IRONICA: IRON Repletion In Heart Failure - A Comparison of Oral and IV Approaches
Terminated · Phase 4 · NCT07053475
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Heart Failure With Preserved Ejection Fraction (HFPEF), Iron Deficiency, Iron-deficiency Anemia (IDA)
At a glance
- Research payments reported, 2025
- $3,000
- U.S. investigators named
- 1
- Sites paid
- 1
- Planned or actual enrollment
- 42
About the trial
- Sponsor
- Syed Hamza Mufarrih (with American Regent, Inc.)
- Tested
- Ferric Carboxymaltose (drug), Ferrous Sulfate (drug)
- Dates
- Started 2025-04-02; completion 2026-03-31
- Results posted
- Not yet
The goal of this clinical trial is to learn which iron treatment works better for adults with congestive heart failure and low iron levels: intravenous (IV) iron given through a vein or oral (PO) iron taken by mouth. Participants must have heart failure with reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF) and a transferrin-saturation (TSAT) level below 20 percent. The main questions the study will answer are: 1. Does IV iron raise walking distance on a 6-minute walk test more than oral iron after 24 weeks? 2. Does IV iron improve symptoms and quality of life more than oral iron? 3. How do the two treatments compare for safety, side effects, and hospital readmissio…
From ClinicalTrials.gov, last updated 2026-07-20. Full record, eligibility and contacts (opens in a new tab)
Industry funding
American Regent reported $3,000 in research payments for this study in 2025 (1 payments).
Products named: Injectafer
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
- Western Kentucky Heart and Lung Research Foundation and Educational Trust $3,000
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.