Skip to main content

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

Recruiting · Phase 3 · NCT06822738

Conditions: Primary Open Angle Glaucoma

At a glance

Research payments reported, 2025
$653,687
U.S. investigators named
18
Sites paid
18
Planned or actual enrollment
130

About the trial

Sponsor
AbbVie
Tested
XEN63 Glaucoma Treatment System (device)
Dates
Started 2025-02-11; completion 2028-11
Results posted
Not yet

Glaucoma is the second most common cause of blindness in the world, second only to cataracts. This study will assess how safe and effective a glaucoma gel stent is when implanted using the ab interno (inside the eye) and ab externo (outside the eye) approach. Adverse events and intraocular pressure will be assessed. XEN63 is an investigational device for the treatment of intraocular pressure (IOP) in patients with glaucoma when both medical and conventional surgical treatments have failed (for US approval) and when medical treatments have failed (for outside US \[OUS\] approval). Participants will be placed in one of two groups called study arms. One group will receive the XEN63 gel stent…

From ClinicalTrials.gov, last updated 2026-10-09. Full record, eligibility and contacts (opens in a new tab)

Industry funding

AbbVie Inc. reported $653,687 in research payments for this study in 2025 (80 payments).

Products named: Xen Glaucoma Treatment System

Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.

U.S. investigators named on this study

Clinicians the company named as principal investigators in its Open Payments reports.

Sites paid to run it

  • El PAso Eye Surgeons PA $151,073
  • Coastal Research Associates LLC $91,149
  • New Vision Eye Center LLC $53,573
  • The University of Texas $50,980
  • Glaucoma Associates of Texas PA $49,412
  • Minnesota Eye Consultants PA $39,180
  • Arizona Advanced Eye Research $38,584
  • Vance Thompson Vision Clinic $35,725
  • Migs Consulting LLC $26,765
  • Wills Eye Hospital $20,938
  • Los Angeles Vision Center Inc $18,000
  • Regents of University of Colorado $16,640
  • Ophthalmic PArtners PC $10,562
  • North Bay Eye Associates Inc $10,315
  • Eye Center of Racine & Kenosha LTD $10,093
  • Vistar Eye Center Inc $10,093
  • Wyman-Sicher Eye Associates $10,093
  • Stiles Eyecare Excellence And $10,093
  • $420

Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.