Insulin Lispro Protamin/Lispro
Brand names: Humalog Mix 50-50 Kwikpen, Humalog Mix 75-25 Kwikpen, Humalog Mix 75-25, Insulin Lispro Protamine Mix
Part of: Insulin
At a glance
- Medicare prescriptions, 2024
- 120,346
- Medicare drug cost
- $35.3M
- Average cost per prescription
- $294
- Clinicians who prescribed it
- 5,006
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
HUMALOG Mix50/50 is indicated to improve glycemic control in adults with diabetes mellitus.
From the FDA-approved prescribing information (label dated July 2026). Full labels on DailyMed (opens in a new tab)
Who prescribes it
- Endocrinology & Diabetes 34.7%
- Internal Medicine 21.9%
- Family Medicine 17.3%
- Nurse Practitioners 14.6%
- Physician Assistants 4.7%
- General Practice 4.0%
- Geriatric Medicine 1.1%
- Nephrology (Kidney) 0.3%
- Cardiology 0.3%
- Hospitalist 0.2%
- Pharmacists 0.1%
- Infectious Disease 0.1%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions fell 37% from 2019 to 2024.
Biggest change by state since 2019
- Virginia −22%
- Kentucky −22%
- Connecticut −25%
- Puerto Rico −27%
- Wisconsin −30%
- South Carolina (smallest change) −54%
- Illinois (smallest change) −51%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
Industry payments about this drug
No industry payments to clinicians named this drug in 2025.
Recalls and shortages
Not on the FDA drug shortage list.
No FDA-reported recalls since 2020.
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.