A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
Recruiting · Phase 3 · NCT06976203
Conditions: Alzheimer's Disease
At a glance
- Research payments reported, 2025
- $29,116
- U.S. investigators named
- 19
- Sites paid
- 19
- Planned or actual enrollment
- 586
About the trial
- Sponsor
- Bristol-Myers Squibb
- Tested
- KarXT (drug), KarX-EC (drug), Placebo (other)
- Dates
- Started 2025-07-21; completion 2029-02-23
- Results posted
- Not yet
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease
From ClinicalTrials.gov, last updated 2026-10-08. Full record, eligibility and contacts (opens in a new tab)
Industry funding
E.r. Squibb & Sons, L.l.c. reported $29,116 in research payments for this study in 2025 (20 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Jack H. Florin, MD Neurology · Fullerton, CA
- Elly R. Lee, MD Psychiatry · Irvine, CA
- Craig T. Curtis, MD Family Medicine · Kissimmee, FL
- Amanda G. Smith, MD Psychiatry · Tampa, FL
- Jennifer Springer, MD Emergency Medicine · Fort Myers, FL
- Steven A. Toenjes, MD Neurology · Jacksonville, FL
- Jennifer M. Arnold, MD Neurology · Springfield, IL
- Jeffrey S. Ross, M.D. Psychiatry · Northbrook, IL
- Kristi K. George, MD Neurology · Indianapolis, IN
- Stephanie B. Rutrick, MD Neurology · Boston, MA
- Aaron L. Ellenbogen, D.O. Neurology · Farmington Hills, MI
- Ronald L. Schwartz, MD Neurology · Hattiesburg, MS
- Mark W. Ornstein, M.D. Internal Medicine · Farmingdale, NJ
- Richard F. Holub, MD Neurology · Albany, NY
- Kinga Szigeti, M.D. Neurology · Buffalo, NY
- Cameron S. Olezene, MD Physical Medicine & Rehabilitation (PM&R) · Philadelphia, PA
- William Julio De Jesus, MD Psychiatry · Bayamon, PR
- Edward Y. Zamrini, MD Neurology · Salt Lake City, UT
- Sheryl M. Marks, MD Anesthesiology · Renton, WA
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Keystone Clinical Studies $2,893
- Inglewood Clinical $2,537
- Neurological Associates of Albany, PC $1,893
- Jacksonville Center for Clinical Research $1,623
- Quest Research Institute $1,519
- Fullerton Neurology and Headache Center $1,493
- Great Lakes Clinical Trials $1,488
- K2 Medical Research the Villages $1,413
- Hattiesburg Clinic Neurology $1,370
- Santa Cruz Behavioral $1,354
- Neuropsychiatric Research Center of Southwest Florida $1,351
- Irvine Center for Clinical Research, Incorporated $1,338
- The Ubmd Physicians Group Neurology $1,333
- Rainier Clinical Research Center $1,320
- Usf Health Byrd Alzheimers Institute $1,245
- Adams Clinical Trials Llc $1,242
- Southern Illinois University School of Medicine $1,179
- Advanced Clinical Institute, Inc $1,175
- Josephson Wallack Munshower Neurology, PC $1,150
- $200
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.