A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease
Recruiting · Phase 3 · NCT07011745
Conditions: Alzheimer's Disease
At a glance
- Research payments reported, 2025
- $42,609
- U.S. investigators named
- 11
- Sites paid
- 9
- Planned or actual enrollment
- 426
About the trial
- Sponsor
- Bristol-Myers Squibb
- Tested
- Xanomeline/Trospium Chloride Capsule (drug), Xanomeline Enteric Capsule (drug), Placebo (drug)
- Dates
- Started 2025-07-16; completion 2028-11-13
- Results posted
- Not yet
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC in adult participants with agitation related to Alzheimer's Disease.
From ClinicalTrials.gov, last updated 2026-11-03. Full record, eligibility and contacts (opens in a new tab)
Industry funding
E.r. Squibb & Sons, L.l.c. reported $42,609 in research payments for this study in 2025 (9 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
- Muhammad O. Salim Khan Sports Medicine · Gilbert, AZ
- Deborah L. Steinberg, M.D. Psychiatry · Fresno, CA
- Alison B. Allen, MD Neurology · Basalt, CO
- Ari Magill, MD Neurology · Aurora, CO
- Daniel F. Mandri, MD Psychiatry · Miami, FL
- Nicholas J. Weber, D.O. Student in an Organized Health Care Education/Training Program · Olympia Fields, IL
- David W. Brown, M.D. Psychiatry · Austin, TX
- Andrea V. Brown, M.D. Family Medicine · Desoto, TX
- Laquita A. Shepherd, MD Family Medicine · Mesquite, TX
- Jackson M. Rhudy, MD Emergency Medicine · Salt Lake City, UT
- Malgorzata Franczak, MD Neurology · Milwaukee, WI
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Envision Trials, Llc $23,311
- Mountain Neurological Research Center $6,573
- Epic Medical Research, Llc - Carrolton $4,075
- Epic Medical Research $3,562
- Key Clinical Research $1,161
- Medical College of Wisconsin $1,120
- Chandler Clinical Trials $1,041
- Infinity Clinical Trials $1,040
- Pantheon Clinical Research $726
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.