Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder
Recruiting · Phase 2 · NCT06846320
Conditions: Generalized Anxiety Disorder (GAD)
At a glance
- Research payments reported, 2025
- $2.0M
- U.S. investigators named
- 53
- Sites paid
- 74
- Planned or actual enrollment
- 315
About the trial
- Sponsor
- AbbVie
- Tested
- ABBV-932 (drug), Placebo for ABBV-932 (drug), Antidepressant Therapy (ADT) (drug)
- Dates
- Started 2025-04-29; completion 2026-11
- Results posted
- Not yet
Generalized anxiety disorder (GAD) is usually treated with antidepressant therapy (ADT); however, sometimes ADTs alone are not enough to adequately treat GAD. The purpose of this study is to assess how safe and effective ABBV-932 is when added to the antidepressant therapies in adult participants with GAD who have had an inadequate response ADTs. ABBV-932 is an investigational drug being developed for the adjunctive treatment of GAD. Participants will be randomly assigned to receive ABBV-932 or Placebo in addition to their currently prescribed ADTs. There is 1 in 3 chance of participants assigned to Placebo. Approximately 315 adult participants with GAD and inadequate response to ADTs wil…
From ClinicalTrials.gov, last updated 2026-06-17. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $2.0M in research payments for this study in 2025 (388 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Richard Shelton Psychiatry · Birmingham, AL
- Payam M. Sadr, MD Psychiatry · Mesa, AZ
- Brandon Yates, MD Psychiatry · Tucson, AZ
- Pamela L. Alvarez, M.D. Neurology · Murrieta, CA
- Ira Glick Psychiatry · Stanford, CA
- Neeraj Gupta, MD Orthopedic Surgery · Pomona, CA
- Bernardo Ng, M.D Psychiatry · Imperial, CA
- Charmaine I. Semeniuk, M.D. Psychiatry · San Diego, CA
- Susan M. Smiga, M.D. Psychiatry · Sacramento, CA
- Sherry Soefje, M.D. Psychiatry · Oceanside, CA
- Kevin Stephanoff, MD Psychiatry · Torrance, CA
- Ronald L. Warnell, M.D. Psychiatry · Redlands, CA
- Charles B. Montano, MD Internal Medicine · Cromwell, CT
- Leonardo Alonso, M.D. Psychiatry · Miami, FL
- Rosario B. Hidalgo, MD Psychiatry · Tampa, FL
- Nandita J. Jones, MD Psychiatry · Jacksonville, FL
- Morteza Nadjafi, M.D. Psychiatry · Orlando, FL
- Michael M. Pfeffer, MD Neurology · Miami, FL
- Michael D. Banov, MD Psychiatry · Marietta, GA
- Michael C. Mobley, M.D. Psychiatry · Savannah, GA
- Jon Grant Psychiatry · Chicago, IL
- Haydn M. Thomas, M.D. Psychiatry · Prairie Village, KS
- Elia E. Acevedo Diaz, M.D Psychiatry · Gaithersburg, MD
- John P. Canale, M.D. Psychiatry · O Fallon, MO
- Gregory W. Mattingly, M.D. Psychiatry · Saint Charles, MO
- Junaid M. Syed, M.D. Psychiatry · Saint Louis, MO
- Kurian C. Abraham, MD Psychiatry · Charlotte, NC
- Ashok K. Patel, M.D. Specialist · Toms River, NJ
- Mustafa M. Rawaf, DO Psychiatry · Las Vegas, NV
- Zinoviy Benzar, M.D. Psychiatry · Brooklyn, NY
- James P. Wolberg, MD Addiction Medicine · New York, NY
- Inna N. Yuryev-golger, MD Psychiatry · Brooklyn, NY
- Diab Almhana, MD Psychiatry · Avon Lake, OH
- Jeffrey R. Strawn, MD Psychiatry · Cincinnati, OH
- Subhdeep Virk, MD Psychiatry · Columbus, OH
- Veronique Sebastian, MD Psychiatry · Oklahoma City, OK
- Paul K. Gross, M.D. Psychiatry · Allentown, PA
- Shivkumar S. Hatti, MD., MBA Psychiatry · Media, PA
- Yvette M. Cruz, M.D. Psychiatry · San Juan, PR
- Ivonne De L Fraga Berrios, MD Neurology · San Juan, PR
- Ileana M. Fumero, M.D. Psychiatry · San Juan, PR
