · Coral Springs, FL
- Liubou Uslar, M.D. Internal Medicine · Hallandale Beach, FL
- Charles H. Nash III, MD Medical Oncology · Gainesville, GA
- Anthony A. Olofintuyi, M.D. Internal Medicine · Columbus, GA
- Rabahuddin Syed, M.D. Internal Medicine · Alpharetta, GA
- Cindy H. Pau, MD Endocrinology & Diabetes · Honolulu, HI
- James A. Coggi, M.D. Pediatrics · West Des Moines, IA
- Thomas J. Schnitzer, MD, PHD Sports Medicine · Chicago, IL
- Jeffrey A. Potts, MD Internal Medicine · Bay City, MI
- Derrick Williamson, DO Family Medicine · Southfield, MI
- Timothy R. Smith, M.D. Internal Medicine · Saint Peters, MO
- Awawu E. Igbinadolor, M.D. Adolescent Medicine · Monroe, NC
- Alexander V. Murray, M.D. Family Medicine · Greensboro, NC
- John C. Parker, M.D. Endocrinology & Diabetes · Wilmington, NC
- Michael J. Lillestol, M.D. Internal Medicine · Fargo, ND
- Quang T. Nguyen, DO Endocrinology & Diabetes · Henderson, NV
- Robert S. Busch, M.D. Endocrinology & Diabetes · Albany, NY
- Michael Goldberg, M.D. Endocrinology & Diabetes · Valhalla, NY
- Steven B. Heymsfield, MD Internal Medicine · New York, NY
- Jennifer Leong Hepatology · New York, NY
- William J. Randall, MD Family Medicine · Kettering, OH
- Elizabeth A. Barranco, MD Internal Medicine · Ponce, PR
- Ronald K. Mayfield, M.D. Endocrinology & Diabetes · Spartanburg, SC
- Obadias Marquez, MD Internal Medicine · Ooltewah, TN
- Wilner E. Jeudy, MD Family Medicine · Sugar Land, TX
- Mazen Noureddin, M.D. Gastroenterology · Houston, TX
- Christopher Romero, MD Internal Medicine · Houston, TX
- Michelle D. Welch, MD Endocrinology & Diabetes · Shavano Park, TX
- Joseph H. Woolley, M.D. Internal Medicine · Saint George, UT
- James R. Clark, MD Internal Medicine · Charlottesville, VA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Northwestern University $854,476
- Primed Clinical Research LLC $822,086
- Encore Medical Research, LLC $815,886
- Flourish Research Acquisition LLC $780,756
- Precision Clinical Research LLC $748,875
- Great Lakes Research Group Inc $739,895
- Consano Clinical Research LLC $725,075
- Onhealth Research Center LLC $673,111
- Encompass Clinical Research $622,042
- Sociedad Espanola De Medicina De La Adolescencia $615,614
- Chrysalis Clinical Research LLC $579,047
- Piedmont Medical Research Associates Inc $564,545
- Artemis Headlands LLC $531,079
- Innovative Clinical Research DBA Pivotal Research Solutions $527,640
- Monroe Biomedical Research $512,682
- Nluc PLLC $503,055
- Bridgeport Hospital, CT $453,811
- Tribe Clinical Research LLC $448,364
- Lillestol Research LLC $440,629
- Medical Advancement Centers of Arizona LLC $416,782
- David Fitzpatrick MD DBA E West Med Rsrch $400,601
- Ponce School of Medicine $396,170
- Great Lakes Research Institute LLC $392,059
- Pharmquest Life Sciences LLC $391,632
- Houston Research Institute LLC $361,547
- Studymetrix Research LLC $336,381
- Einstein Clinical Research Inc $330,609
- Las Vegas Endocrinology $327,779
- Headlands Horizons LLC $304,551
- Clincept Clinical Research Mh Columbus $287,148
- Yale University $272,074
- Hoag Memorial Hospital Presbyterian $256,756
- New York Medical College $254,370
- Integrated Clinical Trial Services Inc $233,392
- New York Gastroenterology Associates $230,397
- Wr Clinsearch LLC $216,209
- Albany Medical College $137,816
- Clark Medical Research LLC $109,364
- Northeast Georgia Medical Center, Inc, GA $67,782
- Eximia Research Acquisition Ho $54,671
- Lynn Health Science Institute $46,267
- $34,063
- Board of Supervisors of La State $24,518
- Suncoast Research $9,263
- Mountain View Clinical Research Inc $6,823
- Capital Clinical Research Center PLLC $6,640
- Next Level Urgent Care LLC $6,198
- Pharmquest LLC $5,236
- Rheumatology Center of Houston $5,161
- Cahaba Research $4,974
- Driscoll Childrens Hospital, TX $2,705
- Seattle Institute for Biomed and Clinical Rsrch $1,259
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.