A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)
Completed · Phase 1 · NCT06834789
Conditions: Glabellar Lines
At a glance
- Research payments reported, 2025
- $3.4M
- U.S. investigators named
- 8
- Sites paid
- 10
- Planned or actual enrollment
- 132
About the trial
- Sponsor
- AbbVie
- Tested
- AGN-151586 (drug), OnabotulinumtoxinA (drug), Placebo (drug)
- Dates
- Started 2025-02-18; completion 2025-11-03
- Results posted
- Not yet
The objective of this Phase 1 study is to assess the safety and efficacy of single treatment of AGN-151586 and of OnabotulinumtoxinA in the glabellar complex of participants with moderate to severe glabellar lines (GL).
From ClinicalTrials.gov, last updated 2025-11-17. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $3.4M in research payments for this study in 2025 (66 payments).
Products named: Botox
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Brenda M. Latowsky, MD Dermatology · Scottsdale, AZ
- David L. Wirta, MD Ophthalmology · Newport Beach, CA
- Terrence C. Keaney, M.D Dermatology · Washington, DC
- Joely Kaufman-janette, MD Dermatology · Coral Gables, FL
- Jeffrey S. Dover, MD Dermatology · Chestnut Hill, MA
- Keith Marcus, MD Internal Medicine · Ludington, MI
- Rosalyn George, M.D. Dermatology · Wilmington, NC
- Edward L. Lain, M.D. Dermatology · Austin, TX
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Eye Research Foundation Inc $613,462
- Wdc Cosmetic and Research PLLC $543,527
- Pflugerville Dermatology Clinical $479,941
- Keith A Marcus MD Inc $464,893
- Investigate MD LLC $379,919
- Skincare Physicians Inc $339,675
- Skin Research Institute LLC $328,515
- Skin Dc PLLC $205,901
- Skincare Physicians $2,178
- Marcus Facial Plastic Surgery $2,178
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.