- Sejal Patel, M.D. Military Health Care Provider · Columbia, SC
- Paul I. Robbins, MD Psychiatry · Summerville, SC
- James R. Hart, M.D. Psychiatry · Franklin, TN
- Mohammad Ashfaque, MD Psychiatry · Richmond, TX
- Benny Barnhart, M.D. Psychiatry · Wichita Falls, TX
- Michael J. Downing, MD Psychiatry · Dallas, TX
- Seema A. Gupta, M.D. Psychiatry · Dallas, TX
- Aqeel Hashmi, M.D. Psychiatry · Richmond, TX
- Marshall B. Lucas, MD Psychiatry · The Woodlands, TX
- Omer Abdullah, MD Internal Medicine · Burke, VA
- Arun Arora, M.D. Psychiatry · Bellevue, WA
- James A. Knutson, M.D. Prescribing Psychologist · Kirkland, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Allied Biomedical Research $193,606
- Viking Pharmaceutical Trials Inc $141,732
- Northwest Clinical Research Ctr $119,395
- New Hope Clinical Research Inc $119,300
- University of Cincinnati $110,716
- Lehigh Center for Clinical Research $105,550
- Bio Behavioral Health $93,605
- Atlas Intermediate LLC $58,216
- Sooner Clinical Research Inc $53,897
- Im Super Holdings LLC $49,325
- Oasis Clinical Research LLC $47,577
- Sunwise Clinical Research LLC $41,686
- Psychiatric Care and Research $41,476
- Clinical Neuroscience Solutions in $41,430
- Sun Valley Research Center Inc $40,622
- University of Alabama Hospital, AL $36,902
- Global Medical Institutes $35,778
- Coastal Carolina Research Cntr LLC $35,153
- St Charles Psychiatric Associates $32,776
- The Ohio State University $31,379
- Apg Research LLC $29,288
- Cbh Health LLC $28,164
- Axiom Research LLC $25,495
- The University of Chicago $25,042
- Excell Research Inc $24,717
- Sandhill Research LLC $24,018
- K2 Medical Research Maitland LLC $23,816
- Cenexel Iresearch LLC $23,062
- Arch Clinical Trials LLC $22,978
- Eastside Therapeutic Resource Inc $22,525
- Global Medical Institutes LLC $21,767
- $21,516
- Barbara Diaz Hernandez $19,617
- Haidar Almhana Nieding LLC $19,462
- Collective Medical Research LLC $19,400
- Relaro Medical Trials LLC $19,023
- Erg Clinical Research California PC $18,668
- Perceptive Pharma Research LLC $17,791
- Noble Clinical Research LLC $16,292
- Elixia Ma LLC $16,268
- Mrc Geriatric Services Inc $14,887
- Instituto De Neurologia $14,500
- Psychiatric Consultants PC $13,846
- Inspira Mental Health Management $12,500
- Psych Atlanta PC $11,027
- Accellacare US Inc $11,027
- Ima Evaluations LLC $4,384
- Viking Clinical Research $3,759
- Montano Wellness LLC $3,713
- Elligo Health Research Inc $3,446
- Grayline Research Center $3,446
- Coastal Carolina Research Center $3,446
- Atlas Intermediate $3,446
- Saint Charles Psychiatric Associates and Midwest Research Group $3,446
- Northwest Clinical Research Center $3,446
- Psychiatric Care and Research Center $3,446
- Inspira Caguas $3,446
- Sunwise Clinical Research $3,446
- Clinical Neuroscience Solutions Inc $3,446
- Cenexel Iresearch Atlanta $3,132
- Collective Medical Research $3,132
- Elixia $3,132
- Allied Biomedical Research Institute $3,132
- Haidar Almhana and Nieding LLC $3,132
- Northwest Behavioral Research Center $3,132
- Eastside Therapeutic Resources $2,819
- Ohio State University $2,819
- Asclepes Research Centers $2,819
- Oasis Clinical Research $2,506
- Fraga Berrios Ivone Office $2,192
- Relaro Medical Trials $1,565
- Family Psychiatry of the Woodlands $1,252
- Futuresearch Trials $939
- Ucm Emergency Department Outpatient Pharmacy $939
- Integrative Clinical Trials $625
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.