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Insulin

Drug group

At a glance

Medicare prescriptions, 2024
15,132,515
Medicare drug cost
$4.94B
Average cost per prescription
$327
Clinicians who prescribed it
153,351

Where it is prescribed

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What these drugs are

Insulin replaces or adds to the body’s own insulin to control blood sugar in type 1 and type 2 diabetes. Types differ in how fast and how long they work.

Who prescribes it

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Share of Medicare prescriptions written by each specialty.

Drugs in this group

DrugPrescriptionsMedicare cost
Insulin Glargine,hum.Rec.Anlog (Basaglar Kwikpen U-100, Basaglar Tempo Pen U-100, Insulin Glargine) 7,699,612 $1.86B
Insulin Lispro (Admelog Solostar, Humalog, Humalog Junior Kwikpen) 2,081,959 $523.4M
Insulin Degludec (Tresiba, Tresiba Flextouch U-100, Tresiba Flextouch U-200) 1,586,287 $1.29B
Insulin Aspart (Novolog, Novolog Flexpen, Novolog Penfill) 1,422,506 $306.1M
Insulin Glargine-Yfgn (Semglee (Yfgn) Pen, Semglee (Yfgn)) 334,421 $42.9M
Insulin Nph Human Isophane (Humulin N Kwikpen, Novolin N Flexpen, Humulin N) 328,865 $48.8M
Insulin Nph Hum/Reg Insulin Hm (Humulin 70-30, Humulin 70/30 Kwikpen, Novolin 70-30) 317,148 $49.6M
Insulin Detemir (Levemir, Levemir Flexpen, Levemir Flextouch) 287,281 $56.8M
Insulin Regular, Human (Humulin R U-500, Humulin R U-500 Kwikpen, Novolin R) 286,015 $212.7M
Insulin Aspart (Niacinamide) (Fiasp, Fiasp Penfill, Fiasp Flextouch) 263,494 $199.9M
Insulin Pump Cart,auto,bt,g6/7 (Omnipod 5 Dexg7g6 Pods (Gen 5)) 178,561 —
Insulin Aspart Prot/Insuln Asp (Insulin Aspart Prot Mix 70-30, Novolog Mix 70-30, Novolog Mix 70-30 Flexpen) 145,339 $37.0M
Insulin Lispro Protamin/Lispro (Humalog Mix 50-50 Kwikpen, Humalog Mix 75-25 Kwikpen, Humalog Mix 75-25) 120,346 $35.3M
Insulin Lispro-Aabc (Lyumjev, Lyumjev Kwikpen U-200, Lyumjev Kwikpen U-100) 48,369 —
Insulin Pump Cart,cont Inf,bt (Omnipod Dash Pods (Gen 4)) 29,240 —
Insulin Glargine-Aglr (Rezvoglar Kwikpen) 3,373 —
Insulin Pmp Cart,aut,g6/7,cntr (Omnipod 5 Dexg7g6 Intro(Gen 5)) 3,240 —
Insulin Glulisine (Apidra, Apidra Solostar) 1,293 —
Insulin Pump Cart,cont Inf,rf (Omnipod Classic Pods (Gen 3)) 135 —

Drugs filled in fewer than 1,000 counties have no page of their own; their national totals are shown here.

Industry payments about this drug

Drug makers reported $500,549 in payments to clinicians that named this group of drugs in 2025 (meals, speaking, consulting and similar).

  • Mannkind Corporation $444,642
  • Sanofi-aventis U.S. LLC $23,889
  • Sanofi Pasteur Inc. $14,214
  • Sanofi US Services Inc. $9,779
  • Novo Nordisk Inc $7,942
  • Lilly USA, LLC $83

See all companies →

Source: CMS Open Payments, general payments (not research), program year 2025. A payment is not evidence of wrongdoing. Payments by doctor

Recalls and shortages

Not on the FDA drug shortage list.

5 recalls since 2020

  • Mar 2024 · Eli Lilly & Company · Class II
    CGMP Deviations
  • Apr 2023 · Sanofi-Aventis U.S. LLC · Class II
    Lack of Assurance of Sterility: Malformed crimped collar seal
  • Apr 2022 · Cardinal Health Inc. · Class I
    TEMPERATURE ABUSE: Products were exposed to temperatures outside of the products labeled storage conditions due to inclement weather.
  • Mar 2021 · Novo Nordisk Inc · Class I
    Temperature Abuse: product samples were stored at temperatures below 32* F which is not in accordance with storage requirements that could cause a lack of efficacy and damage to the cartridge and pen-injectors.
  • Mar 2021 · Novo Nordisk Inc · Class I
    Temperature Abuse: product samples were stored at temperatures below 32* F which is not in accordance with storage requirements that could cause a lack of efficacy and damage to the cartridge and pen-injectors.

See all recalls →

Recalls usually affect specific lots from one maker, not every version of a drug. Class I is the most serious; most drug recalls are Class II. FDA recalls (opens in a new tab)

Industry-funded trials

Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.