A Comparison of Cyclic Manual Direct Aspiration Thrombectomy (Plunger Technique) vs. Static Manual Direct Aspiration Thrombectomy for Treatment of Acute Large Vessel Occlusion Stroke
Recruiting · Not applicable · NCT07231380
Conditions: Acute Ischemic Stroke Patients, Large Vessel Occlusion
At a glance
- Research payments reported, 2025
- $400,000
- U.S. investigators named
- 1
- Sites paid
- 1
- Planned or actual enrollment
- 500
About the trial
- Sponsor
- Vanderbilt University Medical Center (with Balt USA)
- Tested
- Plunger Technique (procedure), Static Manual Aspiration Thrombectomy (procedure)
- Dates
- Started 2026-08-04; completion 2027-06-01
- Results posted
- Not yet
This prospective, randomized controlled trial will compare two manual aspiration techniques for treating acute ischemic stroke due to large vessel occlusion: cyclic aspiration (Plunger technique) and static aspiration. Both techniques use FDA-approved devices (Raptor Aspiration Catheters and VacLok syringes) and are standard of care. Approximately 500 participants across 20 sites will be randomized to one of the two techniques. The primary endpoint is First Pass Effect (TICI 2c/3 after first attempt), with secondary endpoints including overall recanalization and 90-day functional outcomes. Results will address a critical gap in optimizing aspiration thrombectomy techniques.
From ClinicalTrials.gov, last updated 2026-10-06. Full record, eligibility and contacts (opens in a new tab)
Industry funding
Balt USA, LLC reported $400,000 in research payments for this study in 2025 (2 payments).
Research payments usually go to hospitals, universities and research sites to run a study, not to the investigators personally. A payment is not evidence of wrongdoing.
U.S. investigators named on this study
Clinicians the company named as principal investigators in its Open Payments reports.
Sites paid to run it
Sources: CMS Open Payments research payments (program year 2025) and ClinicalTrials.gov, U.S. National Library of Medicine.