ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Recruiting · Phase 2 · NCT06902558
Conditions: Autosomal Dominant Polycystic Kidney Disease
At a glance
- Research payments reported, 2025
- $658,703
- U.S. investigators named
- 28
- Sites paid
- 28
- Planned or actual enrollment
- 240
About the trial
- Sponsor
- Calico Life Sciences LLC
- Tested
- ABBV-CLS-628 (drug), Placebo (drug)
- Dates
- Started 2025-06-09; completion 2029-08
- Results posted
- Not yet
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of ADPKD in adult participants. ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD. Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to placebo. Around 240 adult participants with ADPKD will be enrolled at approximately 100 sites worldwide. Participants will receive IntraVenous ABBV-CLS…
From ClinicalTrials.gov, last updated 2026-10-06. Full record, eligibility and contacts (opens in a new tab)
Industry funding
AbbVie Inc. reported $658,703 in research payments for this study in 2025 (141 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Rebecca Ahdoot, M.D. Nephrology (Kidney) · Orange, CA
- Mohamed A. El-shahawy, M.D. Nephrology (Kidney) · Los Angeles, CA
- Kaushik Ivaturi Internal Medicine · Sacramento, CA
- Meyeon Park, MD Nephrology (Kidney) · San Francisco, CA
- Tariq Shah, M.D. Nephrology (Kidney) · Los Angeles, CA
- Fouad Chebib, M.D Nephrology (Kidney) · Jacksonville, FL
- Herminio Garcia-estrada, MD Nephrology (Kidney) · Miami, FL
- Edouard R. Martin, M.D. Nephrology (Kidney) · Lauderdale Lakes, FL
- Smita Padala, M.D. Internal Medicine · Lecanto, FL
- Frederic F. Rahbari Oskoui, MD Nephrology (Kidney) · Atlanta, GA
- Raquel O. Alencar, M.D., PH.D. Radiology · Boston, MA
- Craig E. Gordon, MD Nephrology (Kidney) · Boston, MA
- Vikram A. Sahni, M.D. Radiology · Wellesley, MA
- Nisha I. Sainani, M.D. Radiology · Boston, MA
- Keith Bellovich, DO Nephrology (Kidney) · Roseville, MI
- Michael Heung, MD Nephrology (Kidney) · Ann Arbor, MI
- Neera K. Dahl, MD Nephrology (Kidney) · Rochester, MN
- Emily H. Chang, MD Nephrology (Kidney) · Sanford, NC
- Gregory T. Greenwood, M.D. Nephrology (Kidney) · Winston-salem, NC
- Priya P. Deshpande, M.D. Nephrology (Kidney) · New York, NY
- Mark Anderson, M.D. Cardiology · Oklahoma City, OK
- Nelson P. Kopyt, DO Nephrology (Kidney) · Allentown, PA
- Claude M. Galphin, MD Nephrology (Kidney) · Chattanooga, TN
- Kendra S. Hendon, M.D. Nephrology (Kidney) · Knoxville, TN
- Bhasker R. Mehta, MD Nephrology (Kidney) · Arlington, TX
- Pablo E. Pergola, MD Nephrology (Kidney) · San Antonio, TX
- Michael Wiederkehr, M.D. Nephrology (Kidney) · Dallas, TX
- Osama Amro, MD., MS Nephrology (Kidney) · Seattle, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Uci Health-Orange, CA $57,881
- UCSF Langley Porter Psychiatric Hospital and Clinics, CA $47,036
- Icahn School of Med at Mt Sinai $45,703
- University of Michigan Health System, MI $45,259
- University of North Carolina at Chapel Hill $38,520
- $35,139
- Tufts Medical Center, MA $34,660
- Nature Coast Clinical Research $32,194
- Swedish Medical Center, WA $30,500
- Mayo Clinic $25,560
- Academic Medical Research Institute $23,930
- South Florida Research Institute $21,531
- Emory University Hospital, GA $21,463
- Valiance Clinical Research - Huntington PArk $21,000
- Northeast Clinical Research Center $20,178
- Knoxville Kidney Center PLLC $19,708
- St Clair Nephrology Research LLC $18,533
- Yium Shenouda & Miller PArtnership $17,627
- National Institute of Clinical $17,431
- Mayo Clinic Jacksonville $15,060
- Brookview Hills Research Associates $14,964
- Renal Disease Research Institute $14,900
- Arlington Nephrology PLLC $14,800
- Clinical Advancement Center PLLC $13,476
- Vx3 Imaging PC $3,140
- Ns Imaging Related Services Inc $2,920
- Scientia Imaging LLC $2,880
- Mgpo Radiology Associates $2,260
- Horizon Research Group $450
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